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    Results: 1 to 20 of 106

    1.

    Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

    Wang X, Li H, De Leo D, Guo W, Koshkin V, Fantus IG, Giacca A, Chan CB, Der S, Wheeler MB.

    Diabetes. 2004 Jan;53(1):129-40.PMID: 14693707 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids.

    Bikopoulos G, da Silva Pimenta A, Lee SC, Lakey JR, Der SD, Chan CB, Ceddia RB, Wheeler MB, Rozakis-Adcock M.

    J Endocrinol. 2008 Mar;196(3):455-64.PMID: 18310441 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells.

    Wang O, Cai K, Pang S, Wang T, Qi D, Zhu Q, Ni Z, Le Y.

    Endocrinology. 2008 Feb;149(2):672-80. Epub 2007 Oct 25.PMID: 17962352 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

    Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

    J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases.

    Hou N, Torii S, Saito N, Hosaka M, Takeuchi T.

    Endocrinology. 2008 Apr;149(4):1654-65. Epub 2008 Jan 10.PMID: 18187551 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo.

    Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.

    Diabetes. 2006 Jun;55(6):1614-24.PMID: 16731823 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways.

    Takahashi H, Tran PO, LeRoy E, Harmon JS, Tanaka Y, Robertson RP.

    J Biol Chem. 2004 Sep 3;279(36):37316-23. Epub 2004 Jun 22.PMID: 15213233 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function.

    Busch AK, Cordery D, Denyer GS, Biden TJ.

    Diabetes. 2002 Apr;51(4):977-87.PMID: 11916915 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response.

    Soto A, DelRaso NJ, Schlager JJ, Chan VT.

    Toxicology. 2008 Jan 14;243(1-2):177-92. Epub 2007 Oct 23.PMID: 18061331 [PubMed - indexed for MEDLINE]Related articles

    10.

    Mechanisms associated with loss of glucose responsiveness in beta cells.

    O'Driscoll L, Gammell P, Clynes M.

    Transplant Proc. 2004 May;36(4):1159-62.PMID: 15194402 [PubMed - indexed for MEDLINE]Related articles

    11.

    Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade.

    Chen JR, Shankar K, Nagarajan S, Badger TM, Ronis MJ.

    J Pharmacol Exp Ther. 2008 Jan;324(1):50-9. Epub 2007 Oct 4.PMID: 17916759 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.

    Weber DS, Taniyama Y, Rocic P, Seshiah PN, Dechert MA, Gerthoffer WT, Griendling KK.

    Circ Res. 2004 May 14;94(9):1219-26. Epub 2004 Apr 1.PMID: 15059930 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells.

    Tsubouchi H, Inoguchi T, Inuo M, Kakimoto M, Sonta T, Sonoda N, Sasaki S, Kobayashi K, Sumimoto H, Nawata H.

    Biochem Biophys Res Commun. 2005 Jan 7;326(1):60-5.PMID: 15567152 [PubMed - indexed for MEDLINE]Related articles

    14.

    Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid.

    Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Head E, Sharman E, Liu J.

    J Cell Biochem. 2008 Jul 1;104(4):1232-43.PMID: 18260126 [PubMed - indexed for MEDLINE]Related articles

    15.

    Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro.

    Gustafsson AC, Kupershmidt I, Edlundh-Rose E, Greco G, Serafino A, Krasnowska EK, Lundeberg T, Bracci-Laudiero L, Romano MC, Parasassi T, Lundeberg J.

    BMC Cancer. 2005 Jul 7;5:75.PMID: 16001974 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.

    Li WQ, Qureshi HY, Liacini A, Dehnade F, Zafarullah M.

    Free Radic Biol Med. 2004 Jul 15;37(2):196-207.PMID: 15203191 [PubMed - indexed for MEDLINE]Related articles

    17.

    Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.

    Diao J, Asghar Z, Chan CB, Wheeler MB.

    J Biol Chem. 2005 Sep 30;280(39):33487-96. Epub 2005 Jul 14.PMID: 16027126 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury.

    Esposito G, Imitola J, Lu J, De Filippis D, Scuderi C, Ganesh VS, Folkerth R, Hecht J, Shin S, Iuvone T, Chesnut J, Steardo L, Sheen V.

    Hum Mol Genet. 2008 Feb 1;17(3):440-57. Epub 2007 Nov 5.PMID: 17984171 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells.

    Targonsky ED, Dai F, Koshkin V, Karaman GT, Gyulkhandanyan AV, Zhang Y, Chan CB, Wheeler MB.

    Diabetologia. 2006 Jul;49(7):1587-98. Epub 2006 May 13.PMID: 16752177 [PubMed - indexed for MEDLINE]Related articles

    20.

    Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids.

    Koshkin V, Wang X, Scherer PE, Chan CB, Wheeler MB.

    J Biol Chem. 2003 May 30;278(22):19709-15. Epub 2003 Mar 17.PMID: 12642585 [PubMed - indexed for MEDLINE]Related articlesFree article

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