PubMed

Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice.

Emanueli C, Graiani G, Salis MB, Gadau S, Desortes E, Madeddu P.

Diabetes. 2004 Apr;53(4):1096-103.PMID: 15047627 [PubMed - indexed for MEDLINE]Related articlesFree article

Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia.

Emanueli C, Caporali A, Krankel N, Cristofaro B, Van Linthout S, Madeddu P.

Front Biosci. 2007 Jan 1;12:2003-12.PMID: 17127438 [PubMed - indexed for MEDLINE]Related articles

Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer.

Emanueli C, Salis MB, Van Linthout S, Meloni M, Desortes E, Silvestre JS, Clergue M, Figueroa CD, Gadau S, Condorelli G, Madeddu P.

Circulation. 2004 Sep 21;110(12):1638-44. Epub 2004 Sep 13.PMID: 15364809 [PubMed - indexed for MEDLINE]Related articlesFree article

Nerve growth factor supplementation reverses the impairment, induced by Type 1 diabetes, of hindlimb post-ischaemic recovery in mice.

Salis MB, Graiani G, Desortes E, Caldwell RB, Madeddu P, Emanueli C.

Diabetologia. 2004 Jun;47(6):1055-63. Epub 2004 Jun 8.PMID: 15184980 [PubMed - indexed for MEDLINE]Related articles

Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer.

Emanueli C, Salis MB, Pinna A, Stacca T, Milia AF, Spano A, Chao J, Chao L, Sciola L, Madeddu P.

Circulation. 2002 Aug 20;106(8):993-9.PMID: 12186806 [PubMed - indexed for MEDLINE]Related articlesFree article

Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression.

Fujii T, Onimaru M, Yonemitsu Y, Kuwano H, Sueishi K.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2785-91. Epub 2008 Apr 25.PMID: 18441206 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles.

Caporali A, Pani E, Horrevoets AJ, Kraenkel N, Oikawa A, Sala-Newby GB, Meloni M, Cristofaro B, Graiani G, Leroyer AS, Boulanger CM, Spinetti G, Yoon SO, Madeddu P, Emanueli C.

Circ Res. 2008 Jul 18;103(2):e15-26. Epub 2008 Jun 19.PMID: 18566344 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization.

Hiasa K, Ishibashi M, Ohtani K, Inoue S, Zhao Q, Kitamoto S, Sata M, Ichiki T, Takeshita A, Egashira K.

Circulation. 2004 May 25;109(20):2454-61. Epub 2004 May 17.PMID: 15148275 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice.

Luo JD, Wang YY, Fu WL, Wu J, Chen AF.

Circulation. 2004 Oct 19;110(16):2484-93. Epub 2004 Jul 19.PMID: 15262829 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice.

Emanueli C, Monopoli A, Kraenkel N, Meloni M, Gadau S, Campesi I, Ongini E, Madeddu P.

Br J Pharmacol. 2007 Apr;150(7):873-82. Epub 2007 Mar 12.PMID: 17351667 [PubMed - indexed for MEDLINE]Related articlesFree article

Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene.

Qian HS, Liu P, Huw LY, Orme A, Halks-Miller M, Hill SM, Jin F, Kretschmer P, Blasko E, Cashion L, Szymanski P, Vergona R, Harkins R, Yu J, Sessa WC, Dole WP, Rubanyi GM, Kauser K.

Gene Ther. 2006 Sep;13(18):1342-50. Epub 2006 Apr 27.PMID: 16642030 [PubMed - indexed for MEDLINE]Related articles

Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis.

Gadau S, Emanueli C, Van Linthout S, Graiani G, Todaro M, Meloni M, Campesi I, Invernici G, Spillmann F, Ward K, Madeddu P.

Diabetologia. 2006 Feb;49(2):405-20. Epub 2006 Jan 17.PMID: 16416271 [PubMed - indexed for MEDLINE]Related articles

Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.

Spillmann F, Graiani G, Van Linthout S, Meloni M, Campesi I, Lagrasta C, Westermann D, Tschöpe C, Quaini F, Emanueli C, Madeddu P.

Regen Med. 2006 Mar;1(2):235-54.PMID: 17465807 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone ameliorates endothelial dysfunction and restores ischemia-induced angiogenesis in diabetic mice.

Huang PH, Sata M, Nishimatsu H, Sumi M, Hirata Y, Nagai R.

Biomed Pharmacother. 2008 Jan;62(1):46-52. Epub 2007 Jul 20.PMID: 17692499 [PubMed - indexed for MEDLINE]Related articles

Optimization of adenovirus-mediated endothelial nitric oxide synthase delivery in rat hindlimb ischemia.

Yan J, Tang GL, Wang R, Messina LM.

Gene Ther. 2005 Nov;12(22):1640-50.PMID: 16107865 [PubMed - indexed for MEDLINE]Related articles

Telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia.

Zaccagnini G, Gaetano C, Della Pietra L, Nanni S, Grasselli A, Mangoni A, Benvenuto R, Fabrizi M, Truffa S, Germani A, Moretti F, Pontecorvi A, Sacchi A, Bacchetti S, Capogrossi MC, Farsetti A.

J Biol Chem. 2005 Apr 15;280(15):14790-8. Epub 2005 Feb 1.PMID: 15687494 [PubMed - indexed for MEDLINE]Related articlesFree article

Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer.

Emanueli C, Salis MB, Stacca T, Gaspa L, Chao J, Chao L, Piana A, Madeddu P.

Hypertension. 2001 Jul;38(1):136-41.PMID: 11463774 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of neovascularization with mobilized blood cells transplantaion: supply of angioblasts and angiogenic cytokines.

Zhou B, Liu PX, Lan HF, Fang ZH, Han ZB, Ren H, Poon MC, Han ZC.

J Cell Biochem. 2007 Sep 1;102(1):183-95.PMID: 17390342 [PubMed - indexed for MEDLINE]Related articles

Local delivery of human tissue kallikrein gene accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia.

Emanueli C, Minasi A, Zacheo A, Chao J, Chao L, Salis MB, Straino S, Tozzi MG, Smith R, Gaspa L, Bianchini G, Stillo F, Capogrossi MC, Madeddu P.

Circulation. 2001 Jan 2;103(1):125-32.PMID: 11136697 [PubMed - indexed for MEDLINE]Related articlesFree article

Autologous bone marrow cell implantation as therapeutic angiogenesis for ischemic hindlimb in diabetic rat model.

Hirata K, Li TS, Nishida M, Ito H, Matsuzaki M, Kasaoka S, Hamano K.

Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H66-70. Epub 2002 Sep 19.PMID: 12388231 [PubMed - indexed for MEDLINE]Related articlesFree article