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    Results: 1 to 20 of 131

    1.

    Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion.

    Sugden MC, Holness MJ.

    Diabetes. 2004 Feb;53 Suppl 1:S71-81. Review.PMID: 14749269 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.

    Sugden MC, Bulmer K, Augustine D, Holness MJ.

    Diabetes. 2001 Dec;50(12):2729-36.PMID: 11723055 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance.

    Sugden MC, Holness MJ.

    Biochem Soc Trans. 2008 Oct;36(Pt 5):891-900. Review.PMID: 18793157 [PubMed - indexed for MEDLINE]Related articles

    4.

    PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance.

    Guerre-Millo M, Rouault C, Poulain P, André J, Poitout V, Peters JM, Gonzalez FJ, Fruchart JC, Reach G, Staels B.

    Diabetes. 2001 Dec;50(12):2809-14.PMID: 11723064 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

    Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S.

    Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. Epub 2003 Nov 18.PMID: 14625208 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.

    Holness MJ, Smith ND, Greenwood GK, Sugden MC.

    J Endocrinol. 2003 May;177(2):197-205.PMID: 12740007 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness.

    Sugden MC, Greenwood GK, Smith ND, Holness MJ.

    Endocrinology. 2003 Jan;144(1):146-53.PMID: 12488340 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism.

    Bergeron R, Yao J, Woods JW, Zycband EI, Liu C, Li Z, Adams A, Berger JP, Zhang BB, Moller DE, Doebber TW.

    Endocrinology. 2006 Sep;147(9):4252-62. Epub 2006 May 25.PMID: 16728496 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.

    Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM.

    Diabetes. 2002 Sep;51(9):2749-56.PMID: 12196468 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells.

    Kim HI, Ahn YH.

    Diabetes. 2004 Feb;53 Suppl 1:S60-5. Review.PMID: 14749267 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha).

    Bihan H, Rouault C, Reach G, Poitout V, Staels B, Guerre-Millo M.

    FEBS Lett. 2005 Apr 25;579(11):2284-8.PMID: 15848159 [PubMed - indexed for MEDLINE]Related articles

    12.

    Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy.

    Holness MJ, Greenwood GK, Smith ND, Sugden MC.

    Diabetes. 2006 Dec;55(12):3501-8.PMID: 17130498 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox.

    Yoshikawa H, Tajiri Y, Sako Y, Hashimoto T, Umeda F, Nawata H.

    Metabolism. 2001 May;50(5):613-8.PMID: 11319727 [PubMed - indexed for MEDLINE]Related articles

    14.

    The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.

    Ferré P.

    Diabetes. 2004 Feb;53 Suppl 1:S43-50. Review.PMID: 14749265 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.

    Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T.

    Diabetes. 2004 Nov;53(11):2844-54.PMID: 15504964 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.

    Holness MJ, Greenwood GK, Smith ND, Sugden MC.

    Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1380-9. Epub 2008 Oct 14.PMID: 18854422 [PubMed - indexed for MEDLINE]Related articles

    17.

    Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.

    Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM.

    Mol Cell Biol. 2003 Oct;23(20):7222-9.PMID: 14517292 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Diabetogenic impact of long-chain omega-3 fatty acids on pancreatic beta-cell function and the regulation of endogenous glucose production.

    Holness MJ, Greenwood GK, Smith ND, Sugden MC.

    Endocrinology. 2003 Sep;144(9):3958-68.PMID: 12933670 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

    Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S.

    Endocrinology. 2005 Aug;146(8):3266-76. Epub 2005 May 5.PMID: 15878969 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

    Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart JC, Kuipers F, Pattou F, Fiévet C, Staels B.

    Diabetes. 2006 Jun;55(6):1605-13.PMID: 16731822 [PubMed - indexed for MEDLINE]Related articlesFree article

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