PubMed

Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.

Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL.

Diabetes. 2004 Jul;53(7):1684-91.PMID: 15220191 [PubMed - indexed for MEDLINE]Related articlesFree article

Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.

Kubosaki A, Nakamura S, Notkins AL.

Diabetes. 2005 Dec;54 Suppl 2:S46-51.PMID: 16306340 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.

Kubosaki A, Nakamura S, Clark A, Morris JF, Notkins AL.

Endocrinology. 2006 Feb;147(2):811-5. Epub 2005 Nov 3.PMID: 16269463 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion.

Saeki K, Zhu M, Kubosaki A, Xie J, Lan MS, Notkins AL.

Diabetes. 2002 Jun;51(6):1842-50.PMID: 12031972 [PubMed - indexed for MEDLINE]Related articlesFree article

The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

Harashima S, Clark A, Christie MR, Notkins AL.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. Epub 2005 Jun 6.PMID: 15939893 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.

Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):885-90. Epub 2006 Jan 17.PMID: 16418280 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS.

Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11.PMID: 8637868 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies.

Kawakami T, Saeki K, Takeyama N, Wu G, Sakudo A, Matsumoto Y, Hayashi T, Onodera T.

Int J Mol Med. 2007 Aug;20(2):177-85.PMID: 17611635 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

J Endocrinol. 2008 Mar;196(3):573-81.PMID: 18310453 [PubMed - indexed for MEDLINE]Related articlesFree article

Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes.

Trembleau S, Penna G, Gregori S, Magistrelli G, Isacchi A, Adorini L.

J Immunol. 2000 Dec 15;165(12):6748-55.PMID: 11120794 [PubMed - indexed for MEDLINE]Related articlesFree article

Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen.

Kolm-Litty V, Berlo S, Bonifacio E, Bearzatto M, Engel AM, Christie M, Ziegler AG, Wild T, Endl J.

J Immunol. 2000 Oct 15;165(8):4676-84.PMID: 11035111 [PubMed - indexed for MEDLINE]Related articlesFree article

IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.

Zahn TR, Macmorris MA, Dong W, Day R, Hutton JC.

J Comp Neurol. 2001 Jan 1;429(1):127-43.PMID: 11086294 [PubMed - indexed for MEDLINE]Related articles

Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse.

Koczwara K, Schenker M, Schmid S, Kredel K, Ziegler AG, Bonifacio E.

Clin Immunol. 2003 Feb;106(2):155-62.PMID: 12672406 [PubMed - indexed for MEDLINE]Related articles

Comparison of IA-2 with IA-2beta and with six other members of the protein tyrosine phosphatase family: recognition of antigenic determinants by IDDM sera.

Notkins AL, Zhang B, Matsumoto Y, Lan MS.

J Autoimmun. 1997 Jun;10(3):245-50.PMID: 9218750 [PubMed - indexed for MEDLINE]Related articles

Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2.

Seissler J, Schott M, Morgenthaler NG, Scherbaum WA.

Clin Exp Immunol. 2000 Nov;122(2):157-63.PMID: 11091269 [PubMed - indexed for MEDLINE]Related articlesFree article

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.

Bonifacio E, Atkinson M, Eisenbarth G, Serreze D, Kay TW, Lee-Chan E, Singh B.

Diabetes. 2001 Nov;50(11):2451-8. Review.PMID: 11679421 [PubMed - indexed for MEDLINE]Related articlesFree article

Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN).

Xie J, Zhang B, Lan MS, Notkins AL.

Genomics. 1998 Dec 1;54(2):338-43.PMID: 9828138 [PubMed - indexed for MEDLINE]Related articles

HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.

Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC.

J Immunol. 2004 Mar 15;172(6):3955-62.PMID: 15004204 [PubMed - indexed for MEDLINE]Related articlesFree article

Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F.

van den Maagdenberg AM, Schepens JT, Schepens MT, Pepers B, Wieringa B, van Kessel AG, Hendriks WJ.

Cytogenet Cell Genet. 1998;82(3-4):153-5.PMID: 9858807 [PubMed - indexed for MEDLINE]Related articles

The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.

Cai T, Krause MW, Odenwald WF, Toyama R, Notkins AL.

Diabetologia. 2001 Jan;44(1):81-8.PMID: 11206415 [PubMed - indexed for MEDLINE]Related articles