PubMed

A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.

Olcott AP, Tocco G, Tian J, Zekzer D, Fukuto J, Ignarro L, Kaufman DL.

Diabetes. 2004 Oct;53(10):2574-80.PMID: 15448086 [PubMed - indexed for MEDLINE]Related articlesFree article

An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice.

Suarez-Pinzon WL, Mabley JG, Strynadka K, Power RF, Szabó C, Rabinovitch A.

J Autoimmun. 2001 Jun;16(4):449-55.PMID: 11437493 [PubMed - indexed for MEDLINE]Related articles

Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice.

Makhlouf L, Grey ST, Dong V, Csizmadia E, Arvelo MB, Auchincloss H Jr, Ferran C, Sayegh MH.

Transplantation. 2004 Apr 15;77(7):990-7.PMID: 15087759 [PubMed - indexed for MEDLINE]Related articles

Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies.

Doctrow SR, Huffman K, Marcus CB, Tocco G, Malfroy E, Adinolfi CA, Kruk H, Baker K, Lazarowych N, Mascarenhas J, Malfroy B.

J Med Chem. 2002 Sep 26;45(20):4549-58.PMID: 12238934 [PubMed - indexed for MEDLINE]Related articles

Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells.

Suarez-Pinzon WL, Szabó C, Rabinovitch A.

Diabetes. 1997 May;46(5):907-11.PMID: 9133563 [PubMed - indexed for MEDLINE]Related articles

Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics.

Sharpe MA, Ollosson R, Stewart VC, Clark JB.

Biochem J. 2002 Aug 15;366(Pt 1):97-107.PMID: 11994046 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in suppressor of cytokine signaling-1 (SOCS-1) expressing islet allograft destruction in normal BALB/c and spontaneously-diabetic NOD recipient mice.

Solomon M, Flodström-Tullberg M, Sarvetnick N.

Transplantation. 2005 May 15;79(9):1104-9.PMID: 15880051 [PubMed - indexed for MEDLINE]Related articles

Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species.

Tocco G, Illigens BM, Malfroy B, Benichou G.

Cell Immunol. 2006 Jun;241(2):59-65. Epub 2006 Sep 12.PMID: 16970930 [PubMed - indexed for MEDLINE]Related articles

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.

Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, Yuan X, Trikudanathan S, Smith RN, Freeman G, Sayegh MH.

Clin Immunol. 2008 Feb;126(2):140-7. Epub 2007 Sep 24.PMID: 17889619 [PubMed - indexed for MEDLINE]Related articles

EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.

van Empel VP, Bertrand AT, van Oort RJ, van der Nagel R, Engelen M, van Rijen HV, Doevendans PA, Crijns HJ, Ackerman SL, Sluiter W, De Windt LJ.

J Am Coll Cardiol. 2006 Aug 15;48(4):824-32. Epub 2006 Jul 25.PMID: 16904556 [PubMed - indexed for MEDLINE]Related articles

Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse.

Nanji SA, Hancock WW, Luo B, Schur CD, Pawlick RL, Zhu LF, Anderson CC, Shapiro AM.

Diabetes. 2006 Jan;55(1):27-33.PMID: 16380473 [PubMed - indexed for MEDLINE]Related articlesFree article

The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro.

Mabley JG, Southan GJ, Salzman AL, Szabó C.

Pancreas. 2004 Mar;28(2):E39-44.PMID: 15028959 [PubMed - indexed for MEDLINE]Related articles

Prevention of type 1 diabetes: from the view point of beta cell damage.

Kawasaki E, Abiru N, Eguchi K.

Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S27-32. Review.PMID: 15563975 [PubMed - indexed for MEDLINE]Related articles

Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice.

Wong CP, Li L, Frelinger JA, Tisch R.

J Immunol. 2006 Feb 1;176(3):1637-44.PMID: 16424193 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of salen and manganese-salen complex (EUK-8) on the regulation of cellular cadmium uptake and toxicity.

Yang PM, Chiu SJ, Lin LY.

Toxicol Sci. 2005 May;85(1):551-9. Epub 2005 Feb 2.PMID: 15689422 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species.

Li X, Chen H, Epstein PN.

J Biol Chem. 2004 Jan 2;279(1):765-71. Epub 2003 Oct 23.PMID: 14576162 [PubMed - indexed for MEDLINE]Related articlesFree article

EUK-8 a synthetic catalytic scavenger of reactive oxygen species protects isolated iron-overloaded rat heart from functional and structural damage induced by ischemia/reperfusion.

Pucheu S, Boucher F, Sulpice T, Tresallet N, Bonhomme Y, Malfroy B, de Leiris J.

Cardiovasc Drugs Ther. 1996 Jul;10(3):331-9.PMID: 8877076 [PubMed - indexed for MEDLINE]Related articles

beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger.

Bruce AJ, Malfroy B, Baudry M.

Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6.PMID: 8637869 [PubMed - indexed for MEDLINE]Related articlesFree article

MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.

Kupfer TM, Crawford ML, Pham K, Gill RG.

J Immunol. 2005 Aug 15;175(4):2309-16.PMID: 16081800 [PubMed - indexed for MEDLINE]Related articlesFree article

Indefinite islet protection from autoimmune destruction in nonobese diabetic mice by agarose microencapsulation without immunosuppression.

Kobayashi T, Aomatsu Y, Iwata H, Kin T, Kanehiro H, Hisanaga M, Ko S, Nagao M, Nakajima Y.

Transplantation. 2003 Mar 15;75(5):619-25.PMID: 12640299 [PubMed - indexed for MEDLINE]Related articles