PubMed

Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.

Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML.

Diabetes. 2004 Dec;53 Suppl 3:S225-32. Review.PMID: 15561916 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.

Tsuboi T, da Silva Xavier G, Holz GG, Jouaville LS, Thomas AP, Rutter GA.

Biochem J. 2003 Jan 15;369(Pt 2):287-99.PMID: 12410638 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets.

Kwon G, Marshall CA, Liu H, Pappan KL, Remedi MS, McDaniel ML.

J Biol Chem. 2006 Feb 10;281(6):3261-7. Epub 2005 Dec 12.PMID: 16344552 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets.

Yajima H, Komatsu M, Schermerhorn T, Aizawa T, Kaneko T, Nagai M, Sharp GW, Hashizume K.

Diabetes. 1999 May;48(5):1006-12.PMID: 10331404 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose triggers protein kinase A-dependent insulin secretion in mouse pancreatic islets through activation of the K+ATP channel-dependent pathway.

Thams P, Anwar MR, Capito K.

Eur J Endocrinol. 2005 Apr;152(4):671-7.PMID: 15817925 [PubMed - indexed for MEDLINE]Related articlesFree article

Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.

Komatsu M, Sato Y, Yamada S, Yamauchi K, Hashizume K, Aizawa T.

Diabetes. 2002 Feb;51 Suppl 1:S29-32.PMID: 11815454 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells.

Xu G, Kwon G, Cruz WS, Marshall CA, McDaniel ML.

Diabetes. 2001 Feb;50(2):353-60.PMID: 11272147 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A.

Endocrinology. 2005 Mar;146(3):1328-37. Epub 2004 Dec 2.PMID: 15576463 [PubMed - indexed for MEDLINE]Related articlesFree article

[Ca2+]i-reducing action of cAMP in rat pancreatic beta-cells: involvement of thapsigargin-sensitive stores.

Yaekura K, Yada T.

Am J Physiol. 1998 Feb;274(2 Pt 1):C513-21.PMID: 9486142 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP.

Circ Res. 2004 Dec 10;95(12):1183-90. Epub 2004 Nov 11.PMID: 15539636 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37).

Holz GG, Leech CA, Heller RS, Castonguay M, Habener JF.

J Biol Chem. 1999 May 14;274(20):14147-56.PMID: 10318832 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms.

Sjöholm A.

Diabetes. 1997 Jul;46(7):1141-7.PMID: 9200648 [PubMed - indexed for MEDLINE]Related articles

Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.

Flamez D, Gilon P, Moens K, Van Breusegem A, Delmeire D, Scrocchi LA, Henquin JC, Drucker DJ, Schuit F.

Diabetes. 1999 Oct;48(10):1979-86.PMID: 10512362 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets.

Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML.

Diabetes. 2009 Mar;58(3):663-72. Epub 2008 Dec 10.PMID: 19073772 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase.

Kimball SR, Siegfried BA, Jefferson LS.

J Biol Chem. 2004 Dec 24;279(52):54103-9. Epub 2004 Oct 19.PMID: 15494402 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells.

Kwon G, Pappan KL, Marshall CA, Schaffer JE, McDaniel ML.

J Biol Chem. 2004 Mar 5;279(10):8938-45. Epub 2003 Dec 19.PMID: 14688288 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP-signaling pathway acts in selective synergism with glucose or tolbutamide to increase cytosolic Ca2+ in rat pancreatic beta-cells.

Yaekura K, Kakei M, Yada T.

Diabetes. 1996 Mar;45(3):295-301.PMID: 8593933 [PubMed - indexed for MEDLINE]Related articles

Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells.

Miura Y, Matsui H.

Toxicol Appl Pharmacol. 2006 Nov 1;216(3):363-72. Epub 2006 Jun 6.PMID: 16837018 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic beta-cells independently of protein kinase A.

Bode HP, Moormann B, Dabew R, Göke B.

Endocrinology. 1999 Sep;140(9):3919-27.PMID: 10465260 [PubMed - indexed for MEDLINE]Related articlesFree article

Signal transduction of PACAP and GLP-1 in pancreatic beta cells.

Leech CA, Holz GG, Habener JF.

Ann N Y Acad Sci. 1996 Dec 26;805:81-92; discussion 92-3. Review.PMID: 8993395 [PubMed - indexed for MEDLINE]Related articles