PubMed

Putative metabolic effects of the liver X receptor (LXR).

Steffensen KR, Gustafsson JA.

Diabetes. 2004 Feb;53 Suppl 1:S36-42. Review.PMID: 14749264 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P.

Mol Pharmacol. 2006 Oct;70(4):1340-9. Epub 2006 Jul 6.PMID: 16825483 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissection of the insulin-sensitizing effect of liver X receptor ligands.

Commerford SR, Vargas L, Dorfman SE, Mitro N, Rocheford EC, Mak PA, Li X, Kennedy P, Mullarkey TL, Saez E.

Mol Endocrinol. 2007 Dec;21(12):3002-12. Epub 2007 Aug 23.PMID: 17717069 [PubMed - indexed for MEDLINE]Related articlesFree article

Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.

Lund EG, Peterson LB, Adams AD, Lam MH, Burton CA, Chin J, Guo Q, Huang S, Latham M, Lopez JC, Menke JG, Milot DP, Mitnaul LJ, Rex-Rabe SE, Rosa RL, Tian JY, Wright SD, Sparrow CP.

Biochem Pharmacol. 2006 Feb 14;71(4):453-63. Epub 2005 Dec 2.PMID: 16325781 [PubMed - indexed for MEDLINE]Related articles

Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals.

Steffensen KR, Neo SY, Stulnig TM, Vega VB, Rahman SS, Schuster GU, Gustafsson JA, Liu ET.

J Mol Endocrinol. 2004 Dec;33(3):609-22.PMID: 15591022 [PubMed - indexed for MEDLINE]Related articlesFree article

Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice.

Oosterveer MH, van Dijk TH, Grefhorst A, Bloks VW, Havinga R, Kuipers F, Reijngoud DJ.

J Biol Chem. 2008 Sep 12;283(37):25437-45. Epub 2008 Jul 8.PMID: 18611859 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological role of liver X receptors.

Baranowski M.

J Physiol Pharmacol. 2008 Dec;59 Suppl 7:31-55. Review.PMID: 19258656 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression.

Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ, Ham J, Kang H, Park MG, Steffensen KR, Stulnig TM, Gustafsson JA, Park SD, Kim JB.

Mol Cell Biol. 2004 Apr;24(8):3430-44.PMID: 15060163 [PubMed - indexed for MEDLINE]Related articlesFree article

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.

Cha JY, Repa JJ.

J Biol Chem. 2007 Jan 5;282(1):743-51. Epub 2006 Nov 14.PMID: 17107947 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility.

Volle DH, Mouzat K, Duggavathi R, Siddeek B, Déchelotte P, Sion B, Veyssière G, Benahmed M, Lobaccaro JM.

Mol Endocrinol. 2007 May;21(5):1014-27. Epub 2007 Mar 6.PMID: 17341595 [PubMed - indexed for MEDLINE]Related articlesFree article

Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.

Colin S, Bourguignon E, Boullay AB, Tousaint JJ, Huet S, Caira F, Staels B, Lestavel S, Lobaccaro JM, Delerive P.

Endocrinology. 2008 Oct;149(10):5128-35. Epub 2008 Jun 19.PMID: 18566121 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor is a therapeutic target for photoaging and chronological skin aging.

Chang KC, Shen Q, Oh IG, Jelinsky SA, Jenkins SF, Wang W, Wang Y, LaCava M, Yudt MR, Thompson CC, Freedman LP, Chung JH, Nagpal S.

Mol Endocrinol. 2008 Nov;22(11):2407-19. Epub 2008 Sep 11.PMID: 18787039 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.

Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W.

Gastroenterology. 2008 Feb;134(2):556-67. Epub 2007 Nov 28.PMID: 18242221 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively.

Steffensen KR, Nilsson M, Schuster GU, Stulnig TM, Dahlman-Wright K, Gustafsson JA.

Biochem Biophys Res Commun. 2003 Oct 17;310(2):589-93.PMID: 14521951 [PubMed - indexed for MEDLINE]Related articles

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.

Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5419-24. Epub 2003 Apr 15.PMID: 12697904 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target.

Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P.

J Lipid Res. 2004 Apr;45(4):616-25. Epub 2004 Jan 1.PMID: 14703507 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).

Wada T, Kang HS, Angers M, Gong H, Bhatia S, Khadem S, Ren S, Ellis E, Strom SC, Jetten AM, Xie W.

Mol Pharmacol. 2008 Mar;73(3):891-9. Epub 2007 Nov 30.PMID: 18055760 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue.

Stulnig TM, Steffensen KR, Gao H, Reimers M, Dahlman-Wright K, Schuster GU, Gustafsson JA.

Mol Pharmacol. 2002 Dec;62(6):1299-305.PMID: 12435796 [PubMed - indexed for MEDLINE]Related articlesFree article

LXR is crucial in lipid metabolism.

Ulven SM, Dalen KT, Gustafsson JA, Nebb HI.

Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):59-63. Review.PMID: 15913974 [PubMed - indexed for MEDLINE]Related articles

Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors.

Muscat GE, Wagner BL, Hou J, Tangirala RK, Bischoff ED, Rohde P, Petrowski M, Li J, Shao G, Macondray G, Schulman IG.

J Biol Chem. 2002 Oct 25;277(43):40722-8. Epub 2002 Aug 21.PMID: 12193599 [PubMed - indexed for MEDLINE]Related articlesFree article