PubMed

Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.

Muzumdar R, Ma X, Atzmon G, Vuguin P, Yang X, Barzilai N.

Diabetes. 2004 Feb;53(2):441-6.PMID: 14747296 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats.

Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF, Giacca A.

Diabetes. 1999 Mar;48(3):524-30.PMID: 10078552 [PubMed - indexed for MEDLINE]Related articlesFree article

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.

Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K.

Diabetes. 2003 Oct;52(10):2461-74.PMID: 14514628 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes.

Carpentier A, Zinman B, Leung N, Giacca A, Hanley AJ, Harris SB, Hegele RA, Lewis GF.

Diabetes. 2003 Jun;52(6):1485-95.PMID: 12765961 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin.

Meneilly GS, Ryan AS, Minaker KL, Elahi D.

J Clin Endocrinol Metab. 1998 Aug;83(8):2925-32.PMID: 9709971 [PubMed - indexed for MEDLINE]Related articlesFree article

High-fat- and lipid-induced insulin resistance in rats: the comparison of glucose metabolism, plasma resistin and adiponectin levels.

Li L, Yang G, Li Q, Tang Y, Li K.

Ann Nutr Metab. 2006;50(6):499-505. Epub 2006 Dec 21.PMID: 17191023 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats.

Dobbins RL, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, Giacca A, McGarry JD.

Diabetes. 2002 Jun;51(6):1825-33.PMID: 12031970 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF.

Diabetes. 2000 Mar;49(3):399-408.PMID: 10868961 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of a 48-h fat infusion on insulin secretion and glucose utilization.

Boden G, Chen X, Rosner J, Barton M.

Diabetes. 1995 Oct;44(10):1239-42.PMID: 7556964 [PubMed - indexed for MEDLINE]Related articles

Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.

Cusi K, Kashyap S, Gastaldelli A, Bajaj M, Cersosimo E.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1775-81. Epub 2007 Feb 13.PMID: 17299078 [PubMed - indexed for MEDLINE]Related articlesFree article

[Morphological and functional characteristics of pancreatic islet beta cells in natural aging SD rats]

Wang S, Li J, Li XJ.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Mar;39(2):197-201. Chinese. PMID: 18630682 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes.

Storgaard H, Jensen CB, Vaag AA, Vølund A, Madsbad S.

Metabolism. 2003 Jul;52(7):885-94.PMID: 12870166 [PubMed - indexed for MEDLINE]Related articles

Lack of effect of a physiological elevation of plasma non-esterified fatty acid levels on insulin secretion.

Frias JP, Basabe L, Macaraeg G, Kruszynska YT.

Diabetes Metab. 2000 Apr;26(2):133-9.PMID: 10804328 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation.

Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF.

Am J Physiol. 1999 Jun;276(6 Pt 1):E1055-66.PMID: 10362618 [PubMed - indexed for MEDLINE]Related articlesFree article

A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.

Zhou YP, Berggren PO, Grill V.

Diabetes. 1996 May;45(5):580-6.PMID: 8621007 [PubMed - indexed for MEDLINE]Related articles

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E549-60. Epub 2006 Sep 26.PMID: 17003242 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes.

Boden G, Chen X.

Diabetes. 1999 Mar;48(3):577-83.PMID: 10078559 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.

Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT.

Diabetes. 1998 Oct;47(10):1613-8.PMID: 9753300 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of free fatty acids on plasma resistin and insulin resistance in awake rats.

Yang G, Li L, Fang C, Zhang L, Li Q, Tang Y, Boden G.

Metabolism. 2005 Sep;54(9):1142-6.PMID: 16125524 [PubMed - indexed for MEDLINE]Related articles