PubMed

Leptin effects on pancreatic beta-cell gene expression and function.

Seufert J.

Diabetes. 2004 Feb;53 Suppl 1:S152-8. Review.PMID: 14749281 [PubMed - indexed for MEDLINE]Related articlesFree article

The adipoinsular axis: effects of leptin on pancreatic beta-cells.

Kieffer TJ, Habener JF.

Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E1-E14. Review.PMID: 10644531 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.

Matias I, Gonthier MP, Orlando P, Martiadis V, De Petrocellis L, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R, Roche R, Maj M, Pagotto U, Monteleone P, Di Marzo V.

J Clin Endocrinol Metab. 2006 Aug;91(8):3171-80. Epub 2006 May 9.PMID: 16684820 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.

Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF.

J Clin Endocrinol Metab. 1999 Feb;84(2):670-6.PMID: 10022436 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells.

Laubner K, Kieffer TJ, Lam NT, Niu X, Jakob F, Seufert J.

Diabetes. 2005 Dec;54(12):3410-7.PMID: 16306356 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin inhibition of insulin secretion from isolated human islets.

Fehmann HC, Berghöfer P, Brandhorst D, Brandhorst H, Hering B, Bretzel RG, Göke B.

Acta Diabetol. 1997 Dec;34(4):249-52.PMID: 9451467 [PubMed - indexed for MEDLINE]Related articles

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.

Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN.

J Clin Invest. 2007 Oct;117(10):2860-8.PMID: 17909627 [PubMed - indexed for MEDLINE]Related articlesFree article

The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis.

Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ.

Cell Metab. 2006 Oct;4(4):291-302.PMID: 17011502 [PubMed - indexed for MEDLINE]Related articles

Does leptin regulate insulin secretion?

Poitout V, Rouault C, Guerre-Millo M, Reach G.

Diabetes Metab. 1998 Sep;24(4):321-6. Review.PMID: 9805642 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin: a potent inhibitor of insulin secretion.

Fehmann HC, Peiser C, Bode HP, Stamm M, Staats P, Hedetoft C, Lang RE, Göke B.

Peptides. 1997;18(8):1267-73.PMID: 9396072 [PubMed - indexed for MEDLINE]Related articles

Rethinking leptin and insulin action: therapeutic opportunities for diabetes.

Yildiz BO, Haznedaroglu IC.

Int J Biochem Cell Biol. 2006;38(5-6):820-30. Epub 2005 Oct 3. Review.PMID: 16236542 [PubMed - indexed for MEDLINE]Related articles

Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line.

Kawamura Y, Tanaka Y, Kawamori R, Maeda S.

Mol Endocrinol. 2006 Apr;20(4):844-56. Epub 2005 Dec 8.PMID: 16339272 [PubMed - indexed for MEDLINE]Related articlesFree article

[And what about diabetes?]

Cerasi E.

Bull Acad Natl Med. 2007 Apr-May;191(4-5):941-3; discussion 943. French. PMID: 18225448 [PubMed - indexed for MEDLINE]Related articles

Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling.

Park S, Hong SM, Sung SR, Jung HK.

Endocrinology. 2008 Feb;149(2):445-54. Epub 2007 Nov 8.PMID: 17991727 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.PMID: 14871885 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.

Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R.

FASEB J. 2008 Jun;22(6):1905-13. Epub 2008 Feb 8.PMID: 18263705 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin signaling in the central nervous system and the periphery.

Bjørbaek C, Kahn BB.

Recent Prog Horm Res. 2004;59:305-31. Review.PMID: 14749508 [PubMed - indexed for MEDLINE]Related articlesFree article

TNFalpha and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells.

Tsiotra PC, Tsigos C, Raptis SA.

Int J Obes Relat Metab Disord. 2001 Jul;25(7):1018-26.PMID: 11443501 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.PMID: 15141093 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of paradoxical observations on the association between leptin and insulin resistance.

Ceddia RB, Koistinen HA, Zierath JR, Sweeney G.

FASEB J. 2002 Aug;16(10):1163-76. Review.PMID: 12153984 [PubMed - indexed for MEDLINE]Related articlesFree article