PubMed

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.

Diabetes. 2004 Jan;53(1):141-8.PMID: 14693708 [PubMed - indexed for MEDLINE]Related articlesFree article

The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

Wang J, Xu J, Finnerty J, Furuta M, Steiner DF, Verchere CB.

Diabetes. 2001 Mar;50(3):534-9.PMID: 11246872 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.

Marzban L, Soukhatcheva G, Verchere CB.

Endocrinology. 2005 Apr;146(4):1808-17. Epub 2004 Dec 23.PMID: 15618358 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation.

Paulsson JF, Westermark GT.

Diabetes. 2005 Jul;54(7):2117-25.PMID: 15983213 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells.

Marzban L, Trigo-Gonzalez G, Verchere CB.

Mol Endocrinol. 2005 Aug;19(8):2154-63. Epub 2005 Mar 31.PMID: 15802374 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.

Higham CE, Hull RL, Lawrie L, Shennan KI, Morris JF, Birch NP, Docherty K, Clark A.

Eur J Biochem. 2000 Aug;267(16):4998-5004.PMID: 10931181 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2.

Badman MK, Shennan KI, Jermany JL, Docherty K, Clark A.

FEBS Lett. 1996 Jan 15;378(3):227-31.PMID: 8557106 [PubMed - indexed for MEDLINE]Related articles

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.

Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ.

J Biol Chem. 2006 Apr 21;281(16):11050-7. Epub 2006 Feb 13.PMID: 16476726 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.

Paulsson JF, Andersson A, Westermark P, Westermark GT.

Diabetologia. 2006 Jun;49(6):1237-46. Epub 2006 Mar 29.PMID: 16570161 [PubMed - indexed for MEDLINE]Related articles

Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.

Benjannet S, Rondeau N, Paquet L, Boudreault A, Lazure C, Chrétien M, Seidah NG.

Biochem J. 1993 Sep 15;294 ( Pt 3):735-43.PMID: 8397508 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.

Brakch N, Rist B, Beck-Sickinger AG, Goenaga J, Wittek R, Bürger E, Brunner HR, Grouzmann E.

Biochemistry. 1997 Dec 23;36(51):16309-20.PMID: 9405066 [PubMed - indexed for MEDLINE]Related articles

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.

Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ.

Diabetes. 2007 Nov;56(11):2744-52. Epub 2007 Aug 13.PMID: 17698597 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.

Marcinkiewicz M, Ramla D, Seidah NG, Chrétien M.

Endocrinology. 1994 Oct;135(4):1651-60.PMID: 7925129 [PubMed - indexed for MEDLINE]Related articles

Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells.

Neerman-Arbez M, Cirulli V, Halban PA.

Biochem J. 1994 May 15;300 ( Pt 1):57-61.PMID: 8198551 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: implications for amyloid formation.

Abedini A, Tracz SM, Cho JH, Raleigh DP.

Biochemistry. 2006 Aug 1;45(30):9228-37.PMID: 16866369 [PubMed - indexed for MEDLINE]Related articles

Proglucagon processing in an islet cell line: effects of PC1 overexpression and PC2 depletion.

Dhanvantari S, Brubaker PL.

Endocrinology. 1998 Apr;139(4):1630-7.PMID: 9528943 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the thyrotropin-releasing hormone precursor, its processing products, and its coexpression with convertase 1 in primary cultures of hypothalamic neurons: anatomic distribution of PC1 and PC2.

Nillni EA, Luo LG, Jackson IM, McMillan P.

Endocrinology. 1996 Dec;137(12):5651-61.PMID: 8940396 [PubMed - indexed for MEDLINE]Related articles

Prohormone convertases (PC1/3 and PC2) in rat and human pancreas and islet cell tumors: subcellular immunohistochemical analysis.

Itoh Y, Tanaka S, Takekoshi S, Itoh J, Osamura RY.

Pathol Int. 1996 Oct;46(10):726-37.PMID: 8916141 [PubMed - indexed for MEDLINE]Related articles

Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3.

Dey A, Xhu X, Carroll R, Turck CW, Stein J, Steiner DF.

J Biol Chem. 2003 Apr 25;278(17):15007-14. Epub 2003 Feb 12.PMID: 12584191 [PubMed - indexed for MEDLINE]Related articlesFree article