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    Results: 1 to 20 of 366

    1.

    Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

    Gurgul E, Lortz S, Tiedge M, Jörns A, Lenzen S.

    Diabetes. 2004 Sep;53(9):2271-80.PMID: 15331536 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

    Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S.

    Diabetes. 2000 Jul;49(7):1123-30.PMID: 10909968 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines.

    Lortz S, Gurgul-Convey E, Lenzen S, Tiedge M.

    Diabetologia. 2005 Aug;48(8):1541-8. Epub 2005 Jun 29.PMID: 15986238 [PubMed - indexed for MEDLINE]Related articles

    4.

    Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.

    Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M.

    Diabetes. 2003 Jan;52(1):93-101.PMID: 12502498 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Sequential inactivation of reactive oxygen species by combined overexpression of SOD isoforms and catalase in insulin-producing cells.

    Lortz S, Tiedge M.

    Free Radic Biol Med. 2003 Mar 15;34(6):683-8.PMID: 12633745 [PubMed - indexed for MEDLINE]Related articles

    6.

    Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species.

    Tiedge M, Lortz S, Munday R, Lenzen S.

    Diabetes. 1998 Oct;47(10):1578-85.PMID: 9753295 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

    Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.

    Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.PMID: 11593036 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity.

    Chen H, Li X, Epstein PN.

    Diabetes. 2005 May;54(5):1437-46.PMID: 15855331 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells.

    Tiedge M, Lortz S, Munday R, Lenzen S.

    Diabetologia. 1999 Jul;42(7):849-55.PMID: 10440128 [PubMed - indexed for MEDLINE]Related articles

    10.

    Fetal pig beta cells are resistant to the toxic effects of human cytokines.

    Bai L, Tuch BE, Hering B, Simpson AM.

    Transplantation. 2002 Mar 15;73(5):714-22.PMID: 11907416 [PubMed - indexed for MEDLINE]Related articles

    11.

    STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.

    Jensen J, Galsgaard ED, Karlsen AE, Lee YC, Nielsen JH.

    J Endocrinol. 2005 Oct;187(1):25-36.PMID: 16214938 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines.

    Chen G, Hohmeier HE, Newgard CB.

    J Biol Chem. 2001 Jan 5;276(1):766-72.PMID: 11024034 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    The role of oxygen-derived free radicals and nitric oxide in cytokine-induced antiproliferation of pancreatic cancer cells.

    Thomas WJ, Thomas DL, Knezetic JA, Adrian TE.

    Pancreas. 2002 Mar;24(2):161-8.PMID: 11854621 [PubMed - indexed for MEDLINE]Related articles

    14.

    Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation.

    Kim EK, Kwon KB, Song MY, Han MJ, Lee JH, Lee YR, Lee JH, Ryu DG, Park BH, Park JW.

    Pancreas. 2007 Nov;35(4):e1-9.PMID: 18090225 [PubMed - indexed for MEDLINE]Related articles

    15.

    Overexpression of catalase provides partial protection to transgenic mouse beta cells.

    Xu B, Moritz JT, Epstein PN.

    Free Radic Biol Med. 1999 Oct;27(7-8):830-7.PMID: 10515587 [PubMed - indexed for MEDLINE]Related articles

    16.

    Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production.

    Hohmeier HE, Thigpen A, Tran VV, Davis R, Newgard CB.

    J Clin Invest. 1998 May 1;101(9):1811-20.PMID: 9576743 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Deltapsi(m)) in pancreatic RINm5F cells: prevention by Bcl-2.

    Barbu A, Welsh N, Saldeen J.

    Mol Cell Endocrinol. 2002 Apr 25;190(1-2):75-82.PMID: 11997180 [PubMed - indexed for MEDLINE]Related articles

    18.

    Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.

    Tiedge M, Lortz S, Drinkgern J, Lenzen S.

    Diabetes. 1997 Nov;46(11):1733-42.PMID: 9356019 [PubMed - indexed for MEDLINE]Related articles

    19.

    Catalase protects cardiomyocytes via its inhibition of nitric oxide synthesis.

    Chae HJ, Ha KC, Kim DS, Cheung GS, Kwak YG, Kim HM, Kim YM, Pae HO, Chung HT, Chae SW, Kim HR.

    Nitric Oxide. 2006 May;14(3):189-99. Epub 2006 Jan 5.PMID: 16403660 [PubMed - indexed for MEDLINE]Related articles

    20.

    Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy.

    Tran VV, Chen G, Newgard CB, Hohmeier HE.

    Diabetes. 2003 Jun;52(6):1423-32.PMID: 12765953 [PubMed - indexed for MEDLINE]Related articlesFree article

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