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Islet complex lipids: involvement in the actions of group VIA calcium-independent phospholipase A(2) in beta-cells.
Ramanadham S, Song H, Bao S, Hsu FF, Zhang S, Ma Z, Jin C, Turk J.
Diabetes. 2004 Feb;53 Suppl 1:S179-85. Review.PMID: 14749285 [PubMed - indexed for MEDLINE]Related articlesFree article
Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.
Ramanadham S, Song H, Hsu FF, Zhang S, Crankshaw M, Grant GA, Newgard CB, Bao S, Ma Z, Turk J.
Biochemistry. 2003 Dec 2;42(47):13929-40.PMID: 14636061 [PubMed - indexed for MEDLINE]Related articles
The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells.
Turk J, Ramanadham S.
Can J Physiol Pharmacol. 2004 Oct;82(10):824-32. Review.PMID: 15573142 [PubMed - indexed for MEDLINE]Related articles
Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
Wang Z, Ramanadham S, Ma ZA, Bao S, Mancuso DJ, Gross RW, Turk J.
J Biol Chem. 2005 Feb 25;280(8):6840-9. Epub 2004 Dec 2.PMID: 15576376 [PubMed - indexed for MEDLINE]Related articlesFree article
Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells.
Bao S, Jin C, Zhang S, Turk J, Ma Z, Ramanadham S.
Diabetes. 2004 Feb;53 Suppl 1:S186-9.PMID: 14749286 [PubMed - indexed for MEDLINE]Related articlesFree article
Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.
Ma Z, Ramanadham S, Wohltmann M, Bohrer A, Hsu FF, Turk J.
J Biol Chem. 2001 Apr 20;276(16):13198-208. Epub 2001 Jan 22.PMID: 11278673 [PubMed - indexed for MEDLINE]Related articlesFree article
Effects of biological oxidants on the catalytic activity and structure of group VIA phospholipase A2.
Song H, Bao S, Ramanadham S, Turk J.
Biochemistry. 2006 May 23;45(20):6392-406.PMID: 16700550 [PubMed - indexed for MEDLINE]Related articlesFree article
Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.
Bao S, Song H, Wohltmann M, Ramanadham S, Jin W, Bohrer A, Turk J.
J Biol Chem. 2006 Jul 28;281(30):20958-73. Epub 2006 May 27.PMID: 16732058 [PubMed - indexed for MEDLINE]Related articlesFree article
Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Song H, Bao S, Ma Z, Turk J.
Biochemistry. 2004 Feb 3;43(4):918-30.PMID: 14744135 [PubMed - indexed for MEDLINE]Related articles
Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells.
Ramanadham S, Hsu FF, Bohrer A, Ma Z, Turk J.
J Biol Chem. 1999 May 14;274(20):13915-27.PMID: 10318801 [PubMed - indexed for MEDLINE]Related articlesFree article
Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.
Bao S, Miller DJ, Ma Z, Wohltmann M, Eng G, Ramanadham S, Moley K, Turk J.
J Biol Chem. 2004 Sep 10;279(37):38194-200. Epub 2004 Jul 12.PMID: 15252026 [PubMed - indexed for MEDLINE]Related articlesFree article
Glucose-responsitivity and expression of an ATP-stimulatable, Ca(2+)-independent phospholipase A2 enzyme in clonal insulinoma cell lines.
Ramanadham S, Wolf MJ, Li B, Bohrer A, Turk J.
Biochim Biophys Acta. 1997 Jan 21;1344(2):153-64.PMID: 9030192 [PubMed - indexed for MEDLINE]Related articles
Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells.
Gross RW, Ramanadham S, Kruszka KK, Han X, Turk J.
Biochemistry. 1993 Jan 12;32(1):327-36.PMID: 8418853 [PubMed - indexed for MEDLINE]Related articles
Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensor.
Ramanadham S, Wolf MJ, Jett PA, Gross RW, Turk J.
Biochemistry. 1994 Jun 14;33(23):7442-52.PMID: 8003509 [PubMed - indexed for MEDLINE]Related articles
Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin.
Ma Z, Ramanadham S, Kempe K, Chi XS, Ladenson J, Turk J.
J Biol Chem. 1997 Apr 25;272(17):11118-27.PMID: 9111008 [PubMed - indexed for MEDLINE]Related articlesFree article
Membrane phospholipid turnover as an intermediary step in insulin secretion. Putative roles of phospholipases in cell signaling.
Metz SA.
Am J Med. 1988 Nov 28;85(5A):9-21. Review.PMID: 3057898 [PubMed - indexed for MEDLINE]Related articles
Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity.
Manguikian AD, Barbour SE.
J Biol Chem. 2004 Dec 17;279(51):52881-92. Epub 2004 Sep 22.PMID: 15385540 [PubMed - indexed for MEDLINE]Related articlesFree article
Evidence for association of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from pancreatic islets and HIT insulinoma cells with a phosphofructokinase-like protein.
Ramanadham S, Wolf MJ, Ma Z, Li B, Wang J, Gross RW, Turk J.
Biochemistry. 1996 Apr 30;35(17):5464-71.PMID: 8611537 [PubMed - indexed for MEDLINE]Related articles
Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.
Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J.
J Biol Chem. 2007 Sep 14;282(37):27100-14. Epub 2007 Jul 12.PMID: 17627946 [PubMed - indexed for MEDLINE]Related articlesFree article
Phospholipase A2 activity in pancreatic islets is calcium-dependent and stimulated by glucose.
Laychock SG.
Cell Calcium. 1982 Mar;3(1):43-54.PMID: 7049396 [PubMed - indexed for MEDLINE]Related articles
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