PubMed

The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes.

Palmer G, Burger D, Mezin F, Magne D, Gabay C, Dayer JM, Guerne PA.

Arthritis Res Ther. 2004;6(3):R181-9. Epub 2004 Feb 19.PMID: 15142263 [PubMed - indexed for MEDLINE]Related articlesFree article

The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha.

Magne D, Mézin F, Palmer G, Guerne PA.

Inflamm Res. 2006 Nov;55(11):469-75.PMID: 17122964 [PubMed - indexed for MEDLINE]Related articles

Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion.

Woolley DE, Tetlow LC.

Arthritis Res. 2000;2(1):65-74.PMID: 11219391 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1beta stimulated rheumatoid synovial fibroblasts.

Migita K, Miyashita T, Ishibashi H, Maeda Y, Nakamura M, Yatsuhashi H, Ida H, Kawakami A, Aoyagi T, Kawabe Y, Eguchi K.

Clin Exp Immunol. 2004 Sep;137(3):612-6.PMID: 15320915 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.

Vergne-Salle P, Léger DY, Bertin P, Trèves R, Beneytout JL, Liagre B.

Cytokine. 2005 Sep 7;31(5):335-48.PMID: 16099671 [PubMed - indexed for MEDLINE]Related articles

The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes.

Burger D, Begué-Pastor N, Benavent S, Gruaz L, Kaufmann MT, Chicheportiche R, Dayer JM.

Rheumatology (Oxford). 2003 Jan;42(1):89-96.PMID: 12509619 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon beta stimulates interleukin 1 receptor antagonist production in human articular chondrocytes and synovial fibroblasts.

Palmer G, Mezin F, Juge-Aubry CE, Plater-Zyberk C, Gabay C, Guerne PA.

Ann Rheum Dis. 2004 Jan;63(1):43-9.PMID: 14672890 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis.

Cutolo M, Sulli A, Ghiorzo P, Pizzorni C, Craviotto C, Villaggio B.

Ann Rheum Dis. 2003 Apr;62(4):297-302.PMID: 12634225 [PubMed - indexed for MEDLINE]Related articlesFree article

Production of interleukin-1 receptor antagonist by human articular chondrocytes.

Palmer G, Guerne PA, Mezin F, Maret M, Guicheux J, Goldring MB, Gabay C.

Arthritis Res. 2002;4(3):226-31. Epub 2002 Apr 8.PMID: 12010575 [PubMed - indexed for MEDLINE]Related articlesFree article

Production of intracellular IL-1alpha, IL-1beta, and IL-1Ra isoforms by activated human dermal and synovial fibroblasts: phenotypic differences between human dermal and synovial fibroblasts.

Maret M, Chicheportiche R, Dayer JM, Gabay C.

Cytokine. 2004 Mar 7;25(5):193-203.PMID: 15036245 [PubMed - indexed for MEDLINE]Related articles

In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.

Martel-Pelletier J, Mineau F, Jolicoeur FC, Cloutier JM, Pelletier JP.

J Rheumatol. 1998 Apr;25(4):753-62.PMID: 9558181 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism.

Moulin D, Bianchi A, Boyault S, Sebillaud S, Koufany M, Francois M, Netter P, Jouzeau JY, Terlain B.

Arthritis Rheum. 2005 Mar;52(3):759-69.PMID: 15751073 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts.

Neidhart M, Gay RE, Gay S.

Arthritis Rheum. 2000 Aug;43(8):1719-28.PMID: 10943861 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.

He W, Pelletier JP, Martel-Pelletier J, Laufer S, Di Battista JA.

J Rheumatol. 2002 Mar;29(3):546-53.PMID: 11908571 [PubMed - indexed for MEDLINE]Related articles

Active leflunomide metabolite inhibits interleukin 1beta, tumour necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures.

Elkayam O, Yaron I, Shirazi I, Judovitch R, Caspi D, Yaron M.

Ann Rheum Dis. 2003 May;62(5):440-3.PMID: 12695157 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of human chondrocyte metabolism by recombinant human interferon.

Henrotin YE, Zheng SX, Labasse AH, Deby GP, Crielaard JM, Reginster JY.

Osteoarthritis Cartilage. 2000 Nov;8(6):474-82.PMID: 11069732 [PubMed - indexed for MEDLINE]Related articles

Analysis of the cytokine network among tumor necrosis factor alpha, interleukin-1beta, interleukin-8, and interleukin-1 receptor antagonist in monosodium urate crystal-induced rabbit arthritis.

Matsukawa A, Yoshimura T, Maeda T, Takahashi T, Ohkawara S, Yoshinaga M.

Lab Invest. 1998 May;78(5):559-69.PMID: 9605181 [PubMed - indexed for MEDLINE]Related articles

Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritis synovium and synovial fibroblasts.

Jovanovic D, Pelletier JP, Alaaeddine N, Mineau F, Geng C, Ranger P, Martel-Pelletier J.

Osteoarthritis Cartilage. 1998 Jan;6(1):40-9.PMID: 9616438 [PubMed - indexed for MEDLINE]Related articles

Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast IL-6 production by distinct mechanisms.

Miljkovic Dj, Samardzic T, Drakulic D, Stosic-Grujicic S, Trajkovic V.

Cytokine. 2002 Aug 21;19(4):181-6.PMID: 12297111 [PubMed - indexed for MEDLINE]Related articles

Mechanism of the antiproliferative action of leflunomide. A77 1726, the active metabolite of leflunomide, does not block T-cell receptor-mediated signal transduction but its antiproliferative effects are antagonized by pyrimidine nucleosides.

Cao WW, Kao PN, Chao AC, Gardner P, Ng J, Morris RE.

J Heart Lung Transplant. 1995 Nov-Dec;14(6 Pt 1):1016-30.PMID: 8719445 [PubMed - indexed for MEDLINE]Related articles