PubMed

Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy.

Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, Lorenzi M.

Diabetes. 2004 Sep;53(9):2404-11.PMID: 15331552 [PubMed - indexed for MEDLINE]Related articlesFree article

Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes.

Amano S, Yamagishi S, Kato N, Inagaki Y, Okamoto T, Makino M, Taniko K, Hirooka H, Jomori T, Takeuchi M.

Biochem Biophys Res Commun. 2002 Nov 29;299(2):183-8.PMID: 12437967 [PubMed - indexed for MEDLINE]Related articles

The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient.

Lorenzi M.

Exp Diabetes Res. 2007;2007:61038. Review.PMID: 18224243 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.

Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, Lorenzi M.

Diabetes. 2003 Feb;52(2):506-11.PMID: 12540628 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.

Berrone E, Beltramo E, Solimine C, Ape AU, Porta M.

J Biol Chem. 2006 Apr 7;281(14):9307-13. Epub 2006 Feb 1.PMID: 16452468 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats.

Kato N, Yashima S, Suzuki T, Nakayama Y, Jomori T.

J Diabetes Complications. 2003 Nov-Dec;17(6):374-9.PMID: 14583184 [PubMed - indexed for MEDLINE]Related articles

Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB).

Kador PF, Randazzo J, Blessing K, Makita J, Zhang P, Yu K, Hosoya K, Terasaki T.

J Ocul Pharmacol Ther. 2009 Aug;25(4):299-308.PMID: 19450153 [PubMed - indexed for MEDLINE]Related articles

The role of polyol pathway in glucose-induced apoptosis of cultured retinal pericytes.

Miwa K, Nakamura J, Hamada Y, Naruse K, Nakashima E, Kato K, Kasuya Y, Yasuda Y, Kamiya H, Hotta N.

Diabetes Res Clin Pract. 2003 Apr;60(1):1-9.PMID: 12639759 [PubMed - indexed for MEDLINE]Related articles

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, Stevens MJ.

Diabetes. 2003 Mar;52(3):864-71.PMID: 12606532 [PubMed - indexed for MEDLINE]Related articlesFree article

Sorbinil prevention of diabetic-like retinopathy in the galactose-fed rat model.

Robison WG Jr, Laver NM, Jacot JL, Glover JP.

Invest Ophthalmol Vis Sci. 1995 Nov;36(12):2368-80.PMID: 7591626 [PubMed - indexed for MEDLINE]Related articlesFree article

A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.

Sun W, Oates PJ, Coutcher JB, Gerhardinger C, Lorenzi M.

Diabetes. 2006 Oct;55(10):2757-62.PMID: 17003340 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors.

Kador PF, Akagi Y, Takahashi Y, Ikebe H, Wyman M, Kinoshita JH.

Arch Ophthalmol. 1990 Sep;108(9):1301-9.PMID: 2119169 [PubMed - indexed for MEDLINE]Related articles

Polyol formation and NADPH-dependent reductases in dog retinal capillary pericytes and endothelial cells.

Sato S, Secchi EF, Lizak MJ, Fukase S, Ohta N, Murata M, Tsai JY, Kador PF.

Invest Ophthalmol Vis Sci. 1999 Mar;40(3):697-704.PMID: 10067973 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes.

Naruse K, Nakamura J, Hamada Y, Nakayama M, Chaya S, Komori T, Kato K, Kasuya Y, Miwa K, Hotta N.

Exp Eye Res. 2000 Sep;71(3):309-15.PMID: 10973739 [PubMed - indexed for MEDLINE]Related articles

Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of retinal tissues in a streptozotocin-induced diabetic rat model.

Akita M, Mizuno K, Matsubara A, Nakano K, Kurono M.

Acta Med Okayama. 1993 Oct;47(5):299-304.PMID: 8273453 [PubMed - indexed for MEDLINE]Related articles

Galactose-induced retinal microangiopathy in rats.

Kern TS, Engerman RL.

Invest Ophthalmol Vis Sci. 1995 Feb;36(2):490-6.PMID: 7843917 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors.

Kador PF, Akagi Y, Terubayashi H, Wyman M, Kinoshita JH.

Arch Ophthalmol. 1988 Aug;106(8):1099-102.PMID: 3401138 [PubMed - indexed for MEDLINE]Related articles

Increased retinal endothelial cell monolayer permeability induced by the diabetic milieu: role of advanced non-enzymatic glycation and polyol pathway activation.

Leto G, Pricci F, Amadio L, Iacobini C, Cordone S, Diaz-Horta O, Romeo G, Barsotti P, Rotella CM, di Mario U, Pugliese G.

Diabetes Metab Res Rev. 2001 Nov-Dec;17(6):448-58.PMID: 11757081 [PubMed - indexed for MEDLINE]Related articles

An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia.

Frank RN, Amin R, Kennedy A, Hohman TC.

Arch Ophthalmol. 1997 Aug;115(8):1036-47.PMID: 9258227 [PubMed - indexed for MEDLINE]Related articles

Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells.

Takamura Y, Tomomatsu T, Kubo E, Tsuzuki S, Akagi Y.

Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3216-23. Epub 2008 Mar 24.PMID: 18362110 [PubMed - indexed for MEDLINE]Related articlesFree article