PubMed

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, Miyatsuka T, Watada H, Leibiger IB, Yamasaki Y, Hori M.

Diabetes. 2003 Dec;52(12):2896-904.PMID: 14633849 [PubMed - indexed for MEDLINE]Related articlesFree article

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation.

Kawamori D, Kaneto H, Nakatani Y, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y.

J Biol Chem. 2006 Jan 13;281(2):1091-8. Epub 2005 Nov 9.PMID: 16282329 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of oxidative stress in pancreatic beta-cell dysfunction.

Kajimoto Y, Kaneto H.

Ann N Y Acad Sci. 2004 Apr;1011:168-76.PMID: 15126294 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress and pancreatic beta-cell dysfunction.

Kaneto H, Kawamori D, Matsuoka TA, Kajimoto Y, Yamasaki Y.

Am J Ther. 2005 Nov-Dec;12(6):529-33. Review.PMID: 16280646 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes.

Kaneto H, Kawamori D, Nakatani Y, Gorogawa S, Matsuoka TA.

Drug News Perspect. 2004 Sep;17(7):447-53. Review.PMID: 15514704 [PubMed - indexed for MEDLINE]Related articles

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression.

Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC.

J Biol Chem. 2002 Aug 16;277(33):30010-8. Epub 2002 May 14.PMID: 12011047 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.

Elrick LJ, Docherty K.

Diabetes. 2001 Oct;50(10):2244-52.PMID: 11574405 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism.

Wang X, Zhou J, Doyle ME, Egan JM.

Endocrinology. 2001 May;142(5):1820-7.PMID: 11316746 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-1beta stimulation of c-Jun NH(2)-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction.

Major CD, Wolf BA.

Diabetes. 2001 Dec;50(12):2721-8.PMID: 11723054 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.

Rafiq I, da Silva Xavier G, Hooper S, Rutter GA.

J Biol Chem. 2000 May 26;275(21):15977-84.PMID: 10821851 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.

Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W.

J Biol Chem. 2005 Apr 15;280(15):15061-70. Epub 2005 Feb 8.PMID: 15701637 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells.

Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K.

J Biol Chem. 1999 Jan 8;274(2):1011-6.PMID: 9873045 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.

Engel K, Kotlyarov A, Gaestel M.

EMBO J. 1998 Jun 15;17(12):3363-71.PMID: 9628873 [PubMed - indexed for MEDLINE]Related articlesFree article

Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress.

Seternes OM, Johansen B, Hegge B, Johannessen M, Keyse SM, Moens U.

Mol Cell Biol. 2002 Oct;22(20):6931-45.PMID: 12242275 [PubMed - indexed for MEDLINE]Related articlesFree article

Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6).

Guillemain G, Da Silva Xavier G, Rafiq I, Leturque A, Rutter GA.

Biochem J. 2004 Feb 15;378(Pt 1):219-27.PMID: 14632628 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1.

Kudo N, Taoka H, Toda T, Yoshida M, Horinouchi S.

J Biol Chem. 1999 May 21;274(21):15151-8.PMID: 10329722 [PubMed - indexed for MEDLINE]Related articlesFree article

Silymarin protects pancreatic beta-cells against cytokine-mediated toxicity: implication of c-Jun NH2-terminal kinase and janus kinase/signal transducer and activator of transcription pathways.

Matsuda T, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y.

Endocrinology. 2005 Jan;146(1):175-85. Epub 2004 Sep 30.PMID: 15459112 [PubMed - indexed for MEDLINE]Related articlesFree article

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.

Velichkova M, Hasson T.

Mol Cell Biol. 2005 Jun;25(11):4501-13.PMID: 15899855 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1.

Moede T, Leibiger B, Pour HG, Berggren P, Leibiger IB.

FEBS Lett. 1999 Nov 19;461(3):229-34.PMID: 10567702 [PubMed - indexed for MEDLINE]Related articles

Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic beta-cells.

Numazawa S, Sakaguchi H, Aoki R, Taira T, Yoshida T.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C468-74. Epub 2008 Jun 4.PMID: 18524943 [PubMed - indexed for MEDLINE]Related articlesFree article