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    Results: 1 to 20 of 316

    1.

    A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.

    Toye AA, Moir L, Hugill A, Bentley L, Quarterman J, Mijat V, Hough T, Goldsworthy M, Haynes A, Hunter AJ, Browne M, Spurr N, Cox RD.

    Diabetes. 2004 Jun;53(6):1577-83.PMID: 15161764 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.

    Inoue M, Sakuraba Y, Motegi H, Kubota N, Toki H, Matsui J, Toyoda Y, Miwa I, Terauchi Y, Kadowaki T, Shigeyama Y, Kasuga M, Adachi T, Fujimoto N, Matsumoto R, Tsuchihashi K, Kagami T, Inoue A, Kaneda H, Ishijima J, Masuya H, Suzuki T, Wakana S, Gondo Y, Minowa O, Shiroishi T, Noda T.

    Hum Mol Genet. 2004 Jun 1;13(11):1147-57. Epub 2004 Apr 21.PMID: 15102714 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesis.

    Ruan HB, Zhang N, Gao X.

    Genetics. 2005 Feb;169(2):819-31.PMID: 15731517 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.

    Bali D, Svetlanov A, Lee HW, Fusco-DeMane D, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N, et al.

    J Biol Chem. 1995 Sep 15;270(37):21464-7.PMID: 7665557 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.

    Galán M, Vincent O, Roncero I, Azriel S, Boix-Pallares P, Delgado-Alvarez E, Díaz-Cadórniga F, Blázquez E, Navas MA.

    Biochem J. 2006 Jan 1;393(Pt 1):389-96.PMID: 16173921 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu.

    Nam Y, Kim JK, Cha DS, Cho JW, Cho KH, Yoon S, Yoon JB, Oh YS, Suh JG, Han SS, Song CW, Yoon SK.

    Genomics. 2006 Apr;87(4):520-6. Epub 2006 Feb 7.PMID: 16455232 [PubMed - indexed for MEDLINE]Related articles

    7.

    Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity.

    García-Herrero CM, Galán M, Vincent O, Flández B, Gargallo M, Delgado-Alvarez E, Blázquez E, Navas MA.

    Diabetologia. 2007 Feb;50(2):325-33. Epub 2006 Dec 21.PMID: 17186219 [PubMed - indexed for MEDLINE]Related articles

    8.

    Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.

    Estalella I, Garcia-Gimeno MA, Marina A, Castaño L, Sanz P.

    J Hum Genet. 2008;53(5):460-6. Epub 2008 Mar 6.PMID: 18322640 [PubMed - indexed for MEDLINE]Related articles

    9.

    Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.

    Aigner B, Rathkolb B, Herbach N, Hrabé de Angelis M, Wanke R, Wolf E.

    Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E232-40. Epub 2007 Dec 4. Review.PMID: 18056790 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.

    Stoffel M, Froguel P, Takeda J, Zouali H, Vionnet N, Nishi S, Weber IT, Harrison RW, Pilkis SJ, Lesage S, et al.

    Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7698-702. Erratum in: Proc Natl Acad Sci U S A 1992 Nov 1;89(21):10562. PMID: 1502186 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9.

    Longo-Guess C, Gagnon LH, Bergstrom DE, Johnson KR.

    Hear Res. 2007 Dec;234(1-2):21-8. Epub 2007 Sep 29.PMID: 17967520 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1.

    Aponte JL, Sega GA, Hauser LJ, Dhar MS, Withrow CM, Carpenter DA, Rinchik EM, Culiat CT, Johnson DK.

    Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):641-5.PMID: 11209059 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.

    Rinchik EM, Carpenter DA.

    Genetics. 1999 May;152(1):373-83.PMID: 10224267 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse.

    Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Nojima K, Babaya N, Yamada K, Shibata M, Yamato E, Ogihara T.

    Diabetologia. 2000 Jul;43(7):932-8.PMID: 10952468 [PubMed - indexed for MEDLINE]Related articles

    15.

    Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.

    Sakura H, Ashcroft SJ, Terauchi Y, Kadowaki T, Ashcroft FM.

    Diabetologia. 1998 Jun;41(6):654-9.PMID: 9662046 [PubMed - indexed for MEDLINE]Related articles

    16.

    Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency.

    Liu H, Du X, Wang M, Huang Q, Ding L, McDonald HW, Yates JR 3rd, Beutler B, Horwitz J, Gong X.

    J Biol Chem. 2005 Jul 1;280(26):25071-8. Epub 2005 May 4.PMID: 15878859 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    An ENU-induced mutation in the Ankrd11 gene results in an osteopenia-like phenotype in the mouse mutant Yoda.

    Barbaric I, Perry MJ, Dear TN, Rodrigues Da Costa A, Salopek D, Marusic A, Hough T, Wells S, Hunter AJ, Cheeseman M, Brown SD.

    Physiol Genomics. 2008 Feb 19;32(3):311-21. Epub 2007 Nov 6.PMID: 17986521 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor.

    Lee D, Cross SH, Strunk KE, Morgan JE, Bailey CL, Jackson IJ, Threadgill DW.

    Mamm Genome. 2004 Jul;15(7):525-36.PMID: 15366372 [PubMed - indexed for MEDLINE]Related articles

    19.

    Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.

    Michaud EJ, Culiat CT, Klebig ML, Barker PE, Cain KT, Carpenter DJ, Easter LL, Foster CM, Gardner AW, Guo ZY, Houser KJ, Hughes LA, Kerley MK, Liu Z, Olszewski RE, Pinn I, Shaw GD, Shinpock SG, Wymore AM, Rinchik EM, Johnson DK.

    BMC Genomics. 2005 Nov 21;6:164.PMID: 16300676 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

    Gidh-Jain M, Takeda J, Xu LZ, Lange AJ, Vionnet N, Stoffel M, Froguel P, Velho G, Sun F, Cohen D, et al.

    Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1932-6.PMID: 8446612 [PubMed - indexed for MEDLINE]Related articlesFree article

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