My NCBI | Sign In
RSS Settings
  • Search:

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

    Results: 1 to 20 of 281

    1.

    Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.

    Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L.

    Diabetes. 2004 Mar;53(3):535-41.PMID: 14988235 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

    Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

    J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The physiological role of glucokinase binding and translocation in hepatocytes.

    Agius L.

    Adv Enzyme Regul. 1998;38:303-31.PMID: 9762360 [PubMed - indexed for MEDLINE]Related articles

    4.

    The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.

    de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L.

    J Biol Chem. 2000 Apr 7;275(14):10597-603.PMID: 10744755 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase.

    Aiston S, Trinh KY, Lange AJ, Newgard CB, Agius L.

    J Biol Chem. 1999 Aug 27;274(35):24559-66.PMID: 10455119 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.

    Farrelly D, Brown KS, Tieman A, Ren J, Lira SA, Hagan D, Gregg R, Mookhtiar KA, Hariharan N.

    Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14511-6.PMID: 10588736 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

    Mukhtar MH, Payne VA, Arden C, Harbottle A, Khan S, Lange AJ, Agius L.

    Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R766-74. Epub 2008 Jan 16.PMID: 18199594 [PubMed - indexed for MEDLINE]Related articles

    8.

    Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.

    de la Iglesia N, Veiga-da-Cunha M, Van Schaftingen E, Guinovart JJ, Ferrer JC.

    FEBS Lett. 1999 Aug 6;456(2):332-8.PMID: 10456334 [PubMed - indexed for MEDLINE]Related articles

    9.

    Control of glucokinase translocation in rat hepatocytes by sorbitol and the cytosolic redox state.

    Agius L.

    Biochem J. 1994 Feb 15;298 ( Pt 1):237-43.PMID: 8129726 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Allosteric activators of glucokinase: potential role in diabetes therapy.

    Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.

    Science. 2003 Jul 18;301(5631):370-3.PMID: 12869762 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Shuttling of glucokinase between the nucleus and the cytoplasm in primary cultures of rat hepatocytes: possible involvement in the regulation of the glucose metabolism.

    Toyoda Y, Ito Y, Yoshie S, Miwa I.

    Arch Histol Cytol. 1997 Aug;60(3):307-16.PMID: 9376178 [PubMed - indexed for MEDLINE]Related articles

    12.

    Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.

    Heredia VV, Carlson TJ, Garcia E, Sun S.

    J Biol Chem. 2006 Dec 29;281(52):40201-7. Epub 2006 Nov 2.PMID: 17082186 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.

    Anderka O, Boyken J, Aschenbach U, Batzer A, Boscheinen O, Schmoll D.

    J Biol Chem. 2008 Nov 14;283(46):31333-40. Epub 2008 Sep 22.PMID: 18809676 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver.

    Hiskett EK, Suwitheechon OU, Lindbloom-Hawley S, Boyle DL, Schermerhorn T.

    Vet Res Commun. 2009 Mar;33(3):227-40. Epub 2008 Sep 9.PMID: 18780155 [PubMed - indexed for MEDLINE]Related articles

    15.

    Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites.

    Agius L, Stubbs M.

    Biochem J. 2000 Mar 1;346 Pt 2:413-21.PMID: 10677361 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats.

    Fujimoto Y, Torres TP, Donahue EP, Shiota M.

    Diabetes. 2006 Sep;55(9):2479-90.PMID: 16936196 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Activation and translocation of glucokinase in rat primary hepatocytes monitored by high content image analysis.

    Wolff M, Kauschke SG, Schmidt S, Heilker R.

    J Biomol Screen. 2008 Oct;13(9):837-46. Epub 2008 Sep 23.PMID: 18812575 [PubMed - indexed for MEDLINE]Related articles

    18.

    Glucose modulation of glucokinase activation by small molecules.

    Ralph EC, Thomson J, Almaden J, Sun S.

    Biochemistry. 2008 Apr 29;47(17):5028-36. Epub 2008 Mar 28.PMID: 18370405 [PubMed - indexed for MEDLINE]Related articles

    19.

    Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.

    Slosberg ED, Desai UJ, Fanelli B, St Denny I, Connelly S, Kaleko M, Boettcher BR, Caplan SL.

    Diabetes. 2001 Aug;50(8):1813-20.PMID: 11473043 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.

    Shin JS, Torres TP, Catlin RL, Donahue EP, Shiota M.

    Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1381-90. Epub 2007 Jan 4.PMID: 17204595 [PubMed - indexed for MEDLINE]Related articles

    Display Settings:

    Format
    Items per page
    Sort by

    Send to:

    Choose Destination

    Supplemental Content

    Filter your results:

    Find related data

    Recent activity