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Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose.

Yang XJ, Kow LM, Pfaff DW, Mobbs CV.

Diabetes. 2004 Jan;53(1):67-73.PMID: 14693699 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

Yang XJ, Kow LM, Funabashi T, Mobbs CV.

Diabetes. 1999 Sep;48(9):1763-72.PMID: 10480606 [PubMed - indexed for MEDLINE]Related articlesFree article

Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons.

Kang L, Sanders NM, Dunn-Meynell AA, Gaspers LD, Routh VH, Thomas AP, Levin BE.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R784-92. Epub 2007 Dec 19.PMID: 18094065 [PubMed - indexed for MEDLINE]Related articles

Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus.

Song Z, Routh VH.

Diabetes. 2005 Jan;54(1):15-22.PMID: 15616006 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing.

Kang L, Dunn-Meynell AA, Routh VH, Gaspers LD, Nagata Y, Nishimura T, Eiki J, Zhang BB, Levin BE.

Diabetes. 2006 Feb;55(2):412-20. Erratum in: Diabetes. 2006 Mar;55(3):862. PMID: 16443775 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses.

Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS.

Diabetes. 2004 Oct;53(10):2542-51.PMID: 15448082 [PubMed - indexed for MEDLINE]Related articlesFree article

Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus.

Song Z, Routh VH.

Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1283-7. Epub 2006 Jun 22.PMID: 16793940 [PubMed - indexed for MEDLINE]Related articles

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS.

Diabetes. 2005 Nov;54(11):3169-74.PMID: 16249441 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.

McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS.

Diabetes. 2004 Aug;53(8):1953-8.PMID: 15277372 [PubMed - indexed for MEDLINE]Related articlesFree article

Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.

Levin BE, Becker TC, Eiki J, Zhang BB, Dunn-Meynell AA.

Diabetes. 2008 May;57(5):1371-9. Epub 2008 Feb 21.PMID: 18292346 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation.

Cheng H, Isoda F, Belsham DD, Mobbs CV.

Endocrinology. 2008 Feb;149(2):703-10. Epub 2007 Nov 1.PMID: 17974626 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.

Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS.

Diabetes. 2006 Apr;55(4):1080-7.PMID: 16567532 [PubMed - indexed for MEDLINE]Related articlesFree article

Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing.

O'Malley D, Reimann F, Simpson AK, Gribble FM.

Diabetes. 2006 Dec;55(12):3381-6.PMID: 17130483 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons.

Kang L, Routh VH, Kuzhikandathil EV, Gaspers LD, Levin BE.

Diabetes. 2004 Mar;53(3):549-59.PMID: 14988237 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia.

Alquier T, Kawashima J, Tsuji Y, Kahn BB.

Endocrinology. 2007 Mar;148(3):1367-75. Epub 2006 Dec 21.PMID: 17185376 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucosensing neurons in the ventromedial hypothalamic nucleus (VMN) and hypoglycemia-associated autonomic failure (HAAF).

Routh VH.

Diabetes Metab Res Rev. 2003 Sep-Oct;19(5):348-56. Review.PMID: 12951642 [PubMed - indexed for MEDLINE]Related articles

Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus.

Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH.

Diabetes. 2001 Dec;50(12):2673-81.PMID: 11723049 [PubMed - indexed for MEDLINE]Related articlesFree article

CCK-8 stimulation of ventromedial hypothalamic neurons in vitro: a feeding-relevant event?

Kow LM, Pfaff DW.

Peptides. 1986 May-Jun;7(3):473-9.PMID: 3774589 [PubMed - indexed for MEDLINE]Related articles

[Effect of glucose on the polysensory properties of neurons of the ventromedial nucleus of the hypothalamus]

Smirnov SI, Pluzhnichenko EB.

Fiziol Zh SSSR Im I M Sechenova. 1988 Mar;74(3):318-25. Russian. PMID: 3384125 [PubMed - indexed for MEDLINE]Related articles

Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation.

McCrimmon RJ, Fan X, Cheng H, McNay E, Chan O, Shaw M, Ding Y, Zhu W, Sherwin RS.

Diabetes. 2006 Jun;55(6):1755-60.PMID: 16731839 [PubMed - indexed for MEDLINE]Related articlesFree article