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    Results: 1 to 20 of 225

    1.

    Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.

    Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF.

    Diabetes. 2004 Jan;53(1):61-6.PMID: 14693698 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

    Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.

    J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.PMID: 17545163 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

    Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

    Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis.

    Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, Parsons R, White MF.

    J Biol Chem. 2005 Nov 25;280(47):39388-93. Epub 2005 Sep 16.PMID: 16170201 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

    Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM.

    Diabetes. 2003 Jan;52(1):21-8.PMID: 12502489 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

    Kubota N, Terauchi Y, Tobe K, Yano W, Suzuki R, Ueki K, Takamoto I, Satoh H, Maki T, Kubota T, Moroi M, Okada-Iwabu M, Ezaki O, Nagai R, Ueta Y, Kadowaki T, Noda T.

    J Clin Invest. 2004 Oct;114(7):917-27.PMID: 15467830 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Pdx1 restores beta cell function in Irs2 knockout mice.

    Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF.

    J Clin Invest. 2002 May;109(9):1193-201.PMID: 11994408 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.

    Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Rondinone CM, Valverde AM, Lorenzo M.

    Diabetes. 2007 Feb;56(2):404-13.PMID: 17259385 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.

    Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG.

    J Biol Chem. 2005 Apr 15;280(15):15038-46. Epub 2005 Feb 7.PMID: 15699041 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.

    Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF.

    J Biol Chem. 2006 Jan 13;281(2):1159-68. Epub 2005 Nov 4.PMID: 16272563 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.

    Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK.

    Diabetes. 2009 Mar;58(3):590-9. Epub 2008 Dec 15.PMID: 19074988 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

    Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF.

    Diabetes. 2002 Aug;51(8):2405-11.PMID: 12145151 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.

    Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF.

    J Neurosci. 2003 Aug 6;23(18):7084-92.PMID: 12904469 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    The role of protein tyrosine phosphatase 1B in Ras signaling.

    Dubé N, Cheng A, Tremblay ML.

    Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1834-9. Epub 2004 Feb 6.PMID: 14766979 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.

    Clampit JE, Meuth JL, Smith HT, Reilly RM, Jirousek MR, Trevillyan JM, Rondinone CM.

    Biochem Biophys Res Commun. 2003 Jan 10;300(2):261-7.PMID: 12504077 [PubMed - indexed for MEDLINE]Related articles

    16.

    PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

    Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR.

    Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11357-62. Epub 2002 Aug 8.PMID: 12169659 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

    Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ.

    J Clin Invest. 2005 Apr;115(4):940-50. Epub 2005 Mar 24.PMID: 15841180 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression.

    Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ.

    Mol Endocrinol. 2004 Jun;18(6):1333-45. Epub 2004 Feb 19.PMID: 14976221 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

    Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T.

    Mol Cell Biol. 2005 Jan;25(2):819-29.PMID: 15632081 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

    Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ.

    Diabetologia. 2007 Jun;50(6):1248-56. Epub 2007 Mar 29.PMID: 17393136 [PubMed - indexed for MEDLINE]Related articles

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