PubMed

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals.

Handschin C, Blättler S, Roth A, Looser R, Oscarson M, Kaufmann MR, Podvinec M, Gnerre C, Meyer UA.

Nucl Recept. 2004 Oct 12;2(1):7.PMID: 15479477 [PubMed - as supplied by publisher]Related articlesFree article

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).

Handschin C, Podvinec M, Meyer UA.

Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10769-74.PMID: 11005856 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.

Reschly EJ, Krasowski MD.

Curr Drug Metab. 2006 May;7(4):349-65. Review.PMID: 16724925 [PubMed - indexed for MEDLINE]Related articlesFree article

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.

Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, Moore JT.

Mol Endocrinol. 2002 May;16(5):977-86.PMID: 11981033 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor.

Handschin C, Podvinec M, Looser R, Amherd R, Meyer UA.

Mol Pharmacol. 2001 Oct;60(4):681-9.PMID: 11562429 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Xu C, Li CY, Kong AN.

Arch Pharm Res. 2005 Mar;28(3):249-68. Review.PMID: 15832810 [PubMed - indexed for MEDLINE]Related articles

Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.

Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA.

Mol Pharmacol. 2008 Apr;73(4):1282-9. Epub 2008 Jan 10.PMID: 18187584 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

Krasowski MD, Yasuda K, Hagey LR, Schuetz EG.

Nucl Recept. 2005 Sep 30;3:2.PMID: 16197547 [PubMed]Related articlesFree article

The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.

Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B.

Mol Endocrinol. 2007 Sep;21(9):2099-111. Epub 2007 Jun 26.PMID: 17595319 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR.

J Clin Invest. 2008 Sep;118(9):3228-39.PMID: 18677425 [PubMed - indexed for MEDLINE]Related articlesFree article

CAR and PXR: xenosensors of endocrine disrupters?

Kretschmer XC, Baldwin WS.

Chem Biol Interact. 2005 Aug 15;155(3):111-28. Review.PMID: 16054614 [PubMed - indexed for MEDLINE]Related articles

The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.

Liu MJ, Takahashi Y, Wada T, He J, Gao J, Tian Y, Li S, Xie W.

Mol Pharmacol. 2009 Sep;76(3):604-11. Epub 2009 Jun 19.PMID: 19542321 [PubMed - indexed for MEDLINE]Related articles

Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.

Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA.

Mol Pharmacol. 2005 Sep;68(3):747-57. Epub 2005 Jun 2.PMID: 15933212 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit.

Baader M, Gnerre C, Stegeman JJ, Meyer UA.

J Biol Chem. 2002 May 3;277(18):15647-53. Epub 2002 Feb 26.PMID: 11867618 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450.

Handschin C, Podvinec M, Amherd R, Looser R, Ourlin JC, Meyer UA.

J Biol Chem. 2002 Aug 16;277(33):29561-7. Epub 2002 Jun 3.PMID: 12045201 [PubMed - indexed for MEDLINE]Related articlesFree article

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.

Drug Metab Dispos. 2007 Jul;35(7):1032-41. Epub 2007 Mar 28.PMID: 17392393 [PubMed - indexed for MEDLINE]Related articlesFree article

Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies.

Poso A, Honkakoski P.

Mini Rev Med Chem. 2006 Aug;6(8):937-47. Review.PMID: 16918499 [PubMed - indexed for MEDLINE]Related articles

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects.

di Masi A, Marinis ED, Ascenzi P, Marino M.

Mol Aspects Med. 2009 Oct;30(5):297-343. Epub 2009 May 7. Review.PMID: 19427329 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1.

Sugatani J, Nishitani S, Yamakawa K, Yoshinari K, Sueyoshi T, Negishi M, Miwa M.

Mol Pharmacol. 2005 Mar;67(3):845-55. Epub 2004 Nov 22.PMID: 15557560 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of drug metabolism: the role of nuclear receptors.

Handschin C, Meyer UA.

Pharmacol Rev. 2003 Dec;55(4):649-73. Review.PMID: 14657421 [PubMed - indexed for MEDLINE]Related articlesFree article