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    Results: 1 to 20 of 399

    1.

    Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

    Pearson ER, Badman MK, Lockwood CR, Clark PM, Ellard S, Bingham C, Hattersley AT.

    Diabetes Care. 2004 May;27(5):1102-7.PMID: 15111528 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

    Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT.

    Diabetes. 2001 Feb;50 Suppl 1:S101-7.PMID: 11272165 [PubMed - indexed for MEDLINE]Related articles

    3.

    Genetic cause of hyperglycaemia and response to treatment in diabetes.

    Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, Hattersley AT.

    Lancet. 2003 Oct 18;362(9392):1275-81.PMID: 14575972 [PubMed - indexed for MEDLINE]Related articles

    4.

    The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria.

    Bingham C, Ellard S, Nicholls AJ, Pennock CA, Allen J, James AJ, Satchell SC, Salzmann MB, Hattersley AT.

    Diabetes. 2001 Sep;50(9):2047-52.PMID: 11522670 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.

    Stride A, Ellard S, Clark P, Shakespeare L, Salzmann M, Shepherd M, Hattersley AT.

    Diabetes Care. 2005 Jul;28(7):1751-6.PMID: 15983330 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.

    Rissanen J, Wang H, Miettinen R, Kärkkäinen P, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Uusitupa M, Laakso M.

    Diabetes Care. 2000 Oct;23(10):1533-8.PMID: 11023148 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

    Frayling TM, Evans JC, Bulman MP, Pearson E, Allen L, Owen K, Bingham C, Hannemann M, Shepherd M, Ellard S, Hattersley AT.

    Diabetes. 2001 Feb;50 Suppl 1:S94-100.PMID: 11272211 [PubMed - indexed for MEDLINE]Related articles

    8.

    Mutations in the genes for hepatocyte nuclear factor (HNF)-1alpha, -4alpha, -1beta, and -3beta; the dimerization cofactor of HNF-1; and insulin promoter factor 1 are not common causes of early-onset type 2 diabetes in Pima Indians.

    Baier LJ, Permana PA, Traurig M, Dobberfuhl A, Wiedrich C, Sutherland J, Thuillez P, Luczy-Bachman G, Hara M, Horikawa Y, Hinokio Y, Hanson RL, Bogardus C.

    Diabetes Care. 2000 Mar;23(3):302-4.PMID: 10868855 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.

    Sagen JV, Pearson ER, Johansen A, Spyer G, Søvik O, Pedersen O, Njølstad PR, Hattersley AT, Hansen T.

    Diabet Med. 2005 Apr;22(4):406-9.PMID: 15787664 [PubMed - indexed for MEDLINE]Related articles

    10.

    A low renal threshold for glucose in diabetic patients with a mutation in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene.

    Menzel R, Kaisaki PJ, Rjasanowski I, Heinke P, Kerner W, Menzel S.

    Diabet Med. 1998 Oct;15(10):816-20.PMID: 9796880 [PubMed - indexed for MEDLINE]Related articles

    11.

    Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes.

    Doria A, Yang Y, Malecki M, Scotti S, Dreyfus J, O'Keeffe C, Orban T, Warram JH, Krolewski AS.

    Diabetes Care. 1999 Feb;22(2):253-61.PMID: 10333942 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    The genetic abnormality in the beta cell determines the response to an oral glucose load.

    Stride A, Vaxillaire M, Tuomi T, Barbetti F, Njølstad PR, Hansen T, Costa A, Conget I, Pedersen O, Søvik O, Lorini R, Groop L, Froguel P, Hattersley AT.

    Diabetologia. 2002 Mar;45(3):427-35.PMID: 11914749 [PubMed - indexed for MEDLINE]Related articles

    13.

    Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.

    Hansen T, Eiberg H, Rouard M, Vaxillaire M, Møller AM, Rasmussen SK, Fridberg M, Urhammer SA, Holst JJ, Almind K, Echwald SM, Hansen L, Bell GI, Pedersen O.

    Diabetes. 1997 Apr;46(4):726-30.PMID: 9075819 [PubMed - indexed for MEDLINE]Related articles

    14.

    Studies of the variability of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function.

    Ek J, Grarup N, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O.

    Hum Mutat. 2001 Oct;18(4):356-7.PMID: 11668623 [PubMed - indexed for MEDLINE]Related articles

    15.

    Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

    Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

    Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.PMID: 11904435 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.

    Yoshiuchi I, Yamagata K, Yang Q, Iwahashi H, Okita K, Yamamoto K, Oue T, Imagawa A, Hamaguchi T, Yamasaki T, Horikawa Y, Satoh T, Nakajima H, Miyazaki J, Higashiyama S, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y.

    Diabetologia. 1999 May;42(5):621-6.PMID: 10333057 [PubMed - indexed for MEDLINE]Related articles

    17.

    A prevalent amino acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge.

    Urhammer SA, Fridberg M, Hansen T, Rasmussen SK, Møller AM, Clausen JO, Pedersen O.

    Diabetes. 1997 May;46(5):912-6.PMID: 9133564 [PubMed - indexed for MEDLINE]Related articles

    18.

    Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations.

    Brackenridge A, Pearson ER, Shojaee-Moradie F, Hattersley AT, Russell-Jones D, Umpleby AM.

    Diabetes. 2006 Feb;55(2):405-11.PMID: 16443774 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

    Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS.

    J Clin Invest. 1998 May 15;101(10):2215-22.PMID: 9593777 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.

    Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M.

    Diabetes. 2003 Dec;52(12):2989-95.PMID: 14633861 [PubMed - indexed for MEDLINE]Related articlesFree article

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