PubMed

Uncoupling protein 2 and islet function.

Chan CB, Saleh MC, Koshkin V, Wheeler MB.

Diabetes. 2004 Feb;53 Suppl 1:S136-42. Review.PMID: 14749279 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous regulation of insulin secretion by UCP2.

Chan CB.

Clin Lab. 2002;48(11-12):599-604. Review.PMID: 12465744 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin secretion by uncoupling protein.

Chan CB, Kashemsant N.

Biochem Soc Trans. 2006 Nov;34(Pt 5):802-5.PMID: 17052202 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB.

Cell. 2001 Jun 15;105(6):745-55.PMID: 11440717 [PubMed - indexed for MEDLINE]Related articles

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB.

J Clin Invest. 2003 Dec;112(12):1831-42.PMID: 14679178 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.

Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB.

Diabetes. 2002 Nov;51(11):3211-9.PMID: 12401712 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.PMID: 17131143 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

The mitochondrial uncoupling-protein homologues.

Krauss S, Zhang CY, Lowell BB.

Nat Rev Mol Cell Biol. 2005 Mar;6(3):248-61. Review.PMID: 15738989 [PubMed - indexed for MEDLINE]Related articles

The emerging functions of UCP2 in health, disease, and therapeutics.

Mattiasson G, Sullivan PG.

Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):1-38. Review.PMID: 16487034 [PubMed - indexed for MEDLINE]Related articles

The role of uncoupling protein 2 in the development of type 2 diabetes.

Langin D.

Drugs Today (Barc). 2003 Apr;39(4):287-95. Review.PMID: 12743644 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice.

Chu KY, Leung PS.

Antioxid Redox Signal. 2007 Jul;9(7):869-78.PMID: 17508912 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin.

Lee SC, Robson-Doucette CA, Wheeler MB.

J Endocrinol. 2009 Oct;203(1):33-43. Epub 2009 Jul 27.PMID: 19635759 [PubMed - indexed for MEDLINE]Related articles

Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.

Medvedev AV, Robidoux J, Bai X, Cao W, Floering LM, Daniel KW, Collins S.

J Biol Chem. 2002 Nov 8;277(45):42639-44. Epub 2002 Aug 29.PMID: 12205102 [PubMed - indexed for MEDLINE]Related articlesFree article

Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats.

Kassis N, Bernard C, Pusterla A, Casteilla L, Pénicaud L, Richard D, Ricquier D, Ktorza A.

Int J Exp Diabetes Res. 2000;1(3):185-93.PMID: 11467409 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action.

De Souza CT, Araújo EP, Stoppiglia LF, Pauli JR, Ropelle E, Rocco SA, Marin RM, Franchini KG, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

FASEB J. 2007 Apr;21(4):1153-63. Epub 2007 Jan 5.PMID: 17209127 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

Chan CB, MacDonald PE, Saleh MC, Johns DC, Marbàn E, Wheeler MB.

Diabetes. 1999 Jul;48(7):1482-6.PMID: 10389858 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.

Emre Y, Hurtaud C, Karaca M, Nubel T, Zavala F, Ricquier D.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19085-90. Epub 2007 Nov 15.PMID: 18006654 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells.

Oberkofler H, Klein K, Felder TK, Krempler F, Patsch W.

Endocrinology. 2006 Feb;147(2):966-76. Epub 2005 Nov 10.PMID: 16282353 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article