PubMed

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.

Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tîrgoviste C, Savage DA, Dunger DB, Widmer B, Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC, Gough SC, Todd JA.

Diabetes. 2004 Nov;53(11):3020-3.PMID: 15504986 [PubMed - indexed for MEDLINE]Related articlesFree article

Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations.

Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, Tanaka S, Kanazawa Y, Lee I, Eguchi K.

Am J Med Genet A. 2006 Mar 15;140(6):586-93. Erratum in: Am J Med Genet A. 2007 Aug 1;143(15):18212-3. Uga, Mho [corrected to Uga, Miho]. PMID: 16470599 [PubMed - indexed for MEDLINE]Related articles

Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.

Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J.

Diabetologia. 2006 Jun;49(6):1198-208. Epub 2006 Apr 14.PMID: 16614815 [PubMed - indexed for MEDLINE]Related articles

Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.

Zheng W, She JX.

Diabetes. 2005 Mar;54(3):906-8.PMID: 15734872 [PubMed - indexed for MEDLINE]Related articlesFree article

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.

Smyth DJ, Cooper JD, Howson JM, Walker NM, Plagnol V, Stevens H, Clayton DG, Todd JA.

Diabetes. 2008 Jun;57(6):1730-7. Epub 2008 Feb 27.PMID: 18305142 [PubMed - indexed for MEDLINE]Related articlesFree article

Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset.

Skórka A, Bednarczuk T, Bar-Andziak E, Nauman J, Ploski R.

Clin Endocrinol (Oxf). 2005 Jun;62(6):679-82.PMID: 15943829 [PubMed - indexed for MEDLINE]Related articles

PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.

Chelala C, Duchatelet S, Joffret ML, Bergholdt R, Dubois-Laforgue D, Ghandil P, Pociot F, Caillat-Zucman S, Timsit J, Julier C.

Diabetes. 2007 Feb;56(2):522-6.PMID: 17259401 [PubMed - indexed for MEDLINE]Related articlesFree article

A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.

Howson JM, Dunger DB, Nutland S, Stevens H, Wicker LS, Todd JA.

Diabetologia. 2007 Apr;50(4):741-6. Epub 2007 Feb 14.PMID: 17334650 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of PTPN22 in type 1 diabetes and other autoimmune diseases.

Bottini N, Vang T, Cucca F, Mustelin T.

Semin Immunol. 2006 Aug;18(4):207-13. Epub 2006 May 11. Review.PMID: 16697661 [PubMed - indexed for MEDLINE]Related articles

No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.

Cinek O, Hradsky O, Ahmedov G, Slavcev A, Kolouskova S, Kulich M, Sumnik Z.

Diabetes Res Clin Pract. 2007 May;76(2):297-303. Epub 2006 Sep 26.PMID: 17000021 [PubMed - indexed for MEDLINE]Related articles

Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.

Hinks A, Barton A, John S, Bruce I, Hawkins C, Griffiths CE, Donn R, Thomson W, Silman A, Worthington J.

Arthritis Rheum. 2005 Jun;52(6):1694-9.PMID: 15934099 [PubMed - indexed for MEDLINE]Related articlesFree article

A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.

Onengut-Gumuscu S, Buckner JH, Concannon P.

Diabetes. 2006 Oct;55(10):2883-9.PMID: 17003357 [PubMed - indexed for MEDLINE]Related articlesFree article

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.

Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T.

Nat Genet. 2004 Apr;36(4):337-8. Epub 2004 Mar 7.PMID: 15004560 [PubMed - indexed for MEDLINE]Related articles

Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.

Ladner MB, Bottini N, Valdes AM, Noble JA.

Hum Immunol. 2005 Jan;66(1):60-4.PMID: 15620463 [PubMed - indexed for MEDLINE]Related articles

A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families.

Onengut-Gumuscu S, Ewens KG, Spielman RS, Concannon P.

Genes Immun. 2004 Dec;5(8):678-80.PMID: 15526003 [PubMed - indexed for MEDLINE]Related articles

Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.

Santiago JL, Martínez A, de la Calle H, Fernández-Arquero M, Figueredo MA, de la Concha EG, Urcelay E.

BMC Med Genet. 2007 Aug 13;8:54.PMID: 17697317 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene.

Michou L, Lasbleiz S, Rat AC, Migliorini P, Balsa A, Westhovens R, Barrera P, Alves H, Pierlot C, Glikmans E, Garnier S, Dausset J, Vaz C, Fernandes M, Petit-Teixeira E, Lemaire I, Pascual-Salcedo D, Bombardieri S, Dequeker J, Radstake TR, Van Riel P, van de Putte L, Lopes-Vaz A, Prum B, Bardin T, Dieudé P, Cornélis F; European Consortium on Rheumatoid Arthritis Families.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1649-54. Epub 2007 Jan 19.PMID: 17237219 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.

van Oene M, Wintle RF, Liu X, Yazdanpanah M, Gu X, Newman B, Kwan A, Johnson B, Owen J, Greer W, Mosher D, Maksymowych W, Keystone E, Rubin LA, Amos CI, Siminovitch KA.

Arthritis Rheum. 2005 Jul;52(7):1993-8.PMID: 15986374 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the PTPN22/LYP gene with type 1 diabetes.

Steck AK, Liu SY, McFann K, Barriga KJ, Babu SR, Eisenbarth GS, Rewers MJ, She JX.

Pediatr Diabetes. 2006 Oct;7(5):274-8.PMID: 17054449 [PubMed - indexed for MEDLINE]Related articles

Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.

Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F.

Diabetes. 2008 Jan;57(1):229-34. Epub 2007 Oct 12.PMID: 17934143 [PubMed - indexed for MEDLINE]Related articlesFree article