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    Results: 1 to 20 of 284

    1.

    Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.

    Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Ørntoft T, Eizirik DL.

    Diabetes. 2003 Nov;52(11):2701-19.PMID: 14578289 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays.

    Cardozo AK, Kruhøffer M, Leeman R, Orntoft T, Eizirik DL.

    Diabetes. 2001 May;50(5):909-20.PMID: 11334433 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

    Pavlovic D, Chen MC, Gysemans CA, Mathieu C, Eizirik DL.

    Eur Cytokine Netw. 1999 Sep;10(3):403-12.PMID: 10477397 [PubMed - indexed for MEDLINE]Related articles

    4.

    STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.

    Jensen J, Galsgaard ED, Karlsen AE, Lee YC, Nielsen JH.

    J Endocrinol. 2005 Oct;187(1):25-36.PMID: 16214938 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

    Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL.

    Mol Endocrinol. 2006 Aug;20(8):1867-79. Epub 2006 Mar 23.PMID: 16556731 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis.

    Cunningham GA, McClenaghan NH, Flatt PR, Newsholme P.

    Clin Sci (Lond). 2005 Nov;109(5):447-55.PMID: 16045439 [PubMed - indexed for MEDLINE]Related articles

    7.

    Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

    Liu D, Pavlovic D, Chen MC, Flodström M, Sandler S, Eizirik DL.

    Diabetes. 2000 Jul;49(7):1116-22.PMID: 10909967 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

    Liu D, Darville M, Eizirik DL.

    Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Effect of proinflammatory cytokines on gene expression of the diabetes-associated autoantigen IA-2 in INS-1 cells.

    Steinbrenner H, Nguyen TB, Wohlrab U, Scherbaum WA, Seissler J.

    Endocrinology. 2002 Oct;143(10):3839-45.PMID: 12239095 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

    Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.

    Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.PMID: 11593036 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells.

    Naamane N, van Helden J, Eizirik DL.

    BMC Bioinformatics. 2007 Feb 15;8:55.PMID: 17302974 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Interferon regulatory factor-1 down-regulates cytokine-induced IP-10 expression in pancreatic islets.

    Baker MS, Chen X, Rotramel AR, Nelson JJ, Kaufman DB.

    Surgery. 2003 Aug;134(2):134-41.PMID: 12947309 [PubMed - indexed for MEDLINE]Related articles

    13.

    Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

    Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL.

    Diabetologia. 2001 Mar;44(3):325-32.PMID: 11317664 [PubMed - indexed for MEDLINE]Related articles

    14.

    The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells.

    Eizirik DL, Flodström M, Karlsen AE, Welsh N.

    Diabetologia. 1996 Aug;39(8):875-90. Review.PMID: 8858209 [PubMed - indexed for MEDLINE]Related articles

    15.

    Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

    Liu D, Cardozo AK, Darville MI, Eizirik DL.

    Endocrinology. 2002 Apr;143(4):1225-34.PMID: 11897677 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells.

    Han X, Sun Y, Scott S, Bleich D.

    Diabetes. 2001 May;50(5):1047-55.PMID: 11334407 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

    Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

    Diabetologia. 2008 Jul;51(7):1213-25. Epub 2008 May 8.PMID: 18463842 [PubMed - indexed for MEDLINE]Related articles

    18.

    Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction.

    Kato Y, Miura Y, Yamamoto N, Ozaki N, Oiso Y.

    Diabetologia. 2003 Sep;46(9):1228-33. Epub 2003 Jul 24.PMID: 12898012 [PubMed - indexed for MEDLINE]Related articles

    19.

    Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

    Størling J, Binzer J, Andersson AK, Züllig RA, Tonnesen M, Lehmann R, Spinas GA, Sandler S, Billestrup N, Mandrup-Poulsen T.

    Diabetologia. 2005 Oct;48(10):2039-50. Epub 2005 Aug 25.PMID: 16132952 [PubMed - indexed for MEDLINE]Related articles

    20.

    A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells.

    Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhøffer M, Ørntoft T, Eizirik DL.

    J Biol Chem. 2001 Dec 28;276(52):48879-86. Epub 2001 Oct 30.PMID: 11687580 [PubMed - indexed for MEDLINE]Related articlesFree article

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