PubMed

Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo.

Kim HJ, Higashimori T, Park SY, Choi H, Dong J, Kim YJ, Noh HL, Cho YR, Cline G, Kim YB, Kim JK.

Diabetes. 2004 Apr;53(4):1060-7.PMID: 15047622 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice.

Kim JK, Fillmore JJ, Gavrilova O, Chao L, Higashimori T, Choi H, Kim HJ, Yu C, Chen Y, Qu X, Haluzik M, Reitman ML, Shulman GI.

Diabetes. 2003 Jun;52(6):1311-8.PMID: 12765938 [PubMed - indexed for MEDLINE]Related articlesFree article

PKC-theta knockout mice are protected from fat-induced insulin resistance.

Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI.

J Clin Invest. 2004 Sep;114(6):823-7.PMID: 15372106 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance.

Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7522-7. Epub 2001 Jun 5.PMID: 11390966 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding.

Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW.

Diabetes. 1997 Nov;46(11):1768-74.PMID: 9356024 [PubMed - indexed for MEDLINE]Related articles

Prevention of fat-induced insulin resistance by salicylate.

Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI.

J Clin Invest. 2001 Aug;108(3):437-46.PMID: 11489937 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats.

Rotter Sopasakis V, Larsson BM, Johansson A, Holmäng A, Smith U.

Diabetologia. 2004 Nov;47(11):1879-87. Epub 2004 Nov 17.PMID: 15551046 [PubMed - indexed for MEDLINE]Related articles

Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle.

Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Lorenzo M.

Diabetes. 2008 Dec;57(12):3211-21. Epub 2008 Sep 16.PMID: 18796617 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH.

Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.PMID: 18952837 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase.

Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G, Prelovsek O, Hohnen-Behrens C, Watt MJ, James DE, Kemp BE, Pedersen BK, Febbraio MA.

Diabetes. 2006 Oct;55(10):2688-97.PMID: 17003332 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.

Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK.

Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E30-9. Epub 2005 Feb 8.PMID: 15701680 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression.

Yuen DY, Dwyer RM, Matthews VB, Zhang L, Drew BG, Neill B, Kingwell BA, Clark MG, Rattigan S, Febbraio MA.

Diabetes. 2009 May;58(5):1086-95. Epub 2009 Feb 2.PMID: 19188427 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated fasting insulin concentrations associate with impaired insulin signaling in skeletal muscle of healthy subjects independent of obesity.

Korsheninnikova E, Seppälä-Lindroos A, Vehkavaara S, Goto T, Virkamäki A.

Diabetes Metab Res Rev. 2002 May-Jun;18(3):209-16.PMID: 12112939 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.

Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI.

Diabetes. 2008 Oct;57(10):2644-51. Epub 2008 Jul 15.PMID: 18633112 [PubMed - indexed for MEDLINE]Related articlesFree article

L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity.

Prada PO, Hirabara SM, de Souza CT, Schenka AA, Zecchin HG, Vassallo J, Velloso LA, Carneiro E, Carvalheira JB, Curi R, Saad MJ.

Diabetologia. 2007 Sep;50(9):1949-59. Epub 2007 Jun 29.PMID: 17604977 [PubMed - indexed for MEDLINE]Related articles

Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle.

Capozza F, Combs TP, Cohen AW, Cho YR, Park SY, Schubert W, Williams TM, Brasaemle DL, Jelicks LA, Scherer PE, Kim JK, Lisanti MP.

Am J Physiol Cell Physiol. 2005 Jun;288(6):C1317-31. Epub 2005 Feb 2.PMID: 15689413 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice.

Klover PJ, Zimmers TA, Koniaris LG, Mooney RA.

Diabetes. 2003 Nov;52(11):2784-9.PMID: 14578297 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 depletion selectively improves hepatic insulin action in obesity.

Klover PJ, Clementi AH, Mooney RA.

Endocrinology. 2005 Aug;146(8):3417-27. Epub 2005 Apr 21.PMID: 15845623 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.

Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED.

J Biol Chem. 2006 Mar 17;281(11):7060-7. Epub 2006 Jan 17.PMID: 16418171 [PubMed - indexed for MEDLINE]Related articlesFree article

Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling.

Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH.

Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E233-40.PMID: 12110527 [PubMed - indexed for MEDLINE]Related articlesFree article