PubMed

Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.

Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T.

Diabetes. 2003 Dec;52(12):2905-13.PMID: 14633850 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.PMID: 14985368 [PubMed - indexed for MEDLINE]Related articlesFree article

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS.

J Biol Chem. 2002 Mar 15;277(11):9520-8. Epub 2002 Jan 8.PMID: 11782483 [PubMed - indexed for MEDLINE]Related articlesFree article

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.

Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A.

Oncogene. 2005 Sep 29;24(43):6465-81.PMID: 16007182 [PubMed - indexed for MEDLINE]Related articles

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.

Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N.

J Biol Chem. 1999 Dec 10;274(50):35832-9.PMID: 10585467 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

Horton JD, Shimomura I, Ikemoto S, Bashmakov Y, Hammer RE.

J Biol Chem. 2003 Sep 19;278(38):36652-60. Epub 2003 Jul 10.PMID: 12855691 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.

Repa JJ, Lund EG, Horton JD, Leitersdorf E, Russell DW, Dietschy JM, Turley SD.

J Biol Chem. 2000 Dec 15;275(50):39685-92.PMID: 11001949 [PubMed - indexed for MEDLINE]Related articlesFree article

A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.

Yahagi N, Shimano H, Hasty AH, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.

J Biol Chem. 1999 Dec 10;274(50):35840-4.PMID: 10585468 [PubMed - indexed for MEDLINE]Related articlesFree article

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL.

J Clin Invest. 1997 Mar 1;99(5):846-54.PMID: 9062341 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice.

Bécard D, Hainault I, Azzout-Marniche D, Bertry-Coussot L, Ferré P, Foufelle F.

Diabetes. 2001 Nov;50(11):2425-30.PMID: 11679417 [PubMed - indexed for MEDLINE]Related articlesFree article

Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs.

Kim HJ, Takahashi M, Ezaki O.

J Biol Chem. 1999 Sep 3;274(36):25892-8.PMID: 10464332 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance.

Ng DS, Xie C, Maguire GF, Zhu X, Ugwu F, Lam E, Connelly PW.

J Biol Chem. 2004 Feb 27;279(9):7636-42. Epub 2003 Dec 10.PMID: 14668345 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver.

Améen C, Lindén D, Larsson BM, Mode A, Holmäng A, Oscarsson J.

Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1039-48. Epub 2004 Jul 27.PMID: 15280151 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression.

Shimizu S, Ugi S, Maegawa H, Egawa K, Nishio Y, Yoshizaki T, Shi K, Nagai Y, Morino K, Nemoto K, Nakamura T, Bryer-Ash M, Kashiwagi A.

J Biol Chem. 2003 Oct 31;278(44):43095-101. Epub 2003 Aug 26.PMID: 12941932 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya-Kudo M, Hasty AH, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Takahashi A, Yato S, Sone H, Ishibashi S, Yamada N.

J Lipid Res. 2002 Jun;43(6):911-20.PMID: 12032166 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms.

Miyazaki M, Dobrzyn A, Man WC, Chu K, Sampath H, Kim HJ, Ntambi JM.

J Biol Chem. 2004 Jun 11;279(24):25164-71. Epub 2004 Apr 5.PMID: 15066988 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.

Matsumoto M, Ogawa W, Teshigawara K, Inoue H, Miyake K, Sakaue H, Kasuga M.

Diabetes. 2002 Jun;51(6):1672-80.PMID: 12031952 [PubMed - indexed for MEDLINE]Related articlesFree article

Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP).

You M, Fischer M, Deeg MA, Crabb DW.

J Biol Chem. 2002 Aug 9;277(32):29342-7. Epub 2002 May 29.PMID: 12036955 [PubMed - indexed for MEDLINE]Related articlesFree article

Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis [corrected].

Nagata R, Nishio Y, Sekine O, Nagai Y, Maeno Y, Ugi S, Maegawa H, Kashiwagi A.

J Biol Chem. 2004 Jul 9;279(28):29031-42. Epub 2004 May 3. Erratum in: J Biol Chem. 2004 Aug 27;279(35):37210. PMID: 15123654 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.

J Biol Chem. 2002 May 31;277(22):19353-7. Epub 2002 Mar 28.PMID: 11923308 [PubMed - indexed for MEDLINE]Related articlesFree article