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    Results: 1 to 20 of 383

    1.

    Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.

    Davani B, Portwood N, Bryzgalova G, Reimer MK, Heiden T, Ostenson CG, Okret S, Ahren B, Efendic S, Khan A.

    Diabetes. 2004 Feb;53 Suppl 1:S51-9.PMID: 14749266 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Chronic sympathetic innervation of islets in transgenic mice results in differential desensitization of alpha-adrenergic inhibition of insulin secretion.

    Grodsky GM, Ma YH, Edwards RH.

    Adv Exp Med Biol. 1997;426:129-38.PMID: 9544265 [PubMed - indexed for MEDLINE]Related articles

    3.

    Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.

    Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.

    Mol Med. 1999 Mar;5(3):169-80.PMID: 10404514 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.

    Delaunay F, Khan A, Cintra A, Davani B, Ling ZC, Andersson A, Ostenson CG, Gustafsson J, Efendic S, Okret S.

    J Clin Invest. 1997 Oct 15;100(8):2094-8.PMID: 9329975 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

    Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

    J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis.

    Devedjian JC, Pujol A, Cayla C, George M, Casellas A, Paris H, Bosch F.

    Diabetologia. 2000 Jul;43(7):899-906.PMID: 10952463 [PubMed - indexed for MEDLINE]Related articles

    7.

    Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release.

    Ling ZC, Khan A, Delauny F, Davani B, Ostenson CG, Gustafsson JA, Okret S, Landau BR, Efendic S.

    Diabetologia. 1998 Jun;41(6):634-9.PMID: 9662043 [PubMed - indexed for MEDLINE]Related articles

    8.

    Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

    Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

    Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    A defective stimulus-secretion coupling rather than glucotoxicity mediates the impaired insulin secretion in the mildly diabetic F1 hybrids of GK-Wistar rats.

    Abdel-Halim SM, Ostenson CG, Andersson A, Jansson L, Efendić S.

    Diabetes. 1995 Nov;44(11):1280-4.PMID: 7589824 [PubMed - indexed for MEDLINE]Related articles

    10.

    Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.

    Kobayashi M, Ohnishi H, Okazawa H, Murata Y, Hayashi Y, Kobayashi H, Kitamura T, Matozaki T.

    Endocrinology. 2008 Nov;149(11):5662-9. Epub 2008 Jul 17.PMID: 18635660 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretion.

    Ma YH, Landis C, Tchao N, Wang J, Rodd G, Hanahan D, Bourne HR, Grodsky GM.

    Endocrinology. 1994 Jan;134(1):42-7.PMID: 7506212 [PubMed - indexed for MEDLINE]Related articles

    12.

    beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

    Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo.

    Kato I, Suzuki Y, Akabane A, Yonekura H, Tanaka O, Kondo H, Takasawa S, Yoshimoto T, Okamoto H.

    J Biol Chem. 1994 Aug 19;269(33):21223-8.PMID: 8063743 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.

    Herbach N, Goeke B, Schneider M, Hermanns W, Wolf E, Wanke R.

    Regul Pept. 2005 Feb 15;125(1-3):103-17.PMID: 15582721 [PubMed - indexed for MEDLINE]Related articles

    15.

    Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.

    Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, Ullrich S.

    Eur J Endocrinol. 2003 Oct;149(4):343-50.PMID: 14514350 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.

    Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS.

    Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51.PMID: 10662719 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

    Jackerott M, Møldrup A, Thams P, Galsgaard ED, Knudsen J, Lee YC, Nielsen JH.

    Diabetes. 2006 Oct;55(10):2705-12.PMID: 17003334 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion.

    Horio F, Teradaira S, Imamura T, Anunciado RV, Kobayashi M, Namikawa T, Niki I.

    Eur J Endocrinol. 2005 Dec;153(6):971-9.PMID: 16322404 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

    Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, Stewart AF.

    J Biol Chem. 2000 May 19;275(20):15399-406.PMID: 10809775 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

    Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S.

    Diabetes. 2002 Jun;51(6):1793-804.PMID: 12031967 [PubMed - indexed for MEDLINE]Related articlesFree article

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