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    Results: 1 to 20 of 152

    1.

    Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells.

    Bao S, Jin C, Zhang S, Turk J, Ma Z, Ramanadham S.

    Diabetes. 2004 Feb;53 Suppl 1:S186-9.PMID: 14749286 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.

    Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Song H, Bao S, Ma Z, Turk J.

    Biochemistry. 2004 Feb 3;43(4):918-30.PMID: 14744135 [PubMed - indexed for MEDLINE]Related articles

    3.

    Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.

    Ramanadham S, Song H, Hsu FF, Zhang S, Crankshaw M, Grant GA, Newgard CB, Bao S, Ma Z, Turk J.

    Biochemistry. 2003 Dec 2;42(47):13929-40.PMID: 14636061 [PubMed - indexed for MEDLINE]Related articles

    4.

    Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.

    Ma Z, Ramanadham S, Wohltmann M, Bohrer A, Hsu FF, Turk J.

    J Biol Chem. 2001 Apr 20;276(16):13198-208. Epub 2001 Jan 22.PMID: 11278673 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.

    Ma Z, Zhang S, Turk J, Ramanadham S.

    Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E820-33.PMID: 11882502 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.

    Wang Z, Ramanadham S, Ma ZA, Bao S, Mancuso DJ, Gross RW, Turk J.

    J Biol Chem. 2005 Feb 25;280(8):6840-9. Epub 2004 Dec 2.PMID: 15576376 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

    Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

    Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.

    Lei X, Zhang S, Bohrer A, Ramanadham S.

    J Biol Chem. 2008 Dec 12;283(50):34819-32. Epub 2008 Oct 20.PMID: 18936091 [PubMed - indexed for MEDLINE]Related articles

    9.

    Islet complex lipids: involvement in the actions of group VIA calcium-independent phospholipase A(2) in beta-cells.

    Ramanadham S, Song H, Bao S, Hsu FF, Zhang S, Ma Z, Jin C, Turk J.

    Diabetes. 2004 Feb;53 Suppl 1:S179-85. Review.PMID: 14749285 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes.

    Ramanadham S, Bohrer A, Gross RW, Turk J.

    Biochemistry. 1993 Dec 14;32(49):13499-509.PMID: 8257685 [PubMed - indexed for MEDLINE]Related articles

    11.

    Cloning and expression of a group IV cytosolic Ca2+-dependent phospholipase A2 from rat pancreatic islets. Comparison of the expressed activity with that of an islet group VI cytosolic Ca2+-independent phospholipase A2.

    Ma Z, Ramanadham S, Hu Z, Turk J.

    Biochim Biophys Acta. 1998 Apr 22;1391(3):384-400.PMID: 9555100 [PubMed - indexed for MEDLINE]Related articles

    12.

    Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.

    Bao S, Song H, Wohltmann M, Ramanadham S, Jin W, Bohrer A, Turk J.

    J Biol Chem. 2006 Jul 28;281(30):20958-73. Epub 2006 May 27.PMID: 16732058 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs.

    Shirai Y, Balsinde J, Dennis EA.

    Biochim Biophys Acta. 2005 Jul 15;1735(2):119-29.PMID: 15967714 [PubMed - indexed for MEDLINE]Related articles

    14.

    The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.

    Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S.

    Biochemistry. 2007 Sep 4;46(35):10170-85. Epub 2007 Aug 9.PMID: 17685585 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells.

    Ramanadham S, Hsu FF, Bohrer A, Ma Z, Turk J.

    J Biol Chem. 1999 May 14;274(20):13915-27.PMID: 10318801 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells.

    Gross RW, Ramanadham S, Kruszka KK, Han X, Turk J.

    Biochemistry. 1993 Jan 12;32(1):327-36.PMID: 8418853 [PubMed - indexed for MEDLINE]Related articles

    17.

    Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species.

    Ramanadham S, Bohrer A, Mueller M, Jett P, Gross RW, Turk J.

    Biochemistry. 1993 May 25;32(20):5339-51.PMID: 8499439 [PubMed - indexed for MEDLINE]Related articles

    18.

    Glucose-responsitivity and expression of an ATP-stimulatable, Ca(2+)-independent phospholipase A2 enzyme in clonal insulinoma cell lines.

    Ramanadham S, Wolf MJ, Li B, Bohrer A, Turk J.

    Biochim Biophys Acta. 1997 Jan 21;1344(2):153-64.PMID: 9030192 [PubMed - indexed for MEDLINE]Related articles

    19.

    Effects of biological oxidants on the catalytic activity and structure of group VIA phospholipase A2.

    Song H, Bao S, Ramanadham S, Turk J.

    Biochemistry. 2006 May 23;45(20):6392-406.PMID: 16700550 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance.

    Song K, Zhang X, Zhao C, Ang NT, Ma ZA.

    Mol Endocrinol. 2005 Feb;19(2):504-15. Epub 2004 Oct 7.PMID: 15471944 [PubMed - indexed for MEDLINE]Related articlesFree article

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