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    Results: 1 to 20 of 143

    1.

    Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion.

    Moore PC, Ugas MA, Hagman DK, Parazzoli SD, Poitout V.

    Diabetes. 2004 Oct;53(10):2610-6.PMID: 15448091 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.

    Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V.

    J Biol Chem. 2003 Aug 8;278(32):30015-21. Epub 2003 May 27.PMID: 12771145 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

    Zhou YP, Grill VE.

    J Clin Invest. 1994 Feb;93(2):870-6.PMID: 8113418 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.

    Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY.

    Diabetes. 2001 Jan;50(1):69-76.PMID: 11147797 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase.

    Kelpe CL, Johnson LM, Poitout V.

    Endocrinology. 2002 Sep;143(9):3326-32.PMID: 12193544 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

    Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V.

    Diabetes. 2001 Feb;50(2):315-21.PMID: 11272142 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

    Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P.

    Clin Sci (Lond). 2004 Feb;106(2):191-9.PMID: 14561212 [PubMed - indexed for MEDLINE]Related articles

    8.

    Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox.

    Yoshikawa H, Tajiri Y, Sako Y, Hashimoto T, Umeda F, Nawata H.

    Metabolism. 2001 May;50(5):613-8.PMID: 11319727 [PubMed - indexed for MEDLINE]Related articles

    9.

    Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet.

    Arantes VC, Reis MA, Latorraca MQ, Ferreira F, Stoppiglia LF, Carneiro EM, Boschero AC.

    Br J Nutr. 2006 Dec;96(6):1006-12.PMID: 17181874 [PubMed - indexed for MEDLINE]Related articles

    10.

    Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

    Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

    Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro.

    Carlsson C, Borg LA, Welsh N.

    Endocrinology. 1999 Aug;140(8):3422-8.PMID: 10433196 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

    Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

    Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

    Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ.

    J Clin Invest. 1998 Mar 1;101(5):1094-101.PMID: 9486980 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.

    Bollheimer LC, Kemptner DM, Kagerbauer SM, Kestler TM, Wrede CE, Buettner R.

    Eur J Endocrinol. 2003 Apr;148(4):481-6.PMID: 12656670 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.

    Ritz-Laser B, Meda P, Constant I, Klages N, Charollais A, Morales A, Magnan C, Ktorza A, Philippe J.

    Endocrinology. 1999 Sep;140(9):4005-14.PMID: 10465270 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets.

    Kominato R, Fujimoto S, Mukai E, Nakamura Y, Nabe K, Shimodahira M, Nishi Y, Funakoshi S, Seino Y, Inagaki N.

    Diabetologia. 2008 Jul;51(7):1226-35. Epub 2008 May 1.PMID: 18449527 [PubMed - indexed for MEDLINE]Related articles

    17.

    Fatty acid inhibition of glucose-stimulated insulin secretion is enhanced in pancreatic islets from insulin-resistant rats.

    Chen NG, Reaven GM.

    Metabolism. 1999 Oct;48(10):1314-7.PMID: 10535396 [PubMed - indexed for MEDLINE]Related articles

    18.

    Acute inhibition of proinsulin biosynthesis at the translational level by palmitic acid.

    Katahira H, Nagamatsu S, Ozawa S, Nakamichi Y, Yamaguchi S, Furukawa H, Takizawa M, Yoshimoto K, Itagaki E, Ishida H.

    Biochem Biophys Res Commun. 2001 Mar 30;282(2):507-10.PMID: 11401488 [PubMed - indexed for MEDLINE]Related articles

    19.

    D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways.

    Takahashi H, Tran PO, LeRoy E, Harmon JS, Tanaka Y, Robertson RP.

    J Biol Chem. 2004 Sep 3;279(36):37316-23. Epub 2004 Jun 22.PMID: 15213233 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

    Leloup C, Tourrel-Cuzin C, Magnan C, Karaca M, Castel J, Carneiro L, Colombani AL, Ktorza A, Casteilla L, Pénicaud L.

    Diabetes. 2009 Mar;58(3):673-81. Epub 2008 Dec 10.PMID: 19073765 [PubMed - indexed for MEDLINE]Related articlesFree article

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