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Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide.
Sima AA, Zhang W, Li ZG, Murakawa Y, Pierson CR.
Diabetes. 2004 Jun;53(6):1556-63.PMID: 15161761 [PubMed - indexed for MEDLINE]Related articlesFree article
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats.
Sima AA, Zhang W, Xu G, Sugimoto K, Guberski D, Yorek MA.
Diabetologia. 2000 Jun;43(6):786-93.PMID: 10907124 [PubMed - indexed for MEDLINE]Related articles
Proinsulin C-peptide replacement in type 1 diabetic BB/Wor-rats prevents deficits in nerve fiber regeneration.
Pierson CR, Zhang W, Sima AA.
J Neuropathol Exp Neurol. 2003 Jul;62(7):765-79.PMID: 12901702 [PubMed - indexed for MEDLINE]Related articles
C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat.
Sima AA, Zhang W, Sugimoto K, Henry D, Li Z, Wahren J, Grunberger G.
Diabetologia. 2001 Jul;44(7):889-97.PMID: 11508275 [PubMed - indexed for MEDLINE]Related articles
Nodal Na(+)-channel displacement is associated with nerve-conduction slowing in the chronically diabetic BB/W rat: prevention by aldose reductase inhibition.
Cherian PV, Kamijo M, Angelides KJ, Sima AA.
J Diabetes Complications. 1996 Jul-Aug;10(4):192-200.PMID: 8835918 [PubMed - indexed for MEDLINE]Related articles
Unmyelinated fiber sensory neuropathy differs in type 1 and type 2 diabetes.
Kamiya H, Murakawa Y, Zhang W, Sima AA.
Diabetes Metab Res Rev. 2005 Sep-Oct;21(5):448-58.PMID: 15747389 [PubMed - indexed for MEDLINE]Related articles
Molecular organization of the nodal region is not altered in spontaneously diabetic BB-Wistar rats.
Brown AA, Xu T, Arroyo EJ, Levinson SR, Brophy PJ, Peles E, Scherer SS.
J Neurosci Res. 2001 Jul 15;65(2):139-49.PMID: 11438983 [PubMed - indexed for MEDLINE]Related articles
C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor rats.
Stevens MJ, Zhang W, Li F, Sima AA.
Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E497-505. Epub 2004 May 4.PMID: 15126237 [PubMed - indexed for MEDLINE]Related articlesFree article
Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy.
Pierson CR, Zhang W, Murakawa Y, Sima AA.
J Neuropathol Exp Neurol. 2003 Mar;62(3):260-71.PMID: 12638730 [PubMed - indexed for MEDLINE]Related articles
Human C-peptide dose dependently prevents early neuropathy in the BB/Wor-rat.
Zhang W, Yorek M, Pierson CR, Murakawa Y, Breidenbach A, Sima AA.
Int J Exp Diabetes Res. 2001;2(3):187-93.PMID: 12369706 [PubMed - indexed for MEDLINE]Related articlesFree article
Type 1 diabetic neuropathy and C-peptide.
Sima AA, Zhang W, Grunberger G.
Exp Diabesity Res. 2004 Jan-Mar;5(1):65-77. Review.PMID: 15198372 [PubMed - indexed for MEDLINE]Related articlesFree article
C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes.
Kamiya H, Zhang W, Sima AA.
Ann Neurol. 2004 Dec;56(6):827-35.PMID: 15497155 [PubMed - indexed for MEDLINE]Related articles
C-Peptide reverses nociceptive neuropathy in type 1 diabetes.
Kamiya H, Zhang W, Ekberg K, Wahren J, Sima AA.
Diabetes. 2006 Dec;55(12):3581-7.PMID: 17130507 [PubMed - indexed for MEDLINE]Related articlesFree article
Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat.
Kappelle AC, Biessels G, Bravenboer B, van Buren T, Traber J, de Wildt DJ, Gispen WH.
Br J Pharmacol. 1994 Mar;111(3):887-93.PMID: 8019766 [PubMed - indexed for MEDLINE]Related articlesFree article
Experimental rat models of types 1 and 2 diabetes differ in sympathetic neuroaxonal dystrophy.
Schmidt RE, Dorsey DA, Beaudet LN, Parvin CA, Zhang W, Sima AA.
J Neuropathol Exp Neurol. 2004 May;63(5):450-60.PMID: 15198124 [PubMed - indexed for MEDLINE]Related articles
Reversible and irreversible nodal dysfunction in diabetic neuropathy.
Brismar T, Sima AA, Greene DA.
Ann Neurol. 1987 May;21(5):504-7.PMID: 2438993 [PubMed - indexed for MEDLINE]Related articles
Imbalances in N-CAM, SAM and polysialic acid may underlie the paranodal ion channel barrier defect in diabetic neuropathy.
Merry AC, Yamamoto K, Sima AA.
Diabetes Res Clin Pract. 1998 Jun;40(3):153-60.PMID: 9716918 [PubMed - indexed for MEDLINE]Related articles
C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats.
Zhang W, Kamiya H, Ekberg K, Wahren J, Sima AA.
Diabetes Metab Res Rev. 2007 Jan;23(1):63-70.PMID: 16845685 [PubMed - indexed for MEDLINE]Related articles
GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats.
Zhang W, Slusher B, Murakawa Y, Wozniak KM, Tsukamoto T, Jackson PF, Sima AA.
J Neurol Sci. 2002 Feb 15;194(1):21-8.PMID: 11809162 [PubMed - indexed for MEDLINE]Related articles
Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio-Breeding rat.
Sima AA, Prashar A, Zhang WX, Chakrabarti S, Greene DA.
J Clin Invest. 1990 May;85(5):1410-20.PMID: 2110189 [PubMed - indexed for MEDLINE]Related articlesFree article
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