PubMed

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses.

Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS.

Diabetes. 2004 Oct;53(10):2542-51.PMID: 15448082 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS.

Diabetes. 2005 Nov;54(11):3169-74.PMID: 16249441 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.

Chan O, Lawson M, Zhu W, Beverly JL, Sherwin RS.

Diabetes. 2007 Apr;56(4):1120-6. Epub 2007 Jan 24.PMID: 17251273 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.

Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS.

Diabetes. 2006 Apr;55(4):1080-7.PMID: 16567532 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.

McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS.

Diabetes. 2004 Aug;53(8):1953-8.PMID: 15277372 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.

Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS.

Diabetes. 1999 Mar;48(3):584-7.PMID: 10078560 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

Fan X, Ding Y, Brown S, Zhou L, Shaw M, Vella MC, Cheng H, McNay EC, Sherwin RS, McCrimmon RJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1702-8. Epub 2009 Apr 8.PMID: 19357294 [PubMed - indexed for MEDLINE]Related articles

Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI.

J Clin Invest. 1997 Jan 15;99(2):361-5.PMID: 9006005 [PubMed - indexed for MEDLINE]Related articlesFree article

Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.

Diabetes. 2008 Dec;57(12):3327-34. Epub 2008 Sep 5.PMID: 18776135 [PubMed - indexed for MEDLINE]Related articlesFree article

Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release.

Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI.

Diabetes. 1995 Feb;44(2):180-4.PMID: 7859938 [PubMed - indexed for MEDLINE]Related articles

Evidence for hypothalamic K+(ATP) channels in the modulation of glucose homeostasis.

Zhang Y, Zhou J, Corll C, Porter JR, Martin RJ, Roane DS.

Eur J Pharmacol. 2004 May 10;492(1):71-9.PMID: 15145709 [PubMed - indexed for MEDLINE]Related articles

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI.

J Clin Invest. 1994 Apr;93(4):1677-82.PMID: 8163668 [PubMed - indexed for MEDLINE]Related articlesFree article

Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation.

Borg MA, Tamborlane WV, Shulman GI, Sherwin RS.

Diabetes. 2003 Mar;52(3):663-6.PMID: 12606506 [PubMed - indexed for MEDLINE]Related articlesFree article

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia.

McCrimmon RJ, Shaw M, Fan X, Cheng H, Ding Y, Vella MC, Zhou L, McNay EC, Sherwin RS.

Diabetes. 2008 Feb;57(2):444-50. Epub 2007 Oct 31.PMID: 17977955 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.

Muñoz A, Hu M, Hussain K, Bryan J, Aguilar-Bryan L, Rajan AS.

Endocrinology. 2005 Dec;146(12):5514-21. Epub 2005 Aug 25.PMID: 16123162 [PubMed - indexed for MEDLINE]Related articlesFree article

Fructose amplifies counterregulatory responses to hypoglycemia in humans.

Gabriely I, Hawkins M, Vilcu C, Rossetti L, Shamoon H.

Diabetes. 2002 Apr;51(4):893-900.PMID: 11916904 [PubMed - indexed for MEDLINE]Related articlesFree article

Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation.

McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS.

J Clin Invest. 2006 Jun;116(6):1723-30.PMID: 16741581 [PubMed - indexed for MEDLINE]Related articlesFree article

Caudal hindbrain lactate infusion alters glucokinase, SUR1, and neuronal substrate fuel transporter gene expression in the dorsal vagal complex, lateral hypothalamic area, and ventromedial nucleus hypothalamus of hypoglycemic male rats.

Vavaiya KV, Briski KP.

Brain Res. 2007 Oct 24;1176:62-70. Epub 2007 Aug 10.PMID: 17889836 [PubMed - indexed for MEDLINE]Related articles

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S.

Nat Neurosci. 2001 May;4(5):507-12.PMID: 11319559 [PubMed - indexed for MEDLINE]Related articles

Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.

Chan O, Cheng H, Herzog R, Czyzyk D, Zhu W, Wang A, McCrimmon RJ, Seashore MR, Sherwin RS.

Diabetes. 2008 May;57(5):1363-70. Epub 2008 Mar 28.PMID: 18375441 [PubMed - indexed for MEDLINE]Related articlesFree article