PubMed

Diabetes-associated mutations in insulin identify invariant receptor contacts.

Xu B, Hu SQ, Chu YC, Wang S, Wang RY, Nakagawa SH, Katsoyannis PG, Weiss MA.

Diabetes. 2004 Jun;53(6):1599-602.PMID: 15161767 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

Wan ZL, Huang K, Xu B, Hu SQ, Wang S, Chu YC, Katsoyannis PG, Weiss MA.

Biochemistry. 2005 Apr 5;44(13):5000-16.PMID: 15794638 [PubMed - indexed for MEDLINE]Related articles

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

Xu B, Hu SQ, Chu YC, Huang K, Nakagawa SH, Whittaker J, Katsoyannis PG, Weiss MA.

Biochemistry. 2004 Jul 6;43(26):8356-72.PMID: 15222748 [PubMed - indexed for MEDLINE]Related articles

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice.

Huang K, Chan SJ, Hua QX, Chu YC, Wang RY, Klaproth B, Jia W, Whittaker J, De Meyts P, Nakagawa SH, Steiner DF, Katsoyannis PG, Weiss MA.

J Biol Chem. 2007 Nov 30;282(48):35337-49. Epub 2007 Sep 20.PMID: 17884811 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.

Hua QX, Shoelson SE, Inouye K, Weiss MA.

Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):582-6.PMID: 8421693 [PubMed - indexed for MEDLINE]Related articlesFree article

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

Huang K, Xu B, Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang S, Wang RY, Nakagawa SH, Theede AM, Whittaker J, De Meyts P, Katsoyannis PG, Weiss MA.

J Mol Biol. 2004 Aug 6;341(2):529-50.PMID: 15276842 [PubMed - indexed for MEDLINE]Related articles

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

Xu B, Huang K, Chu YC, Hu SQ, Nakagawa S, Wang S, Wang RY, Whittaker J, Katsoyannis PG, Weiss MA.

J Biol Chem. 2009 May 22;284(21):14597-608. Epub 2009 Mar 25.PMID: 19321435 [PubMed - indexed for MEDLINE]Related articles

A structurally abnormal insulin causing human diabetes.

Tager H, Given B, Baldwin D, Mako M, Markese J, Rubenstein A, Olefsky J, Kobayashi M, Kolterman O, Poucher R.

Nature. 1979 Sep 13;281(5727):122-5.PMID: 381941 [PubMed - indexed for MEDLINE]Related articles

Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins.

Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA.

J Biol Chem. 2009 May 22;284(21):14586-96. Epub 2009 Mar 25.PMID: 19321436 [PubMed - indexed for MEDLINE]Related articles

Insulin analogs with B24 or B25 phenylalanine replaced by biphenylalanine.

Du H, Shi J, Cui D, Zhang Y.

Acta Biochim Biophys Sin (Shanghai). 2008 Feb;40(2):133-9.PMID: 18235975 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.

Wan Z, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA.

Biochemistry. 2004 Dec 28;43(51):16119-33.PMID: 15610006 [PubMed - indexed for MEDLINE]Related articles

Mutational analysis of invariant valine B12 in insulin: implications for receptor binding.

Nakagawa SH, Tager HS, Steiner DF.

Biochemistry. 2000 Dec 26;39(51):15826-35.PMID: 11123908 [PubMed - indexed for MEDLINE]Related articles

Lessons learned from molecular biology of insulin-gene mutations.

Steiner DF, Tager HS, Chan SJ, Nanjo K, Sanke T, Rubenstein AH.

Diabetes Care. 1990 Jun;13(6):600-9. Review.PMID: 2192846 [PubMed - indexed for MEDLINE]Related articles

Two mutant forms of human insulin. Structural consequences of the substitution of invariant B24- or B25-phenylalanine by leucine.

Wollmer A, Strassburger W, Glatter U, Dodson GG, McCall M, Gattner HG, Danho W, Brandenburg D, Rittel W.

Hoppe Seylers Z Physiol Chem. 1981 Jun;362(6):581-91.PMID: 7024084 [PubMed - indexed for MEDLINE]Related articles

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.

Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA.

J Mol Biol. 2002 Feb 22;316(3):435-41.PMID: 11866509 [PubMed - indexed for MEDLINE]Related articles

Isosteric replacement of A3 Val of porcine insulin by allo-Thr.

Li M, Cui D, Zhang Y.

IUBMB Life. 2002 Jan;53(1):57-60.PMID: 12018409 [PubMed - indexed for MEDLINE]Related articles

Receptor binding redefined by a structural switch in a mutant human insulin.

Hua QX, Shoelson SE, Kochoyan M, Weiss MA.

Nature. 1991 Nov 21;354(6350):238-41.PMID: 1961250 [PubMed - indexed for MEDLINE]Related articles

Insulin gene mutations as a cause of permanent neonatal diabetes.

Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12.PMID: 17855560 [PubMed - indexed for MEDLINE]Related articlesFree article

The structure and function of insulin: decoding the TR transition.

Weiss MA.

Vitam Horm. 2009;80:33-49.PMID: 19251033 [PubMed - indexed for MEDLINE]Related articles

[Mutations in the insulin receptor gene in patients with genetic forms of insulin resistance]

Kadowaki T, Kasuga M.

Nippon Rinsho. 1991 Feb;49 Suppl:721-30. Japanese. No abstract available. PMID: 2033869 [PubMed - indexed for MEDLINE]Related articles