PubMed

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.

Eftychi C, Howson JM, Barratt BJ, Vella A, Payne F, Smyth DJ, Twells RC, Walker NM, Rance HE, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîirgovişte C, Savage DA, Todd JA.

Diabetes. 2004 Mar;53(3):870-3.PMID: 14988278 [PubMed - indexed for MEDLINE]Related articlesFree article

IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?

Johansen A, Jensen DP, Bergholdt R, Mortensen HB, Pociot F, Nerup J, Hansen T, Pedersen O; Danish Society of Childhood Diabetes.

Diabetes Obes Metab. 2006 Jan;8(1):75-82.PMID: 16367885 [PubMed - indexed for MEDLINE]Related articles

Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.

Shaat N, Ekelund M, Lernmark A, Ivarsson S, Almgren P, Berntorp K, Groop L.

Diabetologia. 2005 Dec;48(12):2544-51. Epub 2005 Nov 17.PMID: 16320083 [PubMed - indexed for MEDLINE]Related articles

[Association of Pro12Ala variant in peroxisome proliferator-activated receptor-gamma2 gene with type 2 diabetes mellitus]

Fu M, Chen H, Li X, Li J, Wu B, Cheng L, Cai M, Fu Z.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Jun;19(3):234-8. Chinese. PMID: 12048686 [PubMed - indexed for MEDLINE]Related articles

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth.

Eriksson JG, Lindi V, Uusitupa M, Forsén TJ, Laakso M, Osmond C, Barker DJ.

Diabetes. 2002 Jul;51(7):2321-4.PMID: 12086968 [PubMed - indexed for MEDLINE]Related articlesFree article

E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

Love-Gregory L, Wasson J, Lin J, Skolnick G, Suarez B, Permutt MA.

Diabetologia. 2003 Jan;46(1):136-7. No abstract available. PMID: 12643262 [PubMed - indexed for MEDLINE]Related articles

Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity.

Stumvoll M, Stefan N, Fritsche A, Madaus A, Tschritter O, Koch M, Machicao F, Häring H.

J Mol Med. 2002 Jan;80(1):33-8. Epub 2001 Sep 15.PMID: 11862322 [PubMed - indexed for MEDLINE]Related articles

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.

Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, Sampson MJ, Feskens EJ, Hattersley AT, McCarthy MI.

Diabetes. 2004 Dec;53(12):3319-22.PMID: 15561966 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes.

Stene LC, Thorsby PM, Berg JP, Rønningen KS, Joner G; Norwegian Childhood Diabetes Study Group.

Pediatr Diabetes. 2008 Feb;9(1):40-5.PMID: 18211635 [PubMed - indexed for MEDLINE]Related articles

A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians.

Muller YL, Bogardus C, Beamer BA, Shuldiner AR, Baier LJ.

Diabetes. 2003 Jul;52(7):1864-71.PMID: 12829658 [PubMed - indexed for MEDLINE]Related articlesFree article

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.

Florez JC, Sjögren M, Agapakis CM, Burtt NP, Almgren P, Lindblad U, Berglund G, Tuomi T, Gaudet D, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L.

Diabetologia. 2007 Jun;50(6):1209-17. Epub 2007 Apr 19.PMID: 17443311 [PubMed - indexed for MEDLINE]Related articles

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.

Andrulionyte L, Peltola P, Chiasson JL, Laakso M; STOP-NIDDM Study Group.

Diabetes. 2006 Jul;55(7):2148-52.PMID: 16804087 [PubMed - indexed for MEDLINE]Related articlesFree article

Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.

Florez JC, Sjögren M, Burtt N, Orho-Melander M, Schayer S, Sun M, Almgren P, Lindblad U, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L.

Diabetes. 2004 Dec;53(12):3313-8.PMID: 15561965 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S.

Diabetes. 2008 Mar;57(3):791-5. Epub 2007 Dec 27.PMID: 18162508 [PubMed - indexed for MEDLINE]Related articlesFree article

The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.

Douglas JA, Erdos MR, Watanabe RM, Braun A, Johnston CL, Oeth P, Mohlke KL, Valle TT, Ehnholm C, Buchanan TA, Bergman RN, Collins FS, Boehnke M, Tuomilehto J.

Diabetes. 2001 Apr;50(4):886-90.PMID: 11289057 [PubMed - indexed for MEDLINE]Related articlesFree article

Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.

Andrulionytè L, Zacharova J, Chiasson JL, Laakso M; STOP-NIDDM Study Group.

Diabetologia. 2004 Dec;47(12):2176-84. Epub 2004 Dec 8.PMID: 15592662 [PubMed - indexed for MEDLINE]Related articles

Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.

Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S.

Diabetes. 2006 Aug;55(8):2379-86.PMID: 16873704 [PubMed - indexed for MEDLINE]Related articlesFree article

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.

Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW, Clayton D, Schafer AJ, O'Rahilly S, Wareham NJ.

PLoS Biol. 2003 Oct;1(1):E20. Epub 2003 Oct 13. Erratum in: PLoS Biol. 2003 Dec;1(3):445. PMID: 14551916 [PubMed - indexed for MEDLINE]Related articlesFree article