PubMed

Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.

Price SA, Agthong S, Middlemas AB, Tomlinson DR.

Diabetes. 2004 Jul;53(7):1851-6.PMID: 15220210 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy.

Purves T, Middlemas A, Agthong S, Jude EB, Boulton AJ, Fernyhough P, Tomlinson DR.

FASEB J. 2001 Nov;15(13):2508-14.PMID: 11689477 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of c-Jun N-terminal kinase (JNK) in sensory neurones of diabetic rats, with possible effects on nerve conduction and neuropathic pain: prevention with an aldose reductase inhibitor.

Middlemas AB, Agthong S, Tomlinson DR.

Diabetologia. 2006 Mar;49(3):580-7. Epub 2006 Feb 3.PMID: 16456679 [PubMed - indexed for MEDLINE]Related articles

Inhibition of p38 MAP kinase corrects biochemical and neurological deficits in experimental diabetic neuropathy.

Agthong S, Tomlinson DR.

Ann N Y Acad Sci. 2002 Nov;973:359-62.PMID: 12485893 [PubMed - indexed for MEDLINE]Related articles

Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy.

Mizuno K, Kato N, Makino M, Suzuki T, Shindo M.

J Diabetes Complications. 1999 May-Jun;13(3):141-50.PMID: 10509874 [PubMed - indexed for MEDLINE]Related articles

Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.

Uehara K, Yamagishi S, Otsuki S, Chin S, Yagihashi S.

Diabetes. 2004 Dec;53(12):3239-47.PMID: 15561956 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.

Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ, Yorek MA.

Diabetes. 2005 Jan;54(1):234-42.PMID: 15616034 [PubMed - indexed for MEDLINE]Related articlesFree article

p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury.

Xu JT, Xin WJ, Wei XH, Wu CY, Ge YX, Liu YL, Zang Y, Zhang T, Li YY, Liu XG.

Exp Neurol. 2007 Mar;204(1):355-65. Epub 2006 Dec 21.PMID: 17258708 [PubMed - indexed for MEDLINE]Related articles

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

Jin SX, Zhuang ZY, Woolf CJ, Ji RR.

J Neurosci. 2003 May 15;23(10):4017-22.PMID: 12764087 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.

Kato N, Mizuno K, Makino M, Suzuki T, Yagihashi S.

Diabetes Res Clin Pract. 2000 Oct;50(2):77-85.PMID: 10960717 [PubMed - indexed for MEDLINE]Related articles

Effect of the aldose reductase inhibitor fidarestat on experimental diabetic neuropathy in the rat.

Kuzumoto Y, Kusunoki S, Kato N, Kihara M, Low PA.

Diabetologia. 2006 Dec;49(12):3085-93. Epub 2006 Oct 25.PMID: 17063327 [PubMed - indexed for MEDLINE]Related articles

Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3.

Middlemas A, Delcroix JD, Sayers NM, Tomlinson DR, Fernyhough P.

Brain. 2003 Jul;126(Pt 7):1671-82. Epub 2003 Apr 22.PMID: 12805110 [PubMed - indexed for MEDLINE]Related articlesFree article

Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.

Price SA, Gardiner NJ, Duran-Jimenez B, Zeef LA, Obrosova IG, Tomlinson DR.

Brain Res. 2006 Oct 20;1116(1):206-14. Epub 2006 Aug 30.PMID: 16938273 [PubMed - indexed for MEDLINE]Related articles

Thirteen-month inhibition of aldose reductase by zenarestat prevents morphological abnormalities in the dorsal root ganglia of streptozotocin-induced diabetic rats.

Shimoshige Y, Minoura K, Matsuoka N, Takakura S, Mutoh S, Kamijo M.

Brain Res. 2009 Jan 9;1247:182-7. Epub 2008 Nov 1.PMID: 18992730 [PubMed - indexed for MEDLINE]Related articles

Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy.

Chattopadhyay M, Mata M, Fink DJ.

J Neurosci. 2008 Jun 25;28(26):6652-8.PMID: 18579738 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, Fukuoka T, Tokunaga A, Noguchi K.

J Neurosci. 2004 Nov 10;24(45):10211-22.PMID: 15537893 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.

Yue DK, Hanwell MA, Satchell PM, Turtle JR.

Diabetes. 1982 Sep;31(9):789-94.PMID: 6819173 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons.

Schäfers M, Svensson CI, Sommer C, Sorkin LS.

J Neurosci. 2003 Apr 1;23(7):2517-21.PMID: 12684435 [PubMed - indexed for MEDLINE]Related articlesFree article

Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs.

Engerman RL, Kern TS, Larson ME.

Diabetologia. 1994 Feb;37(2):141-4.PMID: 8163047 [PubMed - indexed for MEDLINE]Related articles

An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.

Obrosova IG, Van Huysen C, Fathallah L, Cao XC, Greene DA, Stevens MJ.

FASEB J. 2002 Jan;16(1):123-5. Epub 2001 Nov 14.PMID: 11709499 [PubMed - indexed for MEDLINE]Related articlesFree article