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    Results: 1 to 20 of 167

    1.

    Improved beta-cell survival and reduced insulitis in a type 1 diabetic rat model after treatment with a beta-cell-selective K(ATP) channel opener.

    Skak K, Gotfredsen CF, Lundsgaard D, Hansen JB, Sturis J, Markholst H.

    Diabetes. 2004 Apr;53(4):1089-95.PMID: 15047626 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

    Alemzadeh R, Fledelius C, Bodvarsdottir T, Sturis J.

    Metabolism. 2004 Apr;53(4):441-7.PMID: 15045689 [PubMed - indexed for MEDLINE]Related articles

    3.

    NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

    Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.

    Diabetes. 2003 Oct;52(10):2513-8.PMID: 14514634 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

    Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

    J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Functional rest through intensive treatment with insulin and potassium channel openers preserves residual beta-cell function and mass in acutely diabetic BB rats.

    Rasmussen SB, Sørensen TS, Hansen JB, Mandrup-Poulsen T, Hornum L, Markholst H.

    Horm Metab Res. 2000 Jul;32(7):294-300.PMID: 10965937 [PubMed - indexed for MEDLINE]Related articles

    6.

    Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

    Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

    Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Insulitis and mechanisms of disease resistance: studies in an animal model of insulin dependent diabetes mellitus.

    Bone AJ, Hitchcock PR, Gwilliam DJ, Cunningham JM, Barley J.

    J Mol Med. 1999 Jan;77(1):57-61.PMID: 9930928 [PubMed - indexed for MEDLINE]Related articles

    8.

    Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

    Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.

    Diabetes. 2008 Dec;57(12):3327-34. Epub 2008 Sep 5.PMID: 18776135 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.

    Nielsen FE, Ebdrup S, Jensen AF, Ynddal L, Bodvarsdottir TB, Stidsen C, Worsaae A, Boonen HC, Arkhammar PO, Fremming T, Wahl P, Kornø HT, Hansen JB.

    J Med Chem. 2006 Jul 13;49(14):4127-39.PMID: 16821773 [PubMed - indexed for MEDLINE]Related articles

    10.

    Openers of ATP-dependent K+-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetes.

    Björklund A, Bondo Hansen J, Falkmer S, Grill V.

    Diabetologia. 2004 May;47(5):885-91. Epub 2004 Apr 16.PMID: 15088085 [PubMed - indexed for MEDLINE]Related articles

    11.

    Long-term prophylactic insulin treatment can prevent spontaneous diabetes and thyroiditis development in the diabetes-prone bio-breeding rat, while short-term treatment is ineffective.

    Visser J, Klatter F, Vis L, Groen H, Strubbe J, Rozing J.

    Eur J Endocrinol. 2003 Sep;149(3):223-9.PMID: 12943525 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    The BBZ/Wor rat: clinical characteristics of the diabetic syndrome.

    Guberski DL, Butler L, Manzi SM, Stubbs M, Like AA.

    Diabetologia. 1993 Oct;36(10):912-9.PMID: 8243869 [PubMed - indexed for MEDLINE]Related articles

    13.

    Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin-induced diabetes.

    Matsuda M, Kawasaki F, Mikami Y, Takeuchi Y, Saito M, Eto M, Kaku K.

    Eur J Pharmacol. 2002 Oct 18;453(1):141-8.PMID: 12393069 [PubMed - indexed for MEDLINE]Related articles

    14.

    The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects.

    Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A, Dyrberg T.

    J Clin Pharmacol. 2005 Jul;45(7):763-72.PMID: 15951466 [PubMed - indexed for MEDLINE]Related articles

    15.

    Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats.

    Kuntz E, Pinget M, Damgé P.

    JOP. 2004 Nov 10;5(6):464-75.PMID: 15536283 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Preservation of GLUT 2 expression in islet beta cells of Kilham rat virus (KRV)-infected diabetes-resistant BB/Wor rats.

    Stubbs M, Guberski DL, Like AA.

    Diabetologia. 1994 Dec;37(12):1186-94.PMID: 7895947 [PubMed - indexed for MEDLINE]Related articles

    17.

    Prophylactic insulin treatment of syngeneically transplanted pre-diabetic BB-DP rats.

    Sparre T, Sprinkel AM, Christensen UB, Karlsen AE, Pociot F, Nerup J.

    Autoimmunity. 2003 Mar;36(2):99-109.PMID: 12820692 [PubMed - indexed for MEDLINE]Related articles

    18.

    Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

    McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS.

    Diabetes. 2005 Nov;54(11):3169-74.PMID: 16249441 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Prospective investigations of long-term normoglycaemic BB/OK-rats: serial determination of glucose tolerance, insulitis, B-cell volume density and pancreatic insulin content.

    Hahn HJ, Lucke S, Klöting I, Besch W.

    Exp Clin Endocrinol. 1991;98(3):185-92.PMID: 1778238 [PubMed - indexed for MEDLINE]Related articles

    20.

    Glucose-induced insulin secretion is potentiated by a new imidazoline compound.

    Mest HJ, Raap A, Schloos J, Treinies I, Paal M, Giese U, Koivisto V.

    Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364(1):47-52.PMID: 11485038 [PubMed - indexed for MEDLINE]Related articles

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