PubMed

Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.

Arden C, Harbottle A, Baltrusch S, Tiedge M, Agius L.

Diabetes. 2004 Sep;53(9):2346-52.PMID: 15331544 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.

Stubbs M, Aiston S, Agius L.

Diabetes. 2000 Dec;49(12):2048-55.PMID: 11118006 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L.

Biochem J. 2008 Apr 1;411(1):41-51.PMID: 18039179 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets.

Ishihara H, Asano T, Tsukuda K, Katagiri H, Inukai K, Anai M, Kikuchi M, Yazaki Y, Miyazaki JI, Oka Y.

Diabetologia. 1993 Nov;36(11):1139-45.PMID: 8270128 [PubMed - indexed for MEDLINE]Related articles

A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin.

Rizzo MA, Magnuson MA, Drain PF, Piston DW.

J Biol Chem. 2002 Sep 13;277(37):34168-75. Epub 2002 Jul 5.PMID: 12101177 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of beta cell glucokinase by S-nitrosylation and association with nitric oxide synthase.

Rizzo MA, Piston DW.

J Cell Biol. 2003 Apr 28;161(2):243-8. Epub 2003 Apr 21.PMID: 12707306 [PubMed - indexed for MEDLINE]Related articlesFree article

Monitoring of glucose-regulated single insulin secretory granule movement by selective photoactivation.

Baltrusch S, Lenzen S.

Diabetologia. 2008 Jun;51(6):989-96. Epub 2008 Apr 4.PMID: 18389213 [PubMed - indexed for MEDLINE]Related articles

Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells.

Baltrusch S, Lenzen S.

Diabetes. 2007 May;56(5):1305-15. Epub 2007 Feb 7.PMID: 17287461 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glucose-induced insulin secretion through inactivation of glucokinase by glyceraldehyde.

Murata T, Miwa I, Toyoda Y, Okuda J.

Diabetes. 1993 Jul;42(7):1003-9.PMID: 8513967 [PubMed - indexed for MEDLINE]Related articles

Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells.

Baltrusch S, Langer S, Massa L, Tiedge M, Lenzen S.

Endocrinology. 2006 Dec;147(12):5768-76. Epub 2006 Sep 15.PMID: 16980436 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.

Ma L, Bindokas VP, Kuznetsov A, Rhodes C, Hays L, Edwardson JM, Ueda K, Steiner DF, Philipson LH.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9266-71. Epub 2004 Jun 14.PMID: 15197259 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis.

Mendez CF, Leibiger IB, Leibiger B, Høy M, Gromada J, Berggren PO, Bertorello AM.

J Biol Chem. 2003 Nov 7;278(45):44753-7. Epub 2003 Aug 25.PMID: 12941947 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of the glucokinase-glucose sensor in pancreatic islets of insulinoma-bearing rats following tumor removal.

Bedoya FJ, Appel MC, Goberna R, Matschinsky FM.

Adv Exp Med Biol. 1986;211:447-57. No abstract available. PMID: 3037862 [PubMed - indexed for MEDLINE]Related articles

Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles.

Möhlig M, Wolter S, Mayer P, Lang J, Osterhoff M, Horn PA, Schatz H, Pfeiffer A.

Endocrinology. 1997 Jun;138(6):2577-84.PMID: 9165051 [PubMed - indexed for MEDLINE]Related articlesFree article

Alteration of anomeric preference of glucose-induced insulin secretion by glyceraldehyde.

Murata T, Miwa I, Okuda J.

Life Sci. 1993;53(17):1373-82.PMID: 8412503 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator.

Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ.

Diabetes. 2007 Jun;56(6):1694-702. Epub 2007 Mar 14.PMID: 17360975 [PubMed - indexed for MEDLINE]Related articlesFree article

Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats.

Payne VA, Arden C, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R618-25. Epub 2007 Jun 6.PMID: 17553851 [PubMed - indexed for MEDLINE]Related articles

Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells.

Varadi A, Tsuboi T, Rutter GA.

Mol Biol Cell. 2005 Jun;16(6):2670-80. Epub 2005 Mar 23.PMID: 15788565 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular distribution of hexokinase isoenzymes in pancreatic islet cells exposed to digitonin after incubation at a low or high concentration of D-glucose.

Vanhoutte C, Sener A, Malaisse WJ.

Mol Cell Biochem. 1997 Oct;175(1-2):131-6.PMID: 9350043 [PubMed - indexed for MEDLINE]Related articles

Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic beta-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopy.

Ohara-Imaizumi M, Nakamichi Y, Tanaka T, Katsuta H, Ishida H, Nagamatsu S.

Biochem J. 2002 Apr 1;363(Pt 1):73-80.PMID: 11903049 [PubMed - indexed for MEDLINE]Related articlesFree article