PubMed

Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody.

Herold KC, Bluestone JA, Montag AG, Parihar A, Wiegner A, Gress RE, Hirsch R.

Diabetes. 1992 Mar;41(3):385-91.PMID: 1532369 [PubMed - indexed for MEDLINE]Related articles

Differential T cell hyporesponsiveness induced by in vivo administration of intact or F(ab')2 fragments of anti-CD3 monoclonal antibody. F(ab')2 fragments induce a selective T helper dysfunction.

Hirsch R, Archibald J, Gress RE.

J Immunol. 1991 Oct 1;147(7):2088-93.PMID: 1833451 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb.

Hirsch R, Bluestone JA, DeNenno L, Gress RE.

Transplantation. 1990 Jun;49(6):1117-23.PMID: 2141740 [PubMed - indexed for MEDLINE]Related articles

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

Ledbetter JA, June CH, Martin PJ, Spooner CE, Hansen JA, Meier KE.

J Immunol. 1986 Jun 1;136(11):3945-52.PMID: 3084650 [PubMed - indexed for MEDLINE]Related articles

OKT3 F(ab')2 fragments--retention of the immunosuppressive properties of whole antibody with marked reduction in T cell activation and lymphokine release.

Woodle ES, Thistlethwaite JR, Ghobrial IA, Jolliffe LK, Stuart FP, Bluestone JA.

Transplantation. 1991 Aug;52(2):354-60.PMID: 1908148 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 immunotoxin prevents low-dose STZ/interferon-induced autoimmune diabetes in mouse.

Vallera DA, Carroll SF, Brief S, Blazar BR.

Diabetes. 1992 Apr;41(4):457-64.PMID: 1376702 [PubMed - indexed for MEDLINE]Related articles

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

Hirsch R, Gress RE, Pluznik DH, Eckhaus M, Bluestone JA.

J Immunol. 1989 Feb 1;142(3):737-43.PMID: 2521507 [PubMed - indexed for MEDLINE]Related articles

In vivo administration of anti-murine CD3 monoclonal antibody induces selective, long-term anergy in CD8+ T cells.

Woodle ES, Hussein S, Bluestone JA.

Transplantation. 1996 Mar 15;61(5):798-803.PMID: 8607186 [PubMed - indexed for MEDLINE]Related articles

In vivo administration of anti-CD3 monoclonal antibodies or immunotoxins in murine recipients of allogeneic T cell-depleted marrow for the promotion of engraftment.

Blazar BR, Hirsch R, Gress RE, Carroll SF, Vallera DA.

J Immunol. 1991 Sep 1;147(5):1492-503.PMID: 1831826 [PubMed - indexed for MEDLINE]Related articles

Therapy for ongoing graft-versus-host disease induced across the major or minor histocompatibility barrier in mice with anti-CD3F(ab')2-ricin toxin A chain immunotoxin.

Vallera DA, Taylor PA, Panoskaltsis-Mortari A, Blazar BR.

Blood. 1995 Dec 1;86(11):4367-75.PMID: 7492798 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-CD3 x anti-tumor F(ab')2 bifunctional antibody activates and retargets tumor-infiltrating lymphocytes.

Chapoval AI, Nelson H, Thibault C.

J Immunol. 1995 Aug 1;155(3):1296-303.PMID: 7636196 [PubMed - indexed for MEDLINE]Related articles

Neonatal injection of CD3 antibody into nonobese diabetic mice reduces the incidence of insulitis and diabetes.

Hayward AR, Shreiber M.

J Immunol. 1989 Sep 1;143(5):1555-9.PMID: 2527266 [PubMed - indexed for MEDLINE]Related articles

Trispecific F(ab')3 derivatives that use cooperative signaling via the TCR/CD3 complex and CD2 to activate and redirect resting cytotoxic T cells.

Tutt A, Stevenson GT, Glennie MJ.

J Immunol. 1991 Jul 1;147(1):60-9.PMID: 1675655 [PubMed - indexed for MEDLINE]Related articles

Idarubicin-145-2C11-F(ab')2 promotes peripheral tolerance and reduces chronic vascular disease in mouse cardiac allografts.

Han WR, Murray-Segal LJ, Gershenzon A, Zhang JG, Hodder AN, Pietersz GA, Mottram PL.

Transpl Immunol. 1999 Dec;7(4):207-13.PMID: 10638833 [PubMed - indexed for MEDLINE]Related articles

A novel model for antigen-dependent activation of normal human T cells. Transmembrane signaling by crosslinkage of the CD3/T cell receptor-alpha/beta complex with the cluster determinant 2 antigen.

Suthanthiran M.

J Exp Med. 1990 Jun 1;171(6):1965-79.PMID: 1972176 [PubMed - indexed for MEDLINE]Related articlesFree article

Imaging of human leukemic T-cell xenografts in nude mice by radiolabeled monoclonal antibodies and F(ab')2 fragments.

Vacca A, Buchegger F, Carrel S, Mach JP.

Cancer. 1988 Jan 1;61(1):58-67.PMID: 3257154 [PubMed - indexed for MEDLINE]Related articles

Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice.

Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y.

Am J Pathol. 2008 Apr;172(4):972-9. Epub 2008 Mar 18.PMID: 18349126 [PubMed - indexed for MEDLINE]Related articlesFree article

Advantages of F(ab')2 fragments of anti-CD3 monoclonal antibody as compared to whole antibody as immunosuppressive agents in mice.

Hirsch R, Bluestone JA, Bare CV, Gress RE.

Transplant Proc. 1991 Feb;23(1 Pt 1):270-1. No abstract available. PMID: 1824981 [PubMed - indexed for MEDLINE]Related articles

Mitogenic activity of anti-CD28 MoAb CLB-CD28/1 on peripheral blood mononuclear cells and its cooperation with other anti-T cells MoAb in the activation of purified T lymphocytes.

De Felice M, Giarrusso PC, Lamberti A, Turco MC, Valerio G, van Lier RA, Yang SY, Ferrone S, Venuta S.

Tissue Antigens. 1990 Jul;36(1):12-8.PMID: 1701062 [PubMed - indexed for MEDLINE]Related articles

Induction of suppressor cells to T- and B-cell proliferative responses and immunoglobulin production by monoclonal antibodies recognizing the CD3 T-cell differentiation antigen.

Kunicka JE, Platsoucas CD.

Cell Immunol. 1988 Oct 1;116(1):195-215.PMID: 2901914 [PubMed - indexed for MEDLINE]Related articles