PubMed

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.

Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED.

Diabetes. 2004 Sep;53(9):2366-74.PMID: 15331547 [PubMed - indexed for MEDLINE]Related articlesFree article

Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.

Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED.

Endocrinology. 2008 Aug;149(8):4043-50. Epub 2008 May 1.PMID: 18450963 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.

Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED.

Circulation. 2005 Oct 25;112(17):2686-95.PMID: 16246967 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED.

Endocrinology. 2005 Dec;146(12):5341-9. Epub 2005 Sep 1.PMID: 16141388 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice.

Hafstad AD, Khalid AM, How OJ, Larsen TS, Aasum E.

Am J Physiol Endocrinol Metab. 2007 May;292(5):E1288-94. Epub 2007 Jan 9.PMID: 17213470 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat.

Lopaschuk GD, Russell JC.

J Appl Physiol. 1991 Oct;71(4):1302-8.PMID: 1757353 [PubMed - indexed for MEDLINE]Related articles

Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart.

Broderick TL, Quinney HA, Lopaschuk GD.

J Biol Chem. 1992 Feb 25;267(6):3758-63.PMID: 1740427 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts.

Saddik M, Lopaschuk GD.

J Biol Chem. 1991 May 5;266(13):8162-70.PMID: 1902472 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acids attenuate insulin regulation of 5'-AMP-activated protein kinase and insulin cardioprotection after ischemia.

Folmes CD, Clanachan AS, Lopaschuk GD.

Circ Res. 2006 Jul 7;99(1):61-8. Epub 2006 Jun 1.PMID: 16741157 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium regulation of glycolysis, glucose oxidation, and fatty acid oxidation in the aerobic and ischemic heart.

Schönekess BO, Brindley PG, Lopaschuk GD.

Can J Physiol Pharmacol. 1995 Nov;73(11):1632-40.PMID: 8789418 [PubMed - indexed for MEDLINE]Related articles

Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding.

Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED.

Cardiovasc Res. 2009 May 1;82(2):351-60. Epub 2009 Jan 15.PMID: 19147655 [PubMed - indexed for MEDLINE]Related articles

Glucose and fatty acid metabolism in the isolated working mouse heart.

Belke DD, Larsen TS, Lopaschuk GD, Severson DL.

Am J Physiol. 1999 Oct;277(4 Pt 2):R1210-7.PMID: 10516264 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of cardiac protein kinase B is regulated by palmitate.

Soltys CL, Buchholz L, Gandhi M, Clanachan AS, Walsh K, Dyck JR.

Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H1056-64.PMID: 12181135 [PubMed - indexed for MEDLINE]Related articlesFree article

Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts.

McCormack JG, Barr RL, Wolff AA, Lopaschuk GD.

Circulation. 1996 Jan 1;93(1):135-42.PMID: 8616920 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency.

Broderick TL, Christos SC, Wolf BA, DiDomenico D, Shug AL, Paulson DJ.

Metabolism. 1995 Apr;44(4):499-505.PMID: 7723673 [PubMed - indexed for MEDLINE]Related articles

Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.

Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R.

Circulation. 2009 Jun 2;119(21):2818-28. Epub 2009 May 18.PMID: 19451348 [PubMed - indexed for MEDLINE]Related articles

Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats.

Wang P, Lloyd SG, Zeng H, Bonen A, Chatham JC.

Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2102-10. Epub 2004 Dec 22.PMID: 15615844 [PubMed - indexed for MEDLINE]Related articlesFree article

Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin.

Hafstad AD, Solevåg GH, Severson DL, Larsen TS, Aasum E.

Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1763-9. Epub 2005 Dec 3.PMID: 16327015 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice.

Belke DD, Larsen TS, Gibbs EM, Severson DL.

Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1104-13.PMID: 11052966 [PubMed - indexed for MEDLINE]Related articlesFree article

The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

Kantor PF, Lucien A, Kozak R, Lopaschuk GD.

Circ Res. 2000 Mar 17;86(5):580-8.PMID: 10720420 [PubMed - indexed for MEDLINE]Related articlesFree article