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    Results: 1 to 20 of 612

    1.

    Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.

    Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC.

    Diabetes. 2004 Jun;53(6):1509-16.PMID: 15161755 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

    Butler AE, Janson J, Soeller WC, Butler PC.

    Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

    Matveyenko AV, Butler PC.

    Diabetes. 2006 Jul;55(7):2106-14.PMID: 16804082 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.

    Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC.

    Diabetes. 2007 May;56(5):1324-32. Epub 2007 Mar 12.PMID: 17353506 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

    Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

    Matveyenko AV, Butler PC.

    ILAR J. 2006;47(3):225-33. Review.PMID: 16804197 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

    Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC.

    Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7283-8.PMID: 8692984 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

    Ritzel RA, Butler PC.

    Diabetes. 2003 Jul;52(7):1701-8.PMID: 12829636 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

    Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

    Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.PMID: 17911343 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.

    Jaikaran ET, Clark A.

    Biochim Biophys Acta. 2001 Nov 29;1537(3):179-203. Review.PMID: 11731221 [PubMed - indexed for MEDLINE]Related articles

    11.

    High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.

    Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC.

    Diabetes. 2007 Aug;56(8):2016-27. Epub 2007 May 2.PMID: 17475933 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

    Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

    Diabetes. 2009 Apr;58(4):906-16. Epub 2009 Jan 16.PMID: 19151199 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus.

    Johnson KH, O'Brien TD, Betsholtz C, Westermark P.

    Lab Invest. 1992 May;66(5):522-35. Review.PMID: 1573849 [PubMed - indexed for MEDLINE]Related articles

    14.

    Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitus.

    Hayden MR, Karuparthi PR, Manrique CM, Lastra G, Habibi J, Sowers JR.

    Exp Biol Med (Maywood). 2007 Jun;232(6):772-9.PMID: 17526769 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

    Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

    Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

    16.

    Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

    Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE.

    Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3492-6.PMID: 8622964 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

    Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC.

    Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1317-24. Epub 2006 Jul 18.PMID: 16849627 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.

    Haataja L, Gurlo T, Huang CJ, Butler PC.

    Endocr Rev. 2008 May;29(3):303-16. Epub 2008 Feb 26. Review.PMID: 18314421 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

    de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

    Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice.

    Höppener JW, Oosterwijk C, van Hulst KL, Verbeek JS, Capel PJ, de Koning EJ, Clark A, Jansz HS, Lips CJ.

    J Cell Biochem. 1994;55 Suppl:39-53. Review.PMID: 7929617 [PubMed - indexed for MEDLINE]Related articles

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