My NCBI | Sign In
RSS Settings
  • Search:

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

    Results: 1 to 20 of 793

    1.

    Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

    Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

    Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis.

    Fei H, Zhao B, Zhao S, Wang Q.

    Mol Cell Biochem. 2008 Aug;315(1-2):75-84. Epub 2008 May 23.PMID: 18498041 [PubMed - indexed for MEDLINE]Related articles

    3.

    Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

    Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

    J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

    Dabrowski M, Larsen T, Ashcroft FM, Bondo Hansen J, Wahl P.

    Diabetologia. 2003 Oct;46(10):1375-82. Epub 2003 Sep 5.PMID: 12961066 [PubMed - indexed for MEDLINE]Related articles

    5.

    NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

    Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.

    Diabetes. 2003 Oct;52(10):2513-8.PMID: 14514634 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.

    Størling J, Zaitsev SV, Kapelioukh IL, Karlsen AE, Billestrup N, Berggren PO, Mandrup-Poulsen T.

    Endocrinology. 2005 Jul;146(7):3026-36. Epub 2005 Apr 14.PMID: 15831571 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

    Alemzadeh R, Fledelius C, Bodvarsdottir T, Sturis J.

    Metabolism. 2004 Apr;53(4):441-7.PMID: 15045689 [PubMed - indexed for MEDLINE]Related articles

    8.

    The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects.

    Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A, Dyrberg T.

    J Clin Pharmacol. 2005 Jul;45(7):763-72.PMID: 15951466 [PubMed - indexed for MEDLINE]Related articles

    9.

    A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.

    Itabashi N, Okada K, Muto S, Fujita N, Ohta T, Miyazaki Ji, Asano Y, Saito T.

    J Pharmacol Exp Ther. 2001 Jun;297(3):953-60.PMID: 11356916 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential.

    Kullin M, Li Z, Bondo Hansen J, Welsh N, Karlsson FA, Sandler S.

    Diabetologia. 2003 Jan;46(1):80-8. Epub 2003 Jan 11.PMID: 12637986 [PubMed - indexed for MEDLINE]Related articles

    11.

    Glucose triggers protein kinase A-dependent insulin secretion in mouse pancreatic islets through activation of the K+ATP channel-dependent pathway.

    Thams P, Anwar MR, Capito K.

    Eur J Endocrinol. 2005 Apr;152(4):671-7.PMID: 15817925 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.

    Koriyama N, Kakei M, Nakazaki M, Yaekura K, Ichinari K, Gong Q, Morimitsu S, Yada T, Tei C.

    Diabetes. 2000 Nov;49(11):1830-9.PMID: 11078449 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.

    Larsen CM, Wadt KA, Juhl LF, Andersen HU, Karlsen AE, Su MS, Seedorf K, Shapiro L, Dinarello CA, Mandrup-Poulsen T.

    J Biol Chem. 1998 Jun 12;273(24):15294-300.PMID: 9614146 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

    Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.

    Diabetes. 2008 Dec;57(12):3327-34. Epub 2008 Sep 5.PMID: 18776135 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells.

    Moritz W, Leech CA, Ferrer J, Habener JF.

    Endocrinology. 2001 Jan;142(1):129-38.PMID: 11145575 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.

    Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J.

    J Pharmacol Exp Ther. 2007 Aug;322(2):871-8. Epub 2007 May 23.PMID: 17522344 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.

    Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC.

    J Biol Chem. 2004 Jul 30;279(31):32316-24. Epub 2004 Jun 1.PMID: 15175349 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway.

    Westerlund J, Ortsäter H, Palm F, Sundsten T, Bergsten P.

    Eur J Endocrinol. 2001 Jun;144(6):667-75.PMID: 11375802 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

    Hansen JB.

    Curr Med Chem. 2006;13(4):361-76. Review.PMID: 16475928 [PubMed - indexed for MEDLINE]Related articles

    20.

    The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.

    Ng B, Kang Y, Elias CL, He Y, Xie H, Hansen JB, Wahl P, Gaisano HY.

    Diabetes. 2007 Aug;56(8):2124-34. Epub 2007 May 11.PMID: 17496234 [PubMed - indexed for MEDLINE]Related articlesFree article

    Supplemental Content

    Filter your results:

    Find related data

    Recent activity