PubMed

Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells.

Christen U, Darwiche R, Thomas HE, Wolfe T, Rodrigo E, Chervonsky A, Flavell RA, von Herrath MG.

Diabetes. 2004 Mar;53(3):591-6.PMID: 14988242 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM.

von Herrath M, Holz A.

J Autoimmun. 1997 Jun;10(3):231-8.PMID: 9218748 [PubMed - indexed for MEDLINE]Related articles

Neither B lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes.

Holz A, Dyrberg T, Hagopian W, Homann D, von Herrath M, Oldstone MB.

J Immunol. 2000 Nov 15;165(10):5945-53.PMID: 11067957 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity.

Kägi D, Odermatt B, Ohashi PS, Zinkernagel RM, Hengartner H.

J Exp Med. 1996 May 1;183(5):2143-52.PMID: 8642324 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection.

Zhou S, Ou R, Huang L, Moskophidis D.

J Virol. 2002 Jan;76(2):829-40.PMID: 11752172 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of antiviral CD8 lymphocytes in vivo with dendritic cells expressing Fas ligand-increased survival of viral (lymphocytic choriomeningitis virus) central nervous system infection.

Wolfe T, Asseman C, Hughes A, Matsue H, Takashima A, von Herrath MG.

J Immunol. 2002 Nov 1;169(9):4867-72.PMID: 12391197 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development.

Rhode A, Pauza ME, Barral AM, Rodrigo E, Oldstone MB, von Herrath MG, Christen U.

J Immunol. 2005 Sep 15;175(6):3516-24.PMID: 16148094 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration.

McKall-Faienza KJ, Kawai K, Kündig TM, Odermatt B, Bachmann MF, Zakarian A, Mak TW, Ohashi PS.

Int Immunol. 1998 Apr;10(4):405-12.PMID: 9620596 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of accelerated immune-mediated diabetes resulting from islet beta cell expression of a Fas ligand transgene.

Silva DG, Petrovsky N, Socha L, Slattery R, Gatenby P, Charlton B.

J Immunol. 2003 May 15;170(10):4996-5002.PMID: 12734343 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens.

Yamanouchi J, Verdaguer J, Han B, Amrani A, Serra P, Santamaria P.

J Immunol. 2003 Dec 15;171(12):6900-9.PMID: 14662897 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection from type 1 diabetes in the face of high levels of activated autoaggressive lymphocytes in a viral transgenic mouse model crossed to the SV129 strain.

von Herrath MG, Wolfe T, Möhrle U, Coon B, Hughes A.

Diabetes. 2001 Dec;50(12):2700-8.PMID: 11723052 [PubMed - indexed for MEDLINE]Related articlesFree article

[Viral antigen induced autoimmunity: an animal model for diabetes mellitus type I]

Hengartner H.

Verh Dtsch Ges Pathol. 1994;78:177-9. German. PMID: 7533982 [PubMed - indexed for MEDLINE]Related articles

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

Ohashi PS, Oehen S, Aichele P, Pircher H, Odermatt B, Herrera P, Higuchi Y, Buerki K, Hengartner H, Zinkernagel RM.

J Immunol. 1993 Jun 1;150(11):5185-94.PMID: 8496610 [PubMed - indexed for MEDLINE]Related articles

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.

J Autoimmun. 2006 Nov;27(3):166-73. Epub 2006 Oct 10.PMID: 17045460 [PubMed - indexed for MEDLINE]Related articles

Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity.

Garza KM, McKall-Faienza KJ, Otheki T, Zakarian A, Odermatt B, Ohashi PS.

Eur J Immunol. 2002 Mar;32(3):885-94.PMID: 11870633 [PubMed - indexed for MEDLINE]Related articles

Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus.

von Herrath MG, Oldstone MB.

J Exp Med. 1997 Feb 3;185(3):531-9.PMID: 9053453 [PubMed - indexed for MEDLINE]Related articlesFree article

Fas and Fas ligand immunolocalization in pancreatic islets of NOD mice during spontaneous and cyclophosphamide-accelerated diabetes.

Redd S, Ginn S, Ross JM.

Histochem J. 2002 Jan-Feb;34(1-2):1-12.PMID: 12365794 [PubMed - indexed for MEDLINE]Related articles

Bystander sensitization to activation-induced cell death as a mechanism of virus-induced immune suppression.

Zarozinski CC, McNally JM, Lohman BL, Daniels KA, Welsh RM.

J Virol. 2000 Apr;74(8):3650-8.PMID: 10729141 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.

Rode M, Balkow S, Sobek V, Brehm R, Martin P, Kersten A, Dumrese T, Stehle T, Müllbacher A, Wallich R, Simon MM.

J Virol. 2004 Nov;78(22):12395-405.PMID: 15507626 [PubMed - indexed for MEDLINE]Related articlesFree article

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.

von Herrath MG, Allison J, Miller JF, Oldstone MB.

J Clin Invest. 1995 Feb;95(2):477-85.PMID: 7860729 [PubMed - indexed for MEDLINE]Related articlesFree article