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    Results: 1 to 20 of 257

    1.

    Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

    Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

    Diabetes. 2004 May;53(5):1326-35.PMID: 15111503 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.

    Hansotia T, Drucker DJ.

    Regul Pept. 2005 Jun 15;128(2):125-34. Review.PMID: 15780432 [PubMed - indexed for MEDLINE]Related articles

    3.

    Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice.

    Flock G, Baggio LL, Longuet C, Drucker DJ.

    Diabetes. 2007 Dec;56(12):3006-13. Epub 2007 Aug 23.PMID: 17717280 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure.

    Hansotia T, Maida A, Flock G, Yamada Y, Tsukiyama K, Seino Y, Drucker DJ.

    J Clin Invest. 2007 Jan;117(1):143-52. Epub 2006 Dec 21.PMID: 17187081 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

    Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA.

    Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. Epub 2003 Jan 21.PMID: 12540373 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice.

    Liu X, Harada N, Yamane S, Kitajima L, Uchida S, Hamasaki A, Mukai E, Toyoda K, Yamada C, Yamada Y, Seino Y, Inagaki N.

    Life Sci. 2009 Jun 19;84(25-26):876-81. Epub 2009 Apr 7.PMID: 19358859 [PubMed - indexed for MEDLINE]Related articles

    7.

    Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice.

    Lamont BJ, Drucker DJ.

    Diabetes. 2008 Jan;57(1):190-8. Epub 2007 Oct 10.PMID: 17928394 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptide in mice.

    Ahrén B, Hughes TE.

    Endocrinology. 2005 Apr;146(4):2055-9. Epub 2004 Dec 16.PMID: 15604213 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Insulin action in the double incretin receptor knockout mouse.

    Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ.

    Diabetes. 2008 Feb;57(2):288-97. Epub 2007 Oct 31.PMID: 17977951 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

    Pederson RA, Satkunarajah M, McIntosh CH, Scrocchi LA, Flamez D, Schuit F, Drucker DJ, Wheeler MB.

    Diabetes. 1998 Jul;47(7):1046-52.PMID: 9648827 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.

    Baggio LL, Kim JG, Drucker DJ.

    Diabetes. 2004 Dec;53 Suppl 3:S205-14.PMID: 15561912 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs.

    Deacon CF, Wamberg S, Bie P, Hughes TE, Holst JJ.

    J Endocrinol. 2002 Feb;172(2):355-62.PMID: 11834453 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

    Li Y, Cao X, Li LX, Brubaker PL, Edlund H, Drucker DJ.

    Diabetes. 2005 Feb;54(2):482-91.PMID: 15677506 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors.

    Holst JJ.

    Expert Opin Emerg Drugs. 2004 May;9(1):155-66. Review.PMID: 15155141 [PubMed - indexed for MEDLINE]Related articles

    15.

    The incretin system and its role in type 2 diabetes mellitus.

    Holst JJ, Vilsbøll T, Deacon CF.

    Mol Cell Endocrinol. 2009 Jan 15;297(1-2):127-36. Epub 2008 Aug 20. Review.PMID: 18786605 [PubMed - indexed for MEDLINE]Related articles

    16.

    Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.

    Baggio L, Kieffer TJ, Drucker DJ.

    Endocrinology. 2000 Oct;141(10):3703-9.PMID: 11014225 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.

    Scrocchi LA, Hill ME, Saleh J, Perkins B, Drucker DJ.

    Diabetes. 2000 Sep;49(9):1552-60.PMID: 10969840 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Incretin mimetics and DPP-4 inhibitors: new approach to treatment of type 2 diabetes mellitus.

    Siddiqui NI.

    Mymensingh Med J. 2009 Jan;18(1):113-24. Review.PMID: 19182763 [PubMed - indexed for MEDLINE]Related articles

    19.

    Enhancing incretin action for the treatment of type 2 diabetes.

    Drucker DJ.

    Diabetes Care. 2003 Oct;26(10):2929-40. Review.PMID: 14514604 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors.

    Neumiller JJ.

    J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S16-29. Review.PMID: 19801361 [PubMed - indexed for MEDLINE]Related articlesFree article

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