PubMed

Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels.

Gu HF, Efendic S, Nordman S, Ostenson CG, Brismar K, Brookes AJ, Prince JA.

Diabetes. 2004 Aug;53(8):2137-42.PMID: 15277398 [PubMed - indexed for MEDLINE]Related articlesFree article

Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

Nordman S, Ostenson CG, Efendic S, Gu HF.

Exp Clin Endocrinol Diabetes. 2009 Apr;117(4):186-90. Epub 2008 Dec 3.PMID: 19053027 [PubMed - indexed for MEDLINE]Related articles

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.

Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, McCarthy MI, Altshuler D, Groop L.

Diabetes. 2006 Jan;55(1):128-35.PMID: 16380485 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study.

Karamohamed S, Demissie S, Volcjak J, Liu C, Heard-Costa N, Liu J, Shoemaker CM, Panhuysen CI, Meigs JB, Wilson P, Atwood LD, Cupples LA, Herbert A; NHLBI Framingham Heart Study.

Diabetes. 2003 Jun;52(6):1562-7.PMID: 12765971 [PubMed - indexed for MEDLINE]Related articlesFree article

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI.

Diabetes. 2003 May;52(5):1300-5.PMID: 12716770 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population.

Kwak SH, Cho YM, Moon MK, Kim JH, Park BL, Cheong HS, Shin HD, Jang HC, Kim SY, Lee HK, Park KS.

Diabetes Res Clin Pract. 2008 Feb;79(2):284-90. Epub 2007 Oct 25.PMID: 17913278 [PubMed - indexed for MEDLINE]Related articles

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.

Blomqvist ME, Chalmers K, Andreasen N, Bogdanovic N, Wilcock GK, Cairns NJ, Feuk L, Brookes AJ, Love S, Blennow K, Kehoe PG, Prince JA.

Neurobiol Aging. 2005 Jun;26(6):795-802.PMID: 15718037 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.

Prince JA, Feuk L, Gu HF, Johansson B, Gatz M, Blennow K, Brookes AJ.

Hum Mutat. 2003 Nov;22(5):363-71.PMID: 14517947 [PubMed - indexed for MEDLINE]Related articles

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

Abraham R, Myers A, Wavrant-DeVrieze F, Hamshere ML, Thomas HV, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon JM, Petersen RC, Tangalos E, Norton J, Morris JC, Bullock R, Liolitsa D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ, Jones L.

Hum Genet. 2001 Dec;109(6):646-52. Epub 2001 Nov 1.PMID: 11810277 [PubMed - indexed for MEDLINE]Related articles

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.

Bian L, Yang JD, Guo TW, Sun Y, Duan SW, Chen WY, Pan YX, Feng GY, He L.

Neurology. 2004 Jul 27;63(2):241-5.PMID: 15277615 [PubMed - indexed for MEDLINE]Related articles

Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk.

Marlowe L, Peila R, Benke KS, Hardy J, White LR, Launer LJ, Myers A.

Neurodegener Dis. 2006;3(6):320-6.PMID: 17192720 [PubMed - indexed for MEDLINE]Related articles

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.

Ertekin-Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen RC, Graff-Radford N, Younkin SG.

Hum Mutat. 2004 Apr;23(4):334-42.PMID: 15024728 [PubMed - indexed for MEDLINE]Related articles

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.

Blomqvist ME, Silburn PA, Buchanan DD, Andreasen N, Blennow K, Pedersen NL, Brookes AJ, Mellick GD, Prince JA.

Neurogenetics. 2004 Jun;5(2):115-9. Epub 2004 Apr 16.PMID: 15088150 [PubMed - indexed for MEDLINE]Related articles

Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease.

Feuk L, McCarthy S, Andersson B, Prince JA, Brookes AJ.

Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):69-71.PMID: 15858821 [PubMed - indexed for MEDLINE]Related articles

Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis.

An P, Freedman BI, Hanis CL, Chen YD, Weder AB, Schork NJ, Boerwinkle E, Province MA, Hsiung CA, Wu X, Quertermous T, Rao DC.

Diabetes. 2005 Mar;54(3):909-14.PMID: 15734873 [PubMed - indexed for MEDLINE]Related articlesFree article

Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation.

Lautier C, El Mkadem SA, Renard E, Brun JF, Gris JC, Bringer J, Grigorescu F.

Hum Genet. 2003 Jul;113(1):34-43. Epub 2003 Apr 10.PMID: 12687350 [PubMed - indexed for MEDLINE]Related articles

Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.

Kovacs P, Geyer M, Berndt J, Klöting N, Graham TE, Böttcher Y, Enigk B, Tönjes A, Schleinitz D, Schön MR, Kahn BB, Blüher M, Stumvoll M.

Diabetes. 2007 Dec;56(12):3095-100. Epub 2007 Aug 29.PMID: 17728376 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait loci on chromosome 8q24 for pancreatic beta-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Network (HyperGEN) study.

An P, Freedman BI, Rich SS, Mandel SA, Arnett DK, Myers RH, Chen YD, Hunt SC, Rao DC.

Diabetes. 2006 Feb;55(2):551-8.PMID: 16443794 [PubMed - indexed for MEDLINE]Related articlesFree article

A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans.

Duggirala R, Blangero J, Almasy L, Arya R, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP.

Am J Hum Genet. 2001 May;68(5):1149-64. Epub 2001 Mar 29.PMID: 11283790 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits.

Rathcke CN, Holmkvist J, Jørgensen T, Borch-Johnsen K, Hansen T, Pedersen OB, Vestergaard H.

PLoS One. 2009;4(5):e5469. Epub 2009 May 7.PMID: 19421404 [PubMed - indexed for MEDLINE]Related articlesFree article