PubMed

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT.

Diabetes. 2004 Feb;53(2):410-7.PMID: 14747292 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice.

Liang Y, Osborne MC, Monia BP, Bhanot S, Watts LM, She P, DeCarlo SO, Chen X, Demarest K.

Metabolism. 2005 Jul;54(7):848-55.PMID: 15988691 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 receptor agonist ZP10A increases insulin mRNA expression and prevents diabetic progression in db/db mice.

Thorkildsen C, Neve S, Larsen BD, Meier E, Petersen JS.

J Pharmacol Exp Ther. 2003 Nov;307(2):490-6. Epub 2003 Sep 15.PMID: 12975499 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.

Watts LM, Manchem VP, Leedom TA, Rivard AL, McKay RA, Bao D, Neroladakis T, Monia BP, Bodenmiller DM, Cao JX, Zhang HY, Cox AL, Jacobs SJ, Michael MD, Sloop KW, Bhanot S.

Diabetes. 2005 Jun;54(6):1846-53.PMID: 15919808 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.

Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC.

Endocrinology. 2006 Nov;147(11):5061-8. Epub 2006 Jul 27.PMID: 16873540 [PubMed - indexed for MEDLINE]Related articlesFree article

Somatostatin receptor subtype-2-deficient mice with diet-induced obesity have hyperglycemia, nonfasting hyperglucagonemia, and decreased hepatic glycogen deposition.

Singh V, Grötzinger C, Nowak KW, Zacharias S, Göncz E, Pless G, Sauer IM, Eichhorn I, Pfeiffer-Guglielmi B, Hamprecht B, Wiedenmann B, Plöckinger U, Strowski MZ.

Endocrinology. 2007 Aug;148(8):3887-99. Epub 2007 May 24.PMID: 17525126 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.

Sloop KW, Cao JX, Siesky AM, Zhang HY, Bodenmiller DM, Cox AL, Jacobs SJ, Moyers JS, Owens RA, Showalter AD, Brenner MB, Raap A, Gromada J, Berridge BR, Monteith DK, Porksen N, McKay RA, Monia BP, Bhanot S, Watts LM, Michael MD.

J Clin Invest. 2004 Jun;113(11):1571-81.PMID: 15173883 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus.

Opherk C, Tronche F, Kellendonk C, Kohlmüller D, Schulze A, Schmid W, Schütz G.

Mol Endocrinol. 2004 Jun;18(6):1346-53. Epub 2004 Mar 18.PMID: 15031319 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.

Yu XX, Murray SF, Pandey SK, Booten SL, Bao D, Song XZ, Kelly S, Chen S, McKay R, Monia BP, Bhanot S.

Hepatology. 2005 Aug;42(2):362-71.PMID: 16001399 [PubMed - indexed for MEDLINE]Related articles

Regulation of glucagon receptor mRNA in cultured primary rat hepatocytes by glucose and cAMP.

Abrahamsen N, Lundgren K, Nishimura E.

J Biol Chem. 1995 Jun 30;270(26):15853-7.PMID: 7541048 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression.

Yu XX, Pandey SK, Booten SL, Murray SF, Monia BP, Bhanot S.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E530-9. Epub 2008 Jan 15.PMID: 18198353 [PubMed - indexed for MEDLINE]Related articlesFree article

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.

Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1438-43. Epub 2003 Jan 24.PMID: 12552113 [PubMed - indexed for MEDLINE]Related articlesFree article

The possible role of age-related increase in the plasma glucagon/insulin ratio in the enhanced hepatic gluconeogenesis and hyperglycemia in genetically diabetic (C57BL/KsJ-db/db) mice.

Kodama H, Fujita M, Yamazaki M, Yamaguchi I.

Jpn J Pharmacol. 1994 Nov;66(3):281-7.PMID: 7869614 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice.

Fujiwara T, Wada M, Fukuda K, Fukami M, Yoshioka S, Yoshioka T, Horikoshi H.

Metabolism. 1991 Nov;40(11):1213-8.PMID: 1943750 [PubMed - indexed for MEDLINE]Related articles

Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors.

Li X, Hansen PA, Xi L, Chandraratna RA, Burant CF.

J Biol Chem. 2005 Nov 18;280(46):38317-27. Epub 2005 Sep 22.PMID: 16179348 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo and in vitro regulation of hepatic glucagon receptor mRNA concentration by glucose metabolism.

Burcelin R, Mrejen C, Decaux JF, De Mouzon SH, Girard J, Charron MJ.

J Biol Chem. 1998 Apr 3;273(14):8088-93.PMID: 9525910 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glucagon secretion.

Young A.

Adv Pharmacol. 2005;52:151-71. Review.PMID: 16492545 [PubMed - indexed for MEDLINE]Related articles

Epigallocatechin gallate supplementation alleviates diabetes in rodents.

Wolfram S, Raederstorff D, Preller M, Wang Y, Teixeira SR, Riegger C, Weber P.

J Nutr. 2006 Oct;136(10):2512-8.PMID: 16988119 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia.

Garris DR, Garris BL.

Cell Tissue Res. 2005 Feb;319(2):231-42. Epub 2004 Nov 20.PMID: 15654653 [PubMed - indexed for MEDLINE]Related articles

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM.

Diabetes. 2006 Jul;55(7):2042-50.PMID: 16804074 [PubMed - indexed for MEDLINE]Related articlesFree article