PubMed

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.

Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D.

Diabetes. 2004 Nov;53(11):2901-9.PMID: 15504971 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

Pennisi P, Gavrilova O, Setser-Portas J, Jou W, Santopietro S, Clemmons D, Yakar S, LeRoith D.

Endocrinology. 2006 Jun;147(6):2619-30. Epub 2006 Mar 2.PMID: 16513827 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes.

Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D.

Diabetologia. 2004 Dec;47(12):2215-25. Epub 2004 Dec 15.PMID: 15662559 [PubMed - indexed for MEDLINE]Related articles

Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.

Hong EG, Jung DY, Ko HJ, Zhang Z, Ma Z, Jun JY, Kim JH, Sumner AD, Vary TC, Gardner TW, Bronson SK, Kim JK.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1687-96. Epub 2007 Oct 2.PMID: 17911348 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

Kim H, Haluzik M, Asghar Z, Yau D, Joseph JW, Fernandez AM, Reitman ML, Yakar S, Stannard B, Heron-Milhavet L, Wheeler MB, LeRoith D.

Diabetes. 2003 Jul;52(7):1770-8.PMID: 12829645 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.

Héron-Milhavet L, Haluzik M, Yakar S, Gavrilova O, Pack S, Jou WC, Ibrahimi A, Kim H, Hunt D, Yau D, Asghar Z, Joseph J, Wheeler MB, Abumrad NA, LeRoith D.

Endocrinology. 2004 Oct;145(10):4667-76. Epub 2004 Jul 1.PMID: 15231693 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus.

Kawashima Y, Chen J, Sun H, Lann D, Hajjar RJ, Yakar S, Leroith D.

Diabetologia. 2009 Jul;52(7):1434-41. Epub 2009 May 13.PMID: 19436992 [PubMed - indexed for MEDLINE]Related articles

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.

Kim JK, Zisman A, Fillmore JJ, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI.

J Clin Invest. 2001 Jul;108(1):153-60.PMID: 11435467 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes.

Toyoshima Y, Gavrilova O, Yakar S, Jou W, Pack S, Asghar Z, Wheeler MB, LeRoith D.

Endocrinology. 2005 Sep;146(9):4024-35. Epub 2005 Jun 9.PMID: 15947005 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.

Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB.

Diabetologia. 2006 Jan;49(1):90-9. Epub 2005 Dec 15. Erratum in: Diabetologia. 2006 Mar;49(3):614. PMID: 16362284 [PubMed - indexed for MEDLINE]Related articles

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.

Kim H, Pennisi PA, Gavrilova O, Pack S, Jou W, Setser-Portas J, East-Palmer J, Tang Y, Manganiello VC, Leroith D.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1227-36.PMID: 16682489 [PubMed - indexed for MEDLINE]Related articlesFree article

MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness.

Kim CH, Pennisi P, Zhao H, Yakar S, Kaufman JB, Iganaki K, Shiloach J, Scherer PE, Quon MJ, LeRoith D.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E298-305. Epub 2006 Feb 28.PMID: 16507604 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia.

Moller DE, Chang PY, Yaspelkis BB 3rd, Flier JS, Wallberg-Henriksson H, Ivy JL.

Endocrinology. 1996 Jun;137(6):2397-405.PMID: 8641192 [PubMed - indexed for MEDLINE]Related articles

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.

Carvalho E, Kotani K, Peroni OD, Kahn BB.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E551-61. Epub 2005 May 31.PMID: 15928024 [PubMed - indexed for MEDLINE]Related articlesFree article

Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle.

Capozza F, Combs TP, Cohen AW, Cho YR, Park SY, Schubert W, Williams TM, Brasaemle DL, Jelicks LA, Scherer PE, Kim JK, Lisanti MP.

Am J Physiol Cell Physiol. 2005 Jun;288(6):C1317-31. Epub 2005 Feb 2.PMID: 15689413 [PubMed - indexed for MEDLINE]Related articlesFree article

Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats.

Serradas P, Blondel O, Bailbe D, Portha B.

Diabetes. 1993 Apr;42(4):564-70.PMID: 8454107 [PubMed - indexed for MEDLINE]Related articles

Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains.

Alberts P, Nilsson C, Selen G, Engblom LO, Edling NH, Norling S, Klingström G, Larsson C, Forsgren M, Ashkzari M, Nilsson CE, Fiedler M, Bergqvist E, Ohman B, Björkstrand E, Abrahmsen LB.

Endocrinology. 2003 Nov;144(11):4755-62. Epub 2003 Jul 31.PMID: 12960099 [PubMed - indexed for MEDLINE]Related articlesFree article

Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog.

Kim SP, Ellmerer M, Van Citters GW, Bergman RN.

Diabetes. 2003 Oct;52(10):2453-60.PMID: 14514627 [PubMed - indexed for MEDLINE]Related articlesFree article

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.

Lewis GF, Carpentier A, Adeli K, Giacca A.

Endocr Rev. 2002 Apr;23(2):201-29.PMID: 11943743 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy.

Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB, Cline G, Shulman GI, Sul HS.

Diabetes. 2008 Dec;57(12):3258-66. Epub 2008 Oct 3.PMID: 18835937 [PubMed - indexed for MEDLINE]Related articlesFree article