PubMed

Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs.

Okitsu T, Kobayashi N, Jun HS, Shin S, Kim SJ, Han J, Kwon H, Sakaguchi M, Totsugawa T, Kohara M, Westerman KA, Tanaka N, Leboulch P, Yoon JW.

Diabetes. 2004 Jan;53(1):105-12.PMID: 14693704 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.

Zalzman M, Gupta S, Giri RK, Berkovich I, Sappal BS, Karnieli O, Zern MA, Fleischer N, Efrat S.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7253-8. Epub 2003 May 19.PMID: 12756298 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of hepatocyte-rich liver cell mixture and liver fibroblasts on prolonging graft islet survival in rats without immunosuppressive drugs.

Soto-Montenegro L, Zugasti-Murillo A, Rollán E, Alvarez Y, Alvarez G, Jara-Albarrán A.

Exp Clin Endocrinol Diabetes. 2004 Nov;112(10):580-6.PMID: 15578333 [PubMed - indexed for MEDLINE]Related articles

Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model.

Chen NK, Wong JS, Kee IH, Lai SH, Thng CH, Ng WH, Ng RT, Tan SY, Lee SY, Tan ME, Sivalingam J, Chow PK, Kon OL.

PLoS One. 2008 Mar 5;3(3):e1734.PMID: 18320053 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a porcine model of type 1 diabetes by total pancreatectomy and establishment of a glucose tolerance evaluation method.

Kobayashi K, Kobayashi N, Okitsu T, Yong C, Fukazawa T, Ikeda H, Kosaka Y, Narushima M, Arata T, Tanaka N.

Artif Organs. 2004 Nov;28(11):1035-42.PMID: 15504119 [PubMed - indexed for MEDLINE]Related articles

Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.

Kin T, Korbutt GS, Kobayashi T, Dufour JM, Rajotte RV.

Diabetes. 2005 Apr;54(4):1032-9.PMID: 15793241 [PubMed - indexed for MEDLINE]Related articlesFree article

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach.

Fodor A, Harel C, Fodor L, Armoni M, Salmon P, Trono D, Karnieli E.

Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.PMID: 17131142 [PubMed - indexed for MEDLINE]Related articles

High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells.

Cao LZ, Tang DQ, Horb ME, Li SW, Yang LJ.

Diabetes. 2004 Dec;53(12):3168-78.PMID: 15561947 [PubMed - indexed for MEDLINE]Related articlesFree article

Engineered enteroendocrine cells secrete insulin in response to glucose and reverse hyperglycemia in diabetic mice.

Han J, Lee HH, Kwon H, Shin S, Yoon JW, Jun HS.

Mol Ther. 2007 Jun;15(6):1195-202. Epub 2007 Feb 13.PMID: 17299398 [PubMed - indexed for MEDLINE]Related articles

Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.

Totsugawa T, Yong C, Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Westerman KA, Kohara M, Reth M, Tanaka N, Leboulch P, Kobayashi N.

J Hepatol. 2007 Jul;47(1):74-82. Epub 2007 Mar 15.PMID: 17434229 [PubMed - indexed for MEDLINE]Related articles

Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration.

Kim S, Shin JS, Kim HJ, Fisher RC, Lee MJ, Kim CW.

Lab Invest. 2007 Jul;87(7):702-12. Epub 2007 May 7.PMID: 17483848 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a novel beta-cell specific promoter system for the identification of insulin-producing cells in in vitro cell cultures.

Fukazawa T, Matsuoka J, Naomoto Y, Nakai T, Durbin ML, Kojima I, Lakey JR, Tanaka N.

Exp Cell Res. 2006 Oct 15;312(17):3404-12. Epub 2006 Jul 28.PMID: 16934249 [PubMed - indexed for MEDLINE]Related articles

Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy.

Li J, Li LJ, Cao HC, Sheng GP, Yu HY, Xu W, Sheng JF.

ASAIO J. 2005 May-Jun;51(3):262-8.PMID: 15968957 [PubMed - indexed for MEDLINE]Related articles

A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice.

Casares S, Lin M, Zhang N, Teijaro JR, Stoica C, McEvoy R, Farber DL, Bona C, Brumeanu TD.

Transplantation. 2008 Jun 27;85(12):1717-25.PMID: 18580462 [PubMed - indexed for MEDLINE]Related articles

c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells.

Collier JJ, Zhang P, Pedersen KB, Burke SJ, Haycock JW, Scott DK.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E48-56. Epub 2007 Mar 6.PMID: 17341548 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of insulin secretion in engineered liver cells by nitric oxide.

Muniappan L, Ozcan S.

BMC Physiol. 2007 Oct 17;7:11.PMID: 17941991 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin.

Lee Y, Ravazzola M, Park BH, Bashmakov YK, Orci L, Unger RH.

Diabetes. 2007 Sep;56(9):2295-301. Epub 2007 Jun 11.PMID: 17563069 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell therapy for diabetes mellitus.

Kobayashi N.

Cell Transplant. 2006;15(10):849-54. Review.PMID: 17299988 [PubMed - indexed for MEDLINE]Related articles

A human beta-cell line for transplantation therapy to control type 1 diabetes.

Narushima M, Kobayashi N, Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JR, Leboulch P, Tanaka N, Yoon JW.

Nat Biotechnol. 2005 Oct;23(10):1274-82. Epub 2005 Sep 25.PMID: 16186810 [PubMed - indexed for MEDLINE]Related articles

Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats.

Choi SB, Jang JS, Hong SM, Jun DW, Park S.

J Endocrinol. 2006 Aug;190(2):471-82.PMID: 16899580 [PubMed - indexed for MEDLINE]Related articlesFree article