PubMed

Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay.

Harries LW, Hattersley AT, Ellard S.

Diabetes. 2004 Feb;53(2):500-4.PMID: 14747304 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young.

Bulman MP, Harries LW, Hansen T, Shepherd M, Kelly WF, Hattersley AT, Ellard S.

Diabetologia. 2002 Oct;45(10):1463-7. Epub 2002 Sep 11.PMID: 12378390 [PubMed - indexed for MEDLINE]Related articles

Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.

Kaisaki PJ, Menzel S, Lindner T, Oda N, Rjasanowski I, Sahm J, Meincke G, Schulze J, Schmechel H, Petzold C, Ledermann HM, Sachse G, Boriraj VV, Menzel R, Kerner W, Turner RC, Yamagata K, Bell GI.

Diabetes. 1997 Mar;46(3):528-35. Erratum in: Diabetes 1997 Jul;46(7):1239. PMID: 9032114 [PubMed - indexed for MEDLINE]Related articles

The position of premature termination codons in the hepatocyte nuclear factor -1 beta gene determines susceptibility to nonsense-mediated decay.

Harries LW, Bingham C, Bellanne-Chantelot C, Hattersley AT, Ellard S.

Hum Genet. 2005 Nov;118(2):214-24. Epub 2005 Nov 15.PMID: 16133182 [PubMed - indexed for MEDLINE]Related articles

Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations.

Thomas H, Badenberg B, Bulman M, Lemm I, Lausen J, Kind L, Roosen S, Ellard S, Hattersley AT, Ryffel GU.

Biol Chem. 2002 Nov;383(11):1691-700.PMID: 12530534 [PubMed - indexed for MEDLINE]Related articles

Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative.

Yamagata K, Yang Q, Yamamoto K, Iwahashi H, Miyagawa J, Okita K, Yoshiuchi I, Miyazaki J, Noguchi T, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y.

Diabetes. 1998 Aug;47(8):1231-5.PMID: 9703322 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the hepatocyte nuclear factor-1alpha gene in Chinese MODY families: prevalence and functional analysis.

Xu JY, Chan V, Zhang WY, Wat NM, Lam KS.

Diabetologia. 2002 May;45(5):744-6. Epub 2002 Apr 3.PMID: 12107757 [PubMed - indexed for MEDLINE]Related articles

Abnormal splicing of hepatocyte nuclear factor-1 beta in the renal cysts and diabetes syndrome.

Harries LW, Ellard S, Jones RW, Hattersley AT, Bingham C.

Diabetologia. 2004 May;47(5):937-42. Epub 2004 Apr 15.PMID: 15085338 [PubMed - indexed for MEDLINE]Related articles

The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons.

Perrin-Vidoz L, Sinilnikova OM, Stoppa-Lyonnet D, Lenoir GM, Mazoyer S.

Hum Mol Genet. 2002 Nov 1;11(23):2805-14.PMID: 12393792 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.

Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M.

Diabetes. 2003 Dec;52(12):2989-95.PMID: 14633861 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

Frayling TM, Evans JC, Bulman MP, Pearson E, Allen L, Owen K, Bingham C, Hannemann M, Shepherd M, Ellard S, Hattersley AT.

Diabetes. 2001 Feb;50 Suppl 1:S94-100.PMID: 11272211 [PubMed - indexed for MEDLINE]Related articles

Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.

Ng MC, Cockburn BN, Lindner TH, Yeung VT, Chow CC, So WY, Li JK, Lo YM, Lee ZS, Cockram CS, Critchley JA, Bell GI, Chan JC.

Diabet Med. 1999 Nov;16(11):956-63.PMID: 10588527 [PubMed - indexed for MEDLINE]Related articles

Identification and functional analysis of mutations in the hepatocyte nuclear factor-1alpha gene in anti-islet autoantibody-negative Japanese patients with type 1 diabetes.

Kawasaki E, Sera Y, Yamakawa K, Abe T, Ozaki M, Uotani S, Ohtsu N, Takino H, Yamasaki H, Yamaguchi Y, Matsuura N, Eguchi K.

J Clin Endocrinol Metab. 2000 Jan;85(1):331-5.PMID: 10634407 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a new mutation in the hepatocyte nuclear factor-1alpha gene in a Polish family with early-onset type 2 diabetes mellitus.

Malecki MT, Klupa T, Frey J, Cyganek K, Galicka-Stankowska D, Wanic K, Sieradzki J.

Diabetes Nutr Metab. 2001 Oct;14(5):288-91.PMID: 11806470 [PubMed - indexed for MEDLINE]Related articles

Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene.

Gragnoli C, Lindner T, Cockburn BN, Kaisaki PJ, Gragnoli F, Marozzi G, Bell GI.

Diabetes. 1997 Oct;46(10):1648-51.PMID: 9313764 [PubMed - indexed for MEDLINE]Related articles

Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients.

Godart F, Bellanné-Chantelot C, Clauin S, Gragnoli C, Abderrahmani A, Blanché H, Boutin P, Chèvre JC, Froguel P, Bailleul B.

Hum Mutat. 2000;15(2):173-80.PMID: 10649494 [PubMed - indexed for MEDLINE]Related articles

MODY associated with two novel hepatocyte nuclear factor-1alpha loss-of-function mutations (P112L and Q466X).

Bjørkhaug L, Ye H, Horikawa Y, Søvik O, Molven A, Njølstad PR.

Biochem Biophys Res Commun. 2000 Dec 29;279(3):792-8.PMID: 11162430 [PubMed - indexed for MEDLINE]Related articles

Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.

Okita K, Yang Q, Yamagata K, Hangenfeldt KA, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim CB, Hanafusa T, Matsuzawa Y.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):566-9.PMID: 10491332 [PubMed - indexed for MEDLINE]Related articles

A rapid screening method for hepatocyte nuclear factor 1 alpha frameshift mutations; prevalence in maturity-onset diabetes of the young and late-onset non-insulin dependent diabetes.

Frayling TM, Bulman MP, Appleton M, Hattersley AT, Ellard S.

Hum Genet. 1997 Dec;101(3):351-4.PMID: 9439666 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway.

Bjørkhaug L, Sagen JV, Thorsby P, Søvik O, Molven A, Njølstad PR.

J Clin Endocrinol Metab. 2003 Feb;88(2):920-31.PMID: 12574234 [PubMed - indexed for MEDLINE]Related articlesFree article