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    Results: 1 to 20 of 588

    1.

    Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.

    Baggio LL, Kim JG, Drucker DJ.

    Diabetes. 2004 Dec;53 Suppl 3:S205-14.PMID: 15561912 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.

    Baggio LL, Huang Q, Brown TJ, Drucker DJ.

    Gastroenterology. 2004 Aug;127(2):546-58.PMID: 15300587 [PubMed - indexed for MEDLINE]Related articles

    3.

    A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.

    Baggio LL, Huang Q, Brown TJ, Drucker DJ.

    Diabetes. 2004 Sep;53(9):2492-500.PMID: 15331566 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.

    Scrocchi LA, Hill ME, Saleh J, Perkins B, Drucker DJ.

    Diabetes. 2000 Sep;49(9):1552-60.PMID: 10969840 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Sustained expression of exendin-4 does not perturb glucose homeostasis, beta-cell mass, or food intake in metallothionein-preproexendin transgenic mice.

    Baggio L, Adatia F, Bock T, Brubaker PL, Drucker DJ.

    J Biol Chem. 2000 Nov 3;275(44):34471-7.PMID: 10952981 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

    Li Y, Cao X, Li LX, Brubaker PL, Edlund H, Drucker DJ.

    Diabetes. 2005 Feb;54(2):482-91.PMID: 15677506 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis.

    Baggio LL, Huang Q, Cao X, Drucker DJ.

    Gastroenterology. 2008 Apr;134(4):1137-47. Epub 2008 Jan 11.PMID: 18313669 [PubMed - indexed for MEDLINE]Related articles

    8.

    Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.

    Baggio L, Kieffer TJ, Drucker DJ.

    Endocrinology. 2000 Oct;141(10):3703-9.PMID: 11014225 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.

    Widmann C, Dolci W, Thorens B.

    Mol Endocrinol. 1996 Jan;10(1):62-75.PMID: 8838146 [PubMed - indexed for MEDLINE]Related articles

    10.

    Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells.

    Salapatek AM, MacDonald PE, Gaisano HY, Wheeler MB.

    Mol Endocrinol. 1999 Aug;13(8):1305-17.PMID: 10446905 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice.

    Maida A, Lovshin JA, Baggio LL, Drucker DJ.

    Endocrinology. 2008 Nov;149(11):5670-8. Epub 2008 Jul 31.PMID: 18669601 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.

    Flamez D, Gilon P, Moens K, Van Breusegem A, Delmeire D, Scrocchi LA, Henquin JC, Drucker DJ, Schuit F.

    Diabetes. 1999 Oct;48(10):1979-86.PMID: 10512362 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo.

    Kim JG, Baggio LL, Bridon DP, Castaigne JP, Robitaille MF, Jetté L, Benquet C, Drucker DJ.

    Diabetes. 2003 Mar;52(3):751-9.PMID: 12606517 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.

    Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ.

    J Biol Chem. 2003 Jan 3;278(1):471-8. Epub 2002 Oct 29.PMID: 12409292 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.

    Hansotia T, Drucker DJ.

    Regul Pept. 2005 Jun 15;128(2):125-34. Review.PMID: 15780432 [PubMed - indexed for MEDLINE]Related articles

    16.

    Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

    Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

    Diabetes. 2004 May;53(5):1326-35.PMID: 15111503 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.

    Scrocchi LA, Marshall BA, Cook SM, Brubaker PL, Drucker DJ.

    Diabetes. 1998 Apr;47(4):632-9.PMID: 9568697 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

    Green BD, Gault VA, Flatt PR, Harriott P, Greer B, O'Harte FP.

    Arch Biochem Biophys. 2004 Aug 15;428(2):136-43.PMID: 15246869 [PubMed - indexed for MEDLINE]Related articles

    19.

    Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues.

    Green BD, Gault VA, Mooney MH, Irwin N, Harriott P, Greer B, Bailey CJ, O'Harte FP, Flatt PR.

    Biol Chem. 2004 Feb;385(2):169-77.PMID: 15101559 [PubMed - indexed for MEDLINE]Related articles

    20.

    Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

    Pederson RA, Satkunarajah M, McIntosh CH, Scrocchi LA, Flamez D, Schuit F, Drucker DJ, Wheeler MB.

    Diabetes. 1998 Jul;47(7):1046-52.PMID: 9648827 [PubMed - indexed for MEDLINE]Related articlesFree article

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