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Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle.
Arias EB, Kim J, Cartee GD.
Diabetes. 2004 Apr;53(4):921-30.PMID: 15047606 [PubMed - indexed for MEDLINE]Related articlesFree article
Relationship between protein O-linked glycosylation and insulin-stimulated glucose transport in rat skeletal muscle following calorie restriction or exposure to O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate.
Arias EB, Cartee GD.
Acta Physiol Scand. 2005 Mar;183(3):281-9.PMID: 15743388 [PubMed - indexed for MEDLINE]Related articles
O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes.
Park SY, Ryu J, Lee W.
Exp Mol Med. 2005 Jun 30;37(3):220-9.PMID: 16000877 [PubMed - indexed for MEDLINE]Related articlesFree article
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes.
Vosseller K, Wells L, Lane MD, Hart GW.
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5313-8.PMID: 11959983 [PubMed - indexed for MEDLINE]Related articlesFree article
Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells.
Matthews JA, Belof JL, Acevedo-Duncan M, Potter RL.
Mol Cell Biochem. 2007 Apr;298(1-2):109-23. Epub 2006 Nov 30.PMID: 17136481 [PubMed - indexed for MEDLINE]Related articles
Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate.
Haltiwanger RS, Grove K, Philipsberg GA.
J Biol Chem. 1998 Feb 6;273(6):3611-7.PMID: 9452489 [PubMed - indexed for MEDLINE]Related articlesFree article
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.
Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ.
J Biol Chem. 2008 Dec 12;283(50):34687-95. Epub 2008 Oct 8.PMID: 18842583 [PubMed - indexed for MEDLINE]Related articles
Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury.
Xing D, Feng W, Nöt LG, Miller AP, Zhang Y, Chen YF, Majid-Hassan E, Chatham JC, Oparil S.
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H335-42. Epub 2008 May 9.PMID: 18469144 [PubMed - indexed for MEDLINE]Related articlesFree article
Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1.
Gandy JC, Rountree AE, Bijur GN.
FEBS Lett. 2006 May 29;580(13):3051-8. Epub 2006 Apr 27.PMID: 16684529 [PubMed - indexed for MEDLINE]Related articlesFree article
Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity.
Bruss MD, Arias EB, Lienhard GE, Cartee GD.
Diabetes. 2005 Jan;54(1):41-50.PMID: 15616009 [PubMed - indexed for MEDLINE]Related articlesFree article
The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels.
Zou L, Yang S, Hu S, Chaudry IH, Marchase RB, Chatham JC.
Shock. 2007 Apr;27(4):402-8.PMID: 17414423 [PubMed - indexed for MEDLINE]Related articles
Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.
Dokken BB, Sloniger JA, Henriksen EJ.
Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1188-94. Epub 2005 Jan 25.PMID: 15671078 [PubMed - indexed for MEDLINE]Related articlesFree article
The HIV protease inhibitor indinavir decreases insulin- and contraction-stimulated glucose transport in skeletal muscle.
Nolte LA, Yarasheski KE, Kawanaka K, Fisher J, Le N, Holloszy JO.
Diabetes. 2001 Jun;50(6):1397-401.PMID: 11375341 [PubMed - indexed for MEDLINE]Related articlesFree article
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.
Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ.
J Am Chem Soc. 2007 Jan 24;129(3):635-44.PMID: 17227027 [PubMed - indexed for MEDLINE]Related articles
Selective decrease of membrane-associated PKC-alpha and PKC-epsilon in response to elevated intracellular O-GlcNAc levels in transformed human glial cells.
Matthews JA, Acevedo-Duncan M, Potter RL.
Biochim Biophys Acta. 2005 Apr 15;1743(3):305-15. Epub 2004 Dec 2.PMID: 15843043 [PubMed - indexed for MEDLINE]Related articles
Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats.
Akimoto Y, Hart GW, Wells L, Vosseller K, Yamamoto K, Munetomo E, Ohara-Imaizumi M, Nishiwaki C, Nagamatsu S, Hirano H, Kawakami H.
Glycobiology. 2007 Feb;17(2):127-40. Epub 2006 Nov 9.PMID: 17095531 [PubMed - indexed for MEDLINE]Related articlesFree article
Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle.
Funai K, Schweitzer GG, Sharma N, Kanzaki M, Cartee GD.
Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E242-51. Epub 2009 May 12.PMID: 19435856 [PubMed - indexed for MEDLINE]Related articles
Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS-AS160 in rat skeletal muscle.
Funai K, Cartee GD.
Diabetes. 2009 May;58(5):1096-104. Epub 2009 Feb 10.PMID: 19208911 [PubMed - indexed for MEDLINE]Related articlesFree article
Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle.
Arias EB, Kim J, Funai K, Cartee GD.
Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1191-200. Epub 2006 Dec 19.PMID: 17179389 [PubMed - indexed for MEDLINE]Related articlesFree article
Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes.
Robinson KA, Ball LE, Buse MG.
Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E884-90. Epub 2006 Nov 22.PMID: 17122093 [PubMed - indexed for MEDLINE]Related articlesFree article
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