PubMed

Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity.

Nikolic B, Takeuchi Y, Leykin I, Fudaba Y, Smith RN, Sykes M.

Diabetes. 2004 Feb;53(2):376-83.PMID: 14747288 [PubMed - indexed for MEDLINE]Related articlesFree article

A substantial level of donor hematopoietic chimerism is required to protect donor-specific islet grafts in diabetic NOD mice.

Guo Z, Wu T, Sozen H, Pan Y, Heuss N, Kalscheuer H, Sutherland DE, Blazar BR, Hering BJ.

Transplantation. 2003 Apr 15;75(7):909-15.PMID: 12698073 [PubMed - indexed for MEDLINE]Related articles

Inducing tolerance to MHC-matched allogeneic islet grafts in diabetic NOD mice by simultaneous islet and bone marrow transplantation under nonirradiative and nonmyeloablative conditioning therapy.

Wu T, Levay-Young B, Heuss N, Sozen H, Kirchhof N, Sutherland DE, Hering B, Guo Z.

Transplantation. 2002 Jul 15;74(1):22-7.PMID: 12134094 [PubMed - indexed for MEDLINE]Related articles

Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice.

Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL.

Blood. 2000 Mar 15;95(6):2175-82.PMID: 10706892 [PubMed - indexed for MEDLINE]Related articlesFree article

Robust tolerance to fully allogeneic islet transplants achieved by chimerism with minimal conditioning.

Luo B, Nanji SA, Schur CD, Pawlick RL, Anderson CC, Shapiro AM.

Transplantation. 2005 Aug 15;80(3):370-7.PMID: 16082333 [PubMed - indexed for MEDLINE]Related articles

Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice.

Li H, Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST.

J Immunol. 1996 Jan 1;156(1):380-8.PMID: 8598488 [PubMed - indexed for MEDLINE]Related articles

Prevention of diabetes in nonobese diabetic mice by nonmyeloablative allogeneic bone marrow transplantation.

Elkin G, Prigozhina TB, Slavin S.

Exp Hematol. 2004 Jun;32(6):579-84.PMID: 15183899 [PubMed - indexed for MEDLINE]Related articles

Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice.

Zhang C, Todorov I, Lin CL, Atkinson M, Kandeel F, Forman S, Zeng D.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2337-42. Epub 2007 Jan 31.PMID: 17267595 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras.

Chan WF, Razavy H, Luo B, Shapiro AM, Anderson CC.

J Immunol. 2008 Apr 15;180(8):5177-86.PMID: 18390699 [PubMed - indexed for MEDLINE]Related articlesFree article

Progress toward production of immunologic tolerance with no or minimal toxic immunosuppression for prevention of immunodeficiency and autoimmune diseases.

Good RA.

World J Surg. 2000 Jul;24(7):797-810. Review.PMID: 10833246 [PubMed - indexed for MEDLINE]Related articles

Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning.

Kim YM, Mapara MY, Down JD, Johnson KW, Boisgerault F, Akiyama Y, Benichou G, Pelot M, Zhao G, Sykes M.

Blood. 2004 Jan 15;103(2):732-9. Epub 2003 Sep 25.PMID: 14512313 [PubMed - indexed for MEDLINE]Related articlesFree article

Donor CD8+ T cells facilitate induction of chimerism and tolerance without GVHD in autoimmune NOD mice conditioned with anti-CD3 mAb.

Liang Y, Huang T, Zhang C, Todorov I, Atkinson M, Kandeel F, Forman S, Zeng D.

Blood. 2005 Mar 1;105(5):2180-8. Epub 2004 Sep 16.PMID: 15374883 [PubMed - indexed for MEDLINE]Related articlesFree article

Allogeneic chimerism induces donor-specific tolerance to simultaneous islet allografts in nonobese diabetic mice.

Li H, Kaufman CL, Ildstad ST.

Surgery. 1995 Aug;118(2):192-7; discussion 197-8.PMID: 7638733 [PubMed - indexed for MEDLINE]Related articles

A more persistent tolerance to islet allografts through bone marrow transplantation in minimal nonmyeloablative conditioning therapy.

Lee BW, Lee JI, Oh SH, Ahn YR, Chae HY, Lee MS, Lee MK, Kim KW.

Transplant Proc. 2005 Jun;37(5):2266-9.PMID: 15964395 [PubMed - indexed for MEDLINE]Related articles

Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice.

Verda L, Kim DA, Ikehara S, Statkute L, Bronesky D, Petrenko Y, Oyama Y, He X, Link C, Vahanian NN, Burt RK.

Stem Cells. 2008 Feb;26(2):381-6. Epub 2007 Nov 1.PMID: 17975228 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen.

Manilay JO, Pearson DA, Sergio JJ, Swenson KG, Sykes M.

Transplantation. 1998 Jul 15;66(1):96-102.PMID: 9679828 [PubMed - indexed for MEDLINE]Related articles

Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation.

Li JM, Gorechlad J, Larsen CP, Waller EK.

Biol Blood Marrow Transplant. 2006 Dec;12(12):1239-49.PMID: 17162205 [PubMed - indexed for MEDLINE]Related articles

Patterns of hemopoietic reconstitution in nonobese diabetic mice: dichotomy of allogeneic resistance versus competitive advantage of disease-resistant marrow.

Kaufman CL, Li H, Ildstad ST.

J Immunol. 1997 Mar 1;158(5):2435-42.PMID: 9036994 [PubMed - indexed for MEDLINE]Related articles

Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice.

Beilhack GF, Scheffold YC, Weissman IL, Taylor C, Jerabek L, Burge MJ, Masek MA, Shizuru JA.

Diabetes. 2003 Jan;52(1):59-68.PMID: 12502494 [PubMed - indexed for MEDLINE]Related articlesFree article

A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation.

Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR.

Blood. 2002 Mar 1;99(5):1840-9.PMID: 11861303 [PubMed - indexed for MEDLINE]Related articlesFree article